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57 Cards in this Set

  • Front
  • Back
Propofol MOA
enhances effect of GABA
CNS depression
Iso cardio effects vs Sevo
arrhythmias
minor, some arrhythmias
Diazepam is _____ potent than Lorazepam
less
Alpha 2 agonists produce
sedation
analgesia
muscle relaxation
Does propofol have analgesic effects
NO!
Diazepam can be reversed wtih
Flumazenil
Alpha 2 agonist MOA
bind Alpha 2 receptors prevent the release of more norepinephrine
Propofol advantages
fast induction
rapid redistribution,
Which opioids cause decreased GI motility
Mu Kappa
Flumazenil is a
competative antagonist of BZD
Alpha 2 effects
cardio - postsynaptic action - vasoconstriction - increase BP, then decrease HR, the pre-synaptic action decreasing BP )Biphasic action)
Resp - depressed
Urinary output reduced via Renin/ADH
Propofol effects
CNS depression
Decrease intracranial and intraocular pressures
decrease blood pressure
respiratory depression

APNEA
Which opioids cause sedation?
Mu, Kappa
An increased dose of Alpha 2 agonist produces
longer effect and amount of sedation and analgesia
Does propofol cause muscle relaxation?
No
Midazolam undergoes
glucoronidation but can still use in cats - alternate pathway.
Xylazine
approved for dogs, cats, horses, deer, & elk.
Least selective
Produces more ataxia in horses than detomidine
Flumazenil MOA
not a barbituate, it decreases Cl conductance
Cattle reaction to xylazine
very sensitive
have alpha 2D receptors
1/10 the dose
Does Etomidate cause analgesia or muscle relaxation
NO!
Benzodiazapines are NOT
analgesic.
Detomidine
Approved in horses
injectable for sedation & analgesia
More potent and longer acting than xylazine
Etomoidate effects
Minimal CVS or respiratory changes
decrease intracranial and intraocular pressures
Benzodiazapines are
used as muscle relaxants, decrease seizures, decrease anxiety, sedation
Alpha 2 agonists with ketamine produces
less cardiac effects because ketamine increases HR and balances decrease caused by decrease in HR
Adverse effects of BZDs
vocalization, excitation, mmfasciculations, ataxia, then sedation, disinhibition, increased apetite
Which opioids cause respiratory depression
Mu
Which opioids cause nausea/vomiting/decrease biliary secretions?
Mu
Propofol CVS effects
stimulates arrhythmias
If patient has heart problems what is the best anesthetic?
etomidate
Etomidate redistributes to
Muscle
NOT fat.
Morphine is
Mu agonist
used for analgesia/premed/sedative
Termination of the effects of Propofol occurs when
drug has redistributed to muscle/fat/etc.
Hydromorphone
Mu agonist
More potent than morphine, increased lipophilicity, less emetic
Which injectable anesthetic is best to use in heart patients and why?
Etomidate
doesn't cause arrythmias
Fentanyl
Mu agonist
Minor CV effects, but dose-dependent respiratory depression
Buprenorphine
Mu agonist
analgesia, sedation, euphoria, GI effects, resp depression
Tramadol
Mu agonist - SSNRI
antitussive, sedation, nausea, vomiting.
Butorphanol
Kappa agonist - partial mu agonist
well tolerated in horses
mild/moderate analgesia
antitussive in dogs
What opioid is only a mu agonist
Fentanyl
What opioid is only a partial Mu agonist
Buphrenorphine
What is a mu agonist, serotonin, and norepi reuptake inhibitor
Tramadol
What is a partial Mu agonsit and full Kappa agonist?
Nalbuphine
To get analgesia w/o respiratory effects use
K agonist
Butorphanol, and Nalbuphine
The opioid receptors are located
in the CNS
Premed sedation and anxiolysis goals
Facilitate animal handling
decrease stress
safe for handler and animal
Acepromazine drug class
Phenothiazine
Acepromazine effects
Depress vasomotor reflexes - hypotension
anti-emetic
Acepromazine metabolized in
liver
Alpha 2 CV effects
hypotension
decrease sympathetic flow
arrhythmias
Do alpha 2 cause muscle relaxation
yes
What drugs cause muscle relaxation?
Alpha 2
Benzodiazepines
propofol
What drug increases blood glucose
Alpha 2
do benzodiazepines cause muscle relaxation?
yes
Benzodiazapines are metabolized in
the liver
etomidate is good with what conditions and be careful with what conditions
Good with Cardiac
Careful with addisonian
Ketamine's effect on PCO2
Increases PCO2 - don't use with neuro case and Increases ICP
May induce seizures - not with epilepsy