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23 Cards in this Set
- Front
- Back
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What is a minimal alveolar concentration
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CONCENTRATION OF a Inhaked anesthetic as a % of inspired air @ which 1/2 who dont respond to a surgical stimulus
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What is halothane (.8 MAC_)
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Halothane sensitizes the <3 to catecholaminws
can cause malignant hyperthermia of <3 arrythmias |
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Nitrous oxide (MAC 104%)
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Rapid onset and recovery no metabolism..spon. abortions and diffusional hypoxia
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What is MAC
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MAC = Potency
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Charachteristics of MAC
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MORE LIPID SOLIBLE LOWER MAC adn GREATER potency
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WHAT are anethetics with HIGH blood-gas ratios ass. w/
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SLOW onset and slow recovery
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What is THoiopentol
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It is a barbituate used for inducation: Highly lipid soluble
Rapid onset and SHORT acting |
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What is Midolazam used for
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Maint. of Anesthesia
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What is Ketamine used for
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NMDA receptor antagonist
Increases Intercranial pressure |
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What drugs are Esters
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COCAINE, PROCAINE,
BENZOCAINE which are metabolised by plasma and tissues esterases |
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What are amides
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Local anesthesetics
LIDOCAINE, BUPIVIACAINE, MEPIVIACAINE they r metabolized by liver amidases |
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How do alpha-1 agonists affect the absorption of Local anesthetics
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Coadmin. of alpha-1 agonists
Dec. Local anesthetic absorption into systemic circulation. prolongs effects and toxicity |
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What are the side effects of local anesthetics
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Neurotoxicity
<3 tox Allergies |
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What does cociane do
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INTrinsically causes VASOconstriction by blocking NE uptake
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Which nerve fibers are MOST affected by local anesthetics
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Types B and C A delta
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Which Na+ channel toxins
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Tertrodoxtoxin and Saxitoxin
Block activated Na+ channels and Decrease Na+ influx |
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What is Ciguatoxin
and brachotoxin |
Bind to act. Na+ channels and cause inactivation
Prolong Na+ influx |
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What does Atracurium do
(NON-DEPOL) |
It is a skeletal muscle relaxant
which is SPONTANeously inactivated to Laudanssine Laudosine--> Siezures |
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IS Nondepolarizing Skeltal muscle relaxants Reversible with ACHe inhbitors
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YES
they have no cns effects |
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What is Succinylcholine
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It is DEPOLarizing NON-competetive
Phase I" Depolarization. fasciculation..flaccid paralysis Phase II: Desensitation |
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What are the CENTRAL skeletal muscle relaxants
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GABA A" Benzo
GABA B: Baclofen |
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What is malignant hyperthermia
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It is LYFE threatening
muscle ridigity, acidosis, hyperkalemis, hypertension, hyperthermia can be related to gene's ass. w. ryanodine receptor and or pt. of the L-type Ca2+ channel in the skeletal muscle TX: Dantrolene: Blocks Ca2+ release from the SR |
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What are the 3 drugs implicatedx in Maligant Hyperthermia
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Succinylcholien, Halothane, Turbocuraine
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