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9 Cards in this Set
- Front
- Back
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Diazepam
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Benzodiazepime (addictive!)
Fast absorption Metabolized by P450 -> Active metabolites -> glucorinated Active metabolite: desmethyldiazepam t1/2 25-35 minutes |
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Chlordiazepoxide
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Intermediate absorption
Benzodiazepam P450 -> Active metabolites -> glucorinated Active metabolite: desmethyldiazepam t1/2 10 min |
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Flurazepam - prodrug
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Benzodiazepam
Intermediate absorption P450 - active metabolites - glucorniated Active metabolites Converted immediately to active metabolites (t1/2 160 min) |
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Clonazepam
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Intermediate absorption
Probably inactive metabolites 20-50 min half life |
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Alprazolam
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Fast absorption
The metabolism converts the drug to active metabolites Metabolites have an uncertain clinical significance |
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Temazepam
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Slow Absorption
Converted to active metabolites Uncertain clinical significance Benzodiazepam |
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Lorazepam
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Intermediate absorption
Glucorniated Inactive metabolites |
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Oxazepam
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Slow absorption
Benzodiazepmas Glucorinated immediately Inactive metabolites |
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Buspirone
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Azapirone
Highly bound to plasma protein metabolized by hepatic oxidation to active metabolite t1/2 less than 3 hours therapeutic lag: days to weeks Nonsedating profile (better than BZDs) |
