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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What are the key events in repair by connective tissue deposition?
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inflammation
angiogenesis migration and proliferation of fibroblasts scar formation connective tissue remodelling |
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What are the mechanisms of angiogenesis?
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Angiogenesis from existing vessels
Angiogenesis from endothelial precursor cells |
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What growth factor receptors are involved in angiogenesis?
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VEGF
DLL4 |
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What are the effects of VEFG blockade?
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Vascular organisation
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What are the effects of DLL4 blockade?
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Sprouting and EC proliferation
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How are new formed vessels stabilised?
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Pericyte and smooth muscle recruitment
Deposition of ECM proteins |
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What ECM proteins regulate angiogenesis?
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Intergrins - for blood vessel formation
matricellular proteins - destabilise cell-matrix interactions proteinases - tissue remodelling and endothelial invasion |
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What are the three phases of cutaneous wound healing?
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inflammation
proliferation maturation |
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What are the events in wound healing?
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Formation of clot
Formation of granulation tissue Cell proliferation and collagen deposition Scar formation Wound contraction Connective tissue remodelling |
Events in wound healing can be clumped into phases
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What are two types of cutaneous wound repair
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Healing of thin wound
Healing of complicated excisional wounds |
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What local and systemic factors influence wound repair?
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local - infection, mechanical forces, foreign bodies, dimension
Systemic - Nutrition, metabolic status, circulatory status, hormones |
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What are the consequences of aberrant repair?
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Inadequate granulation tissue and scar assembly
Excessive formation of repair components Contractures |
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What is the cause of fibrosis?
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Persistent injury
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What compounds are important in fibrosis?
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Osteopontin
TGF-B |
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Why do fetal cutaneous wounds heal without scarring?
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?lack of osteopontin
?non-fibrogenic forms of TGF-B ?absence of a TH2 response |
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