Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/51

Click to flip

51 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
What bacteria has a resistance to penicillin by changing it OM porins?
P. aeruginosa
Which bacteria have a resistance to penicillins by changing PBP's
MRSA & MRSE
Pneumococci for penicillin G
This anitbiotic inhibits transpeptidation by preventing cross-linking of peptidoglycan chain.
penicillin
Penicillin is bactericidal or bacteristatic
bactericidal
Name the inhibitors of cell wall synthesis
penicillin, cephalosporins, carbapenems, monoboctams (B-lactams) vancomycin, bacitracin, & fosfomcyin (polypeptides)
which antibiotics create hypersensitivity?
ampicillin and cephalosporins
What class of antibiotic is B-lactam resistant?
Class II (very narrow spectrum)
MRSA and MRSE are treated with?
Vancomycin
Anti-staph antibiotics?
very narrow spectrum (class II) methicillin, nafcillin oxacillin, cloxacillin, and dicloxacillin.
Drug of choice for gram + and - cocci?
narrow spectrum (class I)
Extended spectrum drugs are used w/ penicillinase inhibitors. What are they?
amoxicilln + clavulanic acid (Augmentin): PO
ampicillin + sulbactam: IV
ticarcillin + clavalanic acid (Timentin):IV
Peperacillin + tazobactam:IV
Why do we use aminoglycosides in combination with penicillins and cephalosporins?
1) inhibition of cell wall syn thus enhanced antimicrobial activity of aminoglycosides.
Antibiotic used to treat oropharingeal infections.
Penicillin V
Standard penicillins not active against .....
negative bacilli
Active against spirochetes and + bacilli.
narrow spectrum penicillins
Drug combo for enterococcal endocarditis. (necessary)
Peni G and aminoglycoside
Drug combo for meningitis caused by P. aeruginosa.
Cephalosporins and aminoglycosides.
Drug combo for pseudomonal infections.
Antipseudomonal penicillin and aminoglycoside.
MOA's of penicillins
1) inactivation of transpeptidases
2) peni binding proteins
3) prevent cross-linking of peptidogylcans
Bacteria that form penicillinases
Staph
E.coli
H. influenza
Three drugs used for UTI's
-aminopenicillins (extended spectrum)
-quinolones
-sulfonamides
Used for UTI's, sinusitis, otitis, and lower respiratory infections.
Aminopenicillins (extended spectrum)
Drug of choice for L. monocytogenes
Aminopenicillins
Absorption characteristic of penicillin.
poor absorption via oral except for amoxicillin and peni V
oral forms of penicillin
peni V and amoxicillin
depot forms of penicillins
procraine peni G and benzathine peni G
Distribution of penicillin
poor CNS penetration
cross placenta- not teratogenic
This chemical prevents excretion of penicillin.
probenicid.
What is the drug of choice used as a prophylactic of orhtopedic, abdominal, and pelvic surgeries.
1st generation cephalosporins
what are the dna repair and genomic insability disorder in cancer?
BCLA 1 and 2 and HNPCC for dna repair and blooms syndrome, ataxia-telangiectasia, fanconi anemia, and xermoderma pigmentosa.
BH
BAFX
What is the drug of choice for Enterococus faecalis.
imipenem/cilasatin
(most broad-spectrum drug)
What is the most broad spectrum antibiotic
imipenem/cilastain
Chloramphenicol is broad spectrum with what other antibiotic?
tetracycline
contraindicated in pregnancy, breast feeding women and children under 8.
tetracycline (deposits in primary teeth and growing bones of children)
Antibiotic with phototoxicity
tetracycline
Antibiotic that produces local tissue toxicity.
tetracycline
Bacteria confer resistance by pumping out the drug and preventing intracellular accumulation to this antibiotic.
tetracycline
Toxicity of this antibiotic is phlebitis, "Red man syndrome", chills, and fever.
vancomycin
This antibiotic produces phototoxicity as a side effect.
tetracycline
These two antibiotics may cause pseudomembranous colitis.
clindamycin and penicillin
This antibiotic may cause irreversible ototoxicity.
aminoglycosides
Aminoglycosides are administered parenterally except for two. Which are they?
Neomycin and Kanamycin (topical)
These antibiotics are special in that they have a postantibiotic effect.
aminoglycosides
Where are aminoglycosides found in high concentrations?
renal cortex
endolymph and perilymph of inner ear.
This combo of drugs is used as first-line therapy for acute toxoplasmosis.
sulfadiazine (antibiotic) and pyrimethamine (antiparasite)
This antibiotic is used to treat bacterial conjuntivitis.
sodium sulfacetamide
Azithromycin and clarithromycin are what type of antibiotic?
Macrolides (moderate spectrum)
Used to prevent sepsis in burn patient and pt's with wounds.
mafenide acetate but silver sulfadiazine is less toxic and preffered
True or false. The preferred method of administration of erythrmycin is parenteral.
false - oral as enteric coated.
Used to treat UTI's of E.coli and P. mirabilis
sulfonamides.
Who Takes Care of Pseudomonas?
Ticarcillin Carbenicillin, and Piperacillin.