Anemia Notes From Lecture

Front 1

1. serum iron low, TIBC high, ferritin low
   
2. serum iron low, TIBC low, ferritin high/N
3. serum iron high, TIBC low/N, ferritin high

Back 1

1. Iron deficiency anemia
2. Anemia of chronic inflamation
3. sideroblastic anemia

Front 2

1. Impaired DNA synthesis?
   
2. Common causes?
3. Type of anemia
4. MCV

Back 2

1. megaloblastic anemia
2. B12 and folate deficiency
3. Macro/normo
4. MCV > 110 fl

Front 3

• Macrocytic anemia with unimpaired DNA synthesis
  
• MCV?
• Causes

Back 3

• non-megaloblastic anemia
  
• MCV 100-110
• reticulocytosis, liver disease, alcoholism

Front 4

• define aplastic anemia
• 3 types

Back 4

• pancytopenia of peripheral blood
• idiopathic, acquired, hereditary

Front 5

Aplastic anemia

1. Fanconi anemia
   
2. Diamond-blackfan syndrome

Back 5

1. autosomal recessive, leads to AML
2. congenital pure RBC aplasia due to defective stem cell unable to commit to a precursor

Front 6

What causes congenital dyserythropoietic anemia and how is it characterized?

Back 6

• Caused by changes in erythroid cell nuclear membrane and chromatin pattern.
  
• characterized by bizarre multinucleated erythroblasts

Front 7

What is anemia associated with marrow infiltration (myelophthisic anemia).

Back 7

bone marrow infiltrated by abnormal cells or tumor that crowd out normal blood cell precursors.

Front 8

What is hydremia? Cause?

Back 8

a relative anemia due to increase in plasma volume. Caused by pregnancy, hyperproteinemia, massive IV or FFP infusion

Front 9

1. What is hereditary spherocytosis caused by?
   
2. How to diagnose?

Back 9

1. spectrin and ankyrin defect cause RBC to lose membrane
2. Spherocytes in PB, MCHC >36%, osmotic fragility high, DAT negative

Front 10

Cause of hereditary elliptocytosis?

Back 10

defect involving alpha or beta chain spectrin which affect RBC deformability

Front 11

1. Cause of hereditary pyropoikilocytosis
   
2. Clinical picture

Back 11

1. Defect in alpha or beta spectrin due to mutation
   
2. Mishapen, budding, fragmented cells that fragment when heated over 45 C.

Front 12

Hereditary xerocytosis

Back 12

Dehydrated cells that lose K due to unknown RBC permeability defect

Front 13

Hereditary acanthocytosis

Back 13

abetalipproteinemia, or abnormal membrane lipids

Front 14

What is G6PD deficiency associated with?

Back 14

Fava beans, and alternative drugs

Front 15

PB with bite cells due to denatured Hgb, and Heinz bodies.

Back 15

G6PD deficiency

Front 16

1. Cause defect in hexose monophosphate pathway from oxidative damage
2. Cause defect to embden-meyerhof pathway

Back 16

1. G6PD deficiency
2. pyruvate kinase deficiency

Front 17

• Antibody seen in cold autoimmune hemolytic anemia
  
• clinical picture

Back 17

• anti-I
  
• spherocytes, MCHC > 36 g/dL, agglutination on smear, DAT postive

Front 18

IgG binds to RBC at low temperature. Hemolysis occurs when body temp increases

Back 18

Paroxysmal cold hemoglobinuria (PCH)

Front 19

Associated with Donath Landsteiner Ab (anti-P)

Back 19

Paroxysmal cold hemoglobinuria