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14 Cards in this Set
- Front
- Back
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What type of anemia is caused by iron deficiency?
By what mechanism? |
Microcytic, hypochromatic
Decreased formation of hgb d/t decreased iron |
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What type of anemia is caused by B-12 deficiency?
By what mechanism? |
Megaloblastic
Impaired DNA, CHO and lipid synthesis. |
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What type of anemia is caused by folic acid deficiency?
By what mechanism? |
Megaloblasic
Impaired DNA synthesis. |
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What is acute iron deficiency?
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Disorder that occurs in children. Iron errodes gastric mucosa entering directly into circulation. Can be lethal, if there is survival there is extension GI scarring.
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What is chronic iron deficiency?
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Occurs primarily in adults. Usually there is a genetic disorder (thalassemia major, hemochromotosis). Normally very difficult to get toxic from ingestion of iron.
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What is the basic cause of B-12 deficiency?
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Lack of intrinsic factor in the stomach. B-12 needs to bind to it to be absorbed.
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What happens if B-12 deficiency is not corrected?
(besides anemia) |
GI problems
Demylenation of nerves due to impaired lipids. This results in cell death. |
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Why are the RBC's very large with B-12 deficiency?
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There is impaired DNA synthesis which causes impaired cell division. They do not get to divide as they should, so they remain large.
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Will you see nerve demylenation with folic acid deficiency? Why or why not?
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No. It is not involved in the synthesis of succinyl CoA.
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What may happen if you treat a vitamin B-12 deficiency with large doses of folic acid?
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The anemia will be corrected by it will not prevent neurological damage.
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How does folic acid correct a B12 deficiency anemia?
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By bypassing the CH3H4-folate step.
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What mimics erythropoetin?
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Epoetin alfa and darbepoetin alfa
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What are the consequences of chemotherapy?
What is the treatment |
Anemia, neutropenia, thrombocytopenia
Epoetin alfa, filgrastim, oprelvekin |
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Why is there anemia is chronic renal failure?
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The kidneys are damaged and cannot make erythropoetin.
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