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13 Cards in this Set
- Front
- Back
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tissue provide signals Endothelial Cells responds by
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producing proteases--> digest their way through basal lamina of capillary migrating towards source of signal proliferating form tubes differentiating |
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in low O2 there is high levels of Hypoxia Induced Factor ... leading to |
HIF induces VEGF EC senses it transcription elements activated sprouts towards cells |
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VEGF exerts effects by |
binding to and activating structurally related membrane receptor TK |
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VEGFR3 located at |
lymphatic EC |
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VEGFR1 and 2 expressed on surface of |
blood EC |
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VEGF-A binds to |
VEGFR1 and 2 |
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PIGF and VEGF-B interact only with |
VEGFR1 |
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VEGF-C/D bind to |
VEGFR3 proteolytic processing: might bind to VEGFR2 |
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VEGFR2 is the major mediator of... |
EC mitogenesis, survival and microvascular permeability |
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VEGFR1 role |
inhibitory role by sequestering VEGF and prevent its interaction with VEGFR2
regulate expression of variety of genes in endothelium such as MMP9 and certain growth factors |
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activators of VEGF synthesis |
EGF IGF-1 PDGF H2O2 IL6 bFGF Hypoxia COX2 increase NO increase oncogenes |
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process of angiogenesis via VEGF |
VEGF binds to VEGFR2 TK signaling cascade stimulate production of: factors that stimulate vessel permeability produced: eNOS producing NO proliferation/ survibal: bFGF migration: ICAMs / VCAMs/MMPs
finally differentiaton into mature blood vessels |
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Bevacizumab |
binds to and neutralises all human VEGF-A isoforms |
