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21 Cards in this Set

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Location of ANS receptors
Nn
Nm
M1-3

Neurotransmitter?
Nicotinic
Nn--in ganglia of PANS and SANS and adrenal medulla

Nm--skeletal muscle motor end plates (somatic NS)

Muscarinic 1-3
all organs/tissues innervated by postganglionic nerves of the PANS(most M3), SA node (M2)
thermoregulatory sweat glands (M1) of SANS

Acetylcholine (ACh)
Norepinephrine (NE)
neurotransmitter at most adrenoceptors in organs as well as in cardiac and smooth muscle
(Alpha or Beta)
Dopamine (DA)
Activates D1 receptors--vasodilation in renal and mesenteric vascular beds
Epinephrine
E--from adrenal medulla
activates most adrenoceptors

Transported in Blood (neurohumoral transmission)
Muscarinic response and receptor in the eye
M3
sphincter--miosis
ciliary muscle--accomodation

(alpha 1--radial muscle--mydriasis)
Muscarinic response and receptor in the heart
M2
SA--decreased heartrate
AV--decreased conduction velocity
(- chronotrophy)
Muscarinic response and receptor in the lungs
M3
bronchioles
contraction--bronchospasm

glands--increased secretion
Muscarinic response and receptor in the GI tract
1. Stomach
2. Glands
3. Intestine
1. M3--increased motility/cramps

2. M1--increased secretion

3. M3--contraction- diarrhea, involuntary defecation
Muscarinic response and receptor in the Bladder
M3 Contraction (detrusor), relaxation (Trigone/Sphincter), voiding, urinary incontinence
Muscarinic response and receptor Sphincter
M3--relaxation
exception: LES contracts
Muscarinic receptor and response in Glands
M3
Secretion--sweat (thermoregulatory)
Salivation
Lacrimation
Muscarinic receptor and response in Blood Vessels
M3
Dilation--via NO/endothelium derived relaxing factor
No innervation, no effects on indirect agonist
Antimuscarinic Drug-prototype
Atropine
Second messanger mechanism for M1 receptor
Gq coupled--DAG and IP3--Ca2+ (intracellular) increases
Second messanger mechanism for M2 receptor
Gi coupled--decreased adenylyl cyclase--decreased cAMP
Second messanger mechanism for Nn and Nm
no second messangers--activation (opening) of Na/K channels
ANS innervation of blood vessels
solely innervated by SANS--stimulation of autonomic ganglia--vasoconstriction (alpha 1)
Blood vessels--effects of stimulation
Adrenergic receptor types and action
Vasoconstriction- PVR, diastolic P afterload increase
alpha 1--arterioles/veins

Vasodilation
beta 2--all vessels

D1--renal and mesenteric-- increased GFR, RBF and Na+ excretion
ANS innervation of GI tract
Dominated by PANS--ganglionic stimulation--increased GI motility and secretions
Adrenergic effects on Beta cells of Islets of Langerhans
Beta 2--increase secretion of insulin

Alpha 2--decreased secretion of insulin
Which adrenergic receptor stimulation inhibits lipolysis
alpha 2
decreased lipolysis and thermogenesis

(alpha 1, beta 1,2 & 3 increase lipolysis and therm)