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21 Cards in this Set
- Front
- Back
Location of ANS receptors
Nn Nm M1-3 Neurotransmitter? |
Nicotinic
Nn--in ganglia of PANS and SANS and adrenal medulla Nm--skeletal muscle motor end plates (somatic NS) Muscarinic 1-3 all organs/tissues innervated by postganglionic nerves of the PANS(most M3), SA node (M2) thermoregulatory sweat glands (M1) of SANS Acetylcholine (ACh) |
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Norepinephrine (NE)
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neurotransmitter at most adrenoceptors in organs as well as in cardiac and smooth muscle
(Alpha or Beta) |
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Dopamine (DA)
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Activates D1 receptors--vasodilation in renal and mesenteric vascular beds
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Epinephrine
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E--from adrenal medulla
activates most adrenoceptors Transported in Blood (neurohumoral transmission) |
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Muscarinic response and receptor in the eye
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M3
sphincter--miosis ciliary muscle--accomodation (alpha 1--radial muscle--mydriasis) |
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Muscarinic response and receptor in the heart
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M2
SA--decreased heartrate AV--decreased conduction velocity (- chronotrophy) |
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Muscarinic response and receptor in the lungs
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M3
bronchioles contraction--bronchospasm glands--increased secretion |
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Muscarinic response and receptor in the GI tract
1. Stomach 2. Glands 3. Intestine |
1. M3--increased motility/cramps
2. M1--increased secretion 3. M3--contraction- diarrhea, involuntary defecation |
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Muscarinic response and receptor in the Bladder
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M3 Contraction (detrusor), relaxation (Trigone/Sphincter), voiding, urinary incontinence
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Muscarinic response and receptor Sphincter
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M3--relaxation
exception: LES contracts |
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Muscarinic receptor and response in Glands
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M3
Secretion--sweat (thermoregulatory) Salivation Lacrimation |
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Muscarinic receptor and response in Blood Vessels
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M3
Dilation--via NO/endothelium derived relaxing factor No innervation, no effects on indirect agonist |
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Antimuscarinic Drug-prototype
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Atropine
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Second messanger mechanism for M1 receptor
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Gq coupled--DAG and IP3--Ca2+ (intracellular) increases
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Second messanger mechanism for M2 receptor
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Gi coupled--decreased adenylyl cyclase--decreased cAMP
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Second messanger mechanism for Nn and Nm
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no second messangers--activation (opening) of Na/K channels
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ANS innervation of blood vessels
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solely innervated by SANS--stimulation of autonomic ganglia--vasoconstriction (alpha 1)
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Blood vessels--effects of stimulation
Adrenergic receptor types and action |
Vasoconstriction- PVR, diastolic P afterload increase
alpha 1--arterioles/veins Vasodilation beta 2--all vessels D1--renal and mesenteric-- increased GFR, RBF and Na+ excretion |
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ANS innervation of GI tract
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Dominated by PANS--ganglionic stimulation--increased GI motility and secretions
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Adrenergic effects on Beta cells of Islets of Langerhans
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Beta 2--increase secretion of insulin
Alpha 2--decreased secretion of insulin |
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Which adrenergic receptor stimulation inhibits lipolysis
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alpha 2
decreased lipolysis and thermogenesis (alpha 1, beta 1,2 & 3 increase lipolysis and therm) |