Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
Ankylosing spondylitis-
Chronic Inflammatory spondyloarthropathy with progressive symptoms of pain and stiffness resulting in severe incapacitating spinal deformity along with systemic Involvement(eyes,lungs,heart,) |
Incidence of Ankylosing spondylitis-
predominantly males (unlike RA) young 13-30 y/o common in European ancestory Native Indians Although any ethnicity can be involved. |
|
Etiology of Ankylosing spondylitis-
Cause is still Unknown. genetic predisposition -Familial HLA B27 (90%) AutoImmune ? |
Pathogenesis of Ankylosing spondylitis-
Hallmark- chronic Inflammation of spine,sternum,sacrum and other large joints leading to pain and stiffness of the back. Central joints of the body is affected. Synovitis of the SI joint and the vertebral facet joints Enthesopathy of the spine and pelvis ligaments Destruction of articular cartilage Inflammation of the fibrous capsule Ossification of the vertebral joints through formation of syndesmophites- that begin in D_Lx region-- bony union - ankylosis Intervertebral discs, symphisis pubis and manubrio-sternal joints may be involved. calcification of ligaments |
|
Pathogenesis of AS-
3 stages involved. Inflammation- fibrosis- ossification (bony union -ankylosis) |
Signs and symptoms of AS-
Early- mild intermittent pain and stiffness in the back with some limitations of ROM Later-Flattening of the Lumbar Lordosis Flattening of the cervical lordosis and kyphosis of the dorsal spine resulting a rounded "C" shaped spine. Spinal movements are completely limited. Reduced chest expansion-asymmetrical decreased Lung capacities |
|
Other organs involved in AS-
Eyes - Irido-cyclitis Uveitis(tearing,pain L/o vision) lungs- pulmonary fibrosis heart- conduction defects Ao Insufficiency/Regurgitation |
Complications of AS-
Neurological- Cauda Equina syndrome cord compression Amyloidosis- Achilles tendinitis Gibbus -angulation of spine decreased VC,TLC Increased RV, FRV Asymmetrical polyarthritis |
|
pain Improves with activity
pain worsens with Inactivity ,Rest Pain is worse at Night. Chest pain (aortitis,, Pulmonary Infection) |
Pain is initially intermittent
later continuous. May mimic symptoms of Lumbago Sciatica, Trochantic Bursitis OA of the Hip , spine |