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23 Cards in this Set
- Front
- Back
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Preferred method of giving Fe?
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oral (iv can cause allergy)
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Functions of hepcidin?
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keeps iron in storage and decreases absorbtion
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What increases hepcidin production?
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high iron/tibc; TNF; inflamm/infxn
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What drugs are ass w/folate deficiency?
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phenytoin, pyrimethamine, mtx (leucovorin)
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What is diamond-blackfan syndrome?
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congenital pure red cell aplasia
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Thymoma is associated with what hematological abnormality/
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pure red cell aplasia
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What is a crenated cell and what is it associated with?
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spiky RBC with central pallor, ass w/kidney dz
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What is an acanthocyte and what is it ass w/?
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spiky RBC w/o central pallor, ass w/liver dz
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Findings in myelophthisic anemia?
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teardrop rbcs and leukoerythroblastosis
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What causes leg uclers?
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sickle cell AND HerSPheroCYT
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What hematological d/o does cholelithiasis indicate?
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chronic hemolytic anemias (like hered sherocyto)
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Tx for hereditary spherocytosis?
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splenectomy and polyvalent vaccine (transfusion if in aplastic crisis)
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Defect in hered stomatocytosis?
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na pump problem
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Name the dz: kid is fine then gets severe hemolytic anemia with fever?
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hereditary pyropoikilocytosis
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inheritance pattern of g6pd def?
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sex linked
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What are heinz bodies ass w?
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g6pd, thal, others? Unstable Hb
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What are Howel -Jolly bodies?
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nuclear remnants causing small round inclusions in RBCs…indicative of ASPLENIA
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Difference btwn direct and indirect antiglobin test?
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direct looks on RBCs and is for autimmune; indirect looks in serum and is for alloimmune
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Tx for warm AIHA?
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prednisone, splenectomy, immunosuppressives
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Tx cold Ab type hem anem?
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tx underlying chronic lymphoprolif or…if no underlying, keep the pt warm
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Clinical morphologic features of PK def?
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none
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Name the dz: adverse effects of anemia are offset by increased 2,3-BPG?
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PK deficiency
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How does PK deficiency cause anemia?
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decreased ATP production leads to increased permeability and DEATH
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