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35 Cards in this Set

  • Front
  • Back
stimuli of nauseea and vomiting
radiation
motion
opiates
surgery
mechanism of N/V
stimulation of stretch senseitive or chemosensitive afferents, vagal afferents
direct stimulation of area postrema
vestibular afferents
action of 5-ht receptors
motion sickness drugs
dimenhydrinate (dramamine)
hydroxyzine
scopolamine
dimenhydrinate
motion sickness
mixed histamine H1/muscarinic receptor antagonist
hydroxyzine
motions sickness
mixed H1/musc receptor ant
scopolamine
motion sickness
muscarinic antagonist
MOA of motion sickness drugs
muscarinic antagonists or mixed H1/musc antagonist
ondansetron
selective 5HT-3 antagonist
vagal afferents, nst, area postrema
metoclopromide
anti-emetic
high doses has extrapyramidal side effects
antiemetic drug that has extrapyramidal side effects at high doses
metoclopramide
chlorpromazine
perchlorperazine
DA receptor blocking activity
may induce ExPy SE
dexamethasone
glucocorticoid
enhances effectiveness of other antiemetics
used to enhance effects of other antiemetics
dexamethasone
lorazepam
BDZ adjuct for cancer chemo
reduces stress and anticipatory emesis
rapid effects of chlorpromazine
chemical straightjacket )acute psychotic symptoms)
sedation, disinterest, psychomotor slowing, emotional quieting
delayed effects of chlorpromazine
2-3 weeks to develop, anti-schizophrenic effects
tension, hyperactivity, combativeness, hotility, hallucinations, delusions, insomnia, anorexia, negativism, withdrawal
early side effects of chlorpromazine
extrapyramidal symptoms (reversible and treatable,
parkinison like symptoms
akathisia
acute dystonic reactions
late onset effects of chlorpromazine
tardive dyskinesia
irreversible, untreatable
mechanism of action of chlorpromazine
D2 receptor antagonist
site of action of chlorpromaizine for schizophrenia
frontal cortex and limbic structures
site of actiono f chlorpromazine for extrapyramidal side effects
striatum
low potency antipsychotic
chlorpromazine
thioridizine
haloperidol
high potency antipsychotic
no sedation or postural hypotension
strong extrapyramidal SE
no anticholinergic effects
high potency antipsychotic
haloperidol
fluphenazin
intermediate potency antipsychotic
trifluoperazin
perphenazin
thiothixene
thioridazine
low potency antipsychotic
high sedation
high postural hypotension
high anticholinergic effects
low extrapyramidal side effects
side effects of chlorpromazine and antipsychotics
oversedation
overdose
seizures
alpha blockade
reflex tachycardia
anticholinergic (dry mouth, blurred vision, urine retention)
galactorrhea, amenorrhea
neuroleptic malignant syndrome
neuroleptic malignant syndrome
rare side effect of antypsychotics
hyperthermia, muscle rigidity, autonomic symptoms, altered consciousness
diphenhydramine
anticholinergic antiparkinson drug
used to manage extrapyramidal side effects
trihexiphenidyl
anticholinergic antiparkinson drug
manage extra pyramidal side effects of antipsychotics
benztropine
anticholinergic antiparkinson drug
manage extrapyramidal side effects of antipsychotics
drugs used to manage extrapyramidal side effects of antipsychotic drugs
diphenhydramine
trihexiphenidyl
benztropine
clozapine
second generation antipsychotic
little EPS
more effective in treating negative symptoms
side effect of clozapine
agranulocytosis
1-2%
can be fatal
second generation antipsychotics
risperidone
clozapine
olanzapine