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9 Cards in this Set

  • Front
  • Back
Alkylating agents
Bind DNA and interfere with its replications
Cell cycle non specific

example: cyclophopphamide
Antimetabolites
inhibits specific enzymes and synthesis of metabolites needed for purine/pyrimidine synthesis

examples:
folic acid antagonist: methotrexate
Pyrimidine anologs: Fluorouracil, Cytarabine
Mitotic inhibitors
bind to microtubules and inhibit mitosis during M phase

Examples:
vincristine*
vinblastine
Platinum compounds
bind DNA
cell cycle non specific

do not use in cats causes fatal pulmonary edema

cisplastin*
Antibiotics
prevent synthesis of DNA
cell cycle non specific
excreted in bile
myelosuppresssive

examples:
Doxorubinicin
Mithramycin
L-Asparaginase
hormone and hormone antagonists

destroys extracellular L-aspargine which is essential for tumors

acts on G1 phase of cell cycle
Hormones/antagonists
little or no myelosuppression


examples:
prednisone
estrogen, progestins, androgens
tamoxifen
NSAIDS
does not cause myelosuppression

interstitial cell carcinoma of urinary bladder in dogs

Ex Piroxicam
Insecticide
selective inhibition of adrenal cortex

Example:
Mitotane