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30 Cards in this Set
- Front
- Back
What should pregnant women be on if on anti-convulsants?
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folic acid supplement
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Where are most AEDs metabolised?
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liver
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What do Benzodiazepines do to GABA-mediated Cl- channels?
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inc frequency of opening
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What do barbiturates do to GABA-mediated Cl- channels?
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prolong opening
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What do barbiturates do to voltage-dependent sodium channels?
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blocks them
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What channel is associated iwth absence seizures?
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t-type Ca currents
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How does Gabapentin work?
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GABA reuptake inhibitor
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How does Tiagabine work?
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GABA reuptake inhibitor
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How does Phenytoin work?
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Na blocker
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How does Carbamazepine?
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Na Blocker
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How does oxcarbazepine?
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Na Blocker, K channel augmentor
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How does zonisamide work?
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Ca channels T type
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How does ethosuxamide work?
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thru Ca channel T tyoe
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How does Falbamate work?
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thru Na channels
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How does lamotrigine work?
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Na Channels, maybe glutamate, maybe Ca
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How does topiramate work?
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inc frequency of GABA, Ca, Na
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How does valproate work?
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Inc GABA, Block Na, Augment K, Maybe T type Ca
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Which drug causes erythemia multiforme?
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phenytoin
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What is Steven-Johnsons Synd?
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Erythema multiforme with muscosal involvement due to phenytoin
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What are the ADR of Carbamazepine?
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hyponaturemia and agranulocytosis
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Which drug is autostimulatory of its metabolism?
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carbamazepine
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What are the ADR of phenobarbital?
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CNS sedation, rash, tolerance, addiction
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What is primidone?
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a barbituate
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How does primidone work?
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thru prolonging GABA mediate Ca channels
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Which drug causes paradoxycal hyperexcitability in children?
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benzodiazepines
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Which drug causes a potentially life-threatening dermatitis?
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lamotrigine
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Which drugs stim CYP enzymes?
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Barbiturates, phenytoin, carbamazepine
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Which drugs both inhibit and stim CYP enzymes?
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oxcarbazepine, felbamate, topiramate
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Which drug inhibits P450s?
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valproate
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Which two drugs cause aplastic anemia?
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felbamate, carbamazepine
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