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9 Cards in this Set
- Front
- Back
Alkylating agents
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Bind DNA and interfere with its replications
Cell cycle non specific example: cyclophopphamide |
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Antimetabolites
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inhibits specific enzymes and synthesis of metabolites needed for purine/pyrimidine synthesis
examples: folic acid antagonist: methotrexate Pyrimidine anologs: Fluorouracil, Cytarabine |
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Mitotic inhibitors
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bind to microtubules and inhibit mitosis during M phase
Examples: vincristine* vinblastine |
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Platinum compounds
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bind DNA
cell cycle non specific do not use in cats causes fatal pulmonary edema cisplastin* |
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Antibiotics
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prevent synthesis of DNA
cell cycle non specific excreted in bile myelosuppresssive examples: Doxorubinicin Mithramycin |
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L-Asparaginase
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hormone and hormone antagonists
destroys extracellular L-aspargine which is essential for tumors acts on G1 phase of cell cycle |
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Hormones/antagonists
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little or no myelosuppression
examples: prednisone estrogen, progestins, androgens tamoxifen |
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NSAIDS
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does not cause myelosuppression
interstitial cell carcinoma of urinary bladder in dogs Ex Piroxicam |
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Insecticide
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selective inhibition of adrenal cortex
Example: Mitotane |