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159 Cards in this Set

  • Front
  • Back
True or false: Mesoderm gives rise to muscle, bone, and blood.
true
True or false: Columnar cells lining the small intestine show a brush border of microvilli on the apical surface.
true
True or false: Nonkeratinized cells exfoliate from the surface of the skin.
false
True or false: In an epithelium, there is almost no extracellular matrix.
true
True or false: The clear gel that usually surrounds cells is called interstitial fluid.
true
True or false: Fibrocartilage is found in intervertebral discs.
true
True or false: Blood consists of cells and a ground substance made of formed elements.
false
True or false: Plasma cells produce the ground substance that forms the matrix of connective tissues.
false
True or false: Excitable cells respond to outside stimuli by means of changes in plasma membrane shape.
false
True or false: Smooth and cardiac muscles are under involuntary control.
true
True or false: Dendrites in a neuron send outgoing signals to other cells.
false
True or false: Desmosomes are more effective than tight junctions in preventing substances from passing between cells.
false
True or false; The duct of an endocrine gland leads into the bloodstream rather than onto an epithelial surface.
false
True or false: The secretory product of a gland is produced by its parenchyma, not its stroma.
true
True or false: Scar tissue helps to hold an organ together but does not restore normal function of the damaged tissue.
true
There are 50 trillion cells of ______ different cell types.
200
List the four broad categories of tissues.
epithelial tissue

connective tissue

nervous tissue

muscular tissue
What is a structure with discrete boundaries that is composed of two or more tissue types?
organ
What is a group of similar cells and cell products that arise from the same region of the embryo and work together to perform a specific structural or physiological role in an organ?
tissue
In what ways do the four primary tissues differ from one another?
types and functions of their cells
characteristics of the matrix (extracellular material)
relative amount of space occupied by cells versus matrix
What is the matrix (extracellular material) composed of?
fibrous proteins

clear gel called ground substance, tissue fluid, extracellular fluid (ECF), interstitial fluid, or tissue gel
In what form does human development begin?
single cell -- fertilized egg

divides to produce scores of identical, smaller cells

first tissues appear when these cells start to organize themselves into layers: first two, then three strata
What are the 3 primary germ layers?
Ectoderm (outer) --> gives rise to epidermis and nervous system

Endoderm (inner) --> gives rise to mucous membrane lining, digestive and respiratory tracts, digestive glands, etc.

Mesoderm (middle) --> becomes gelatinous tissue called mesenchyme; wispy collagen fibers and fibroblasts in gel matrix; gives rise to muscle, bone, blood.
Describe the ectoderm germ layer.
(outer) gives rise to epidermis and nervous system
Describe the endoderm germ layer.
(inner) gives rise to mucous membrane, digestive and respiratory tracts, digestive glands, etc.
Describe the mesoderm germ layer.
(middle) becomes gelatinous tissue called mesenchyme

wispy collagen fibers and fibroblasts in the gel matrix

gives rise to muscle, bone, blood
Which tissue section consists of tissue sliced into thin sections one or two cells thick?
histological sections
Which tissue section consists of tissue mounted on slides and artificially colored with histological stain?
stains
Sectioning reduces 3-dimensional structure to ___________________.
2-dimensional slice
Which tissue section consists of tissue cut along long direction of organ?
longitudinal section (l.s.)
Which tissue section consists of tissue cut perpendicular to length of organ?
cross section (c.s. or x.s.) or transverse section (t.s.)
Which tissue section consists of tissue cut at angle between cross and longitudinal sections?
oblique section
Which tissue section consists of tissue rubbed or spread across slide? Give examples.
smear

spinal cord or blood
Which tissue section consists of cobwebby tissue laid out on slide? Give examples.
spread

areolar tissue
Which form of tissue consists of a flat sheet of closely adhering cells and is one or more cells thick?
epithelial tissue --> covers body surface and lines body cavities

upper surface is usually exposed to the environment or an internal space in the body

forms the external and internal linings of many organs
Which form of epithelial tissue contains 1 layer of cells and is named by the shape of cells?
simple epithelium --> all cells touch the basement membrane
Which form of epithelial tissue contains more than 1 layer of cells and is named by the shape of apical cells?
stratified epithelium --> some cells rest on top of others and do not touch basement membrane
Name and describe the 4 types of simple epithelia.
simple squamous (thin, scaly cells)
simple cuboidal (square or round cells)
simple columnar (tall, narrow cells)
pseudostratified columnar (shorter cells are covered by taller ones; all cells reach the basement membrane)
What are wineglass-shaped mucus-secreting cells In simple columnar and pseudostratified epithelia?
goblet cells
Which form of simple epithelia permits rapid diffusion or transport of substances and secretes fluid?
simple squamous epithelium --> single row of thin cells

alveoli, glomeruli, endothelium, and serosa
Which form of simple epithelia functions for absorption and secretion, mucus production, and movement?
simple cuboidal -> single layer of square or round cells

liver, thyroid, mammary and salivary glands, bronchioles, and kidney tubules
Which form of simple epithelia contains a brush border of microvilli ciliated in some organs, may possess goblet cells, and functions for secretion and absorption as well as the secretion of mucus?
simple columnar epithelium --> single row of tall, narrow cells

oval nuclei in basal half of cell

lining of GI tract, uterus, kidney, and uterine tubes
Which form of simple epithelia contains nuclei at several layers, cilia and goblet cells, and secretes and propels mucus?
pseudostratified epithelium --> looks multilayered, some not reaching free surface; all touch basement membrane

respiratory tract and portions of male
Which form of tissue consists of some cells resting directly on others allowing only the deepest layer to reach the basement membrane, and consists of 2-20 or more layers of cells?
stratified epithelia

Three stratified epithelia are named for the shapes of their surface cells.
stratified squamous
stratified cuboidal
stratified columnar (rare)

4th type: transitional epithelium
What is the most widespread epithelium in the body?
stratified epithelia
The deepest layers of stratified epithelia undergo continuous _____________. Explain.
mitosis

Their daughter cells push toward the surface and become flatter as they migrate farther upward.

finally die and flake off through exfoliation or desquamation
Describe the two kinds of stratified squamous epithelia.
keratinized --> found on surface of skin, abrasion resistant

nonkeratinized --> lacks surface layer of dead cells
Which form of stratified epithelia resists abrasion, retards water loss through skin, and resists penetration by pathogenic organisms?
keratinized stratified squamous --> flat and scaly surface

epidermis; palms and soles heavily keratinized
Which form of stratified epithelia resists abrasion and penetration of pathogens?
nonkeratinized stratified squamous

tongue, oral mucosa, esophagus, and vagina
Which form of stratified epithelia secretes sweat and produces sperm and ovarian hormones?
stratified cuboidal epithelium --> surface cells square or round

sweat gland ducts, ovarian follicles, and seminiferous tubules
Which form of stratified epithelia allows for filling of urinary tract?
transitional epithelium --> change from round to flat when stretched

ureter and bladder
What is a type of tissue in which cells usually occupy less space than the extracellular material and binds organs to each other, and supports and protects organs?
connective tissue --> highly vascular (richly supplied with blood vessels)

most abundant, widely distributed, and histologically variable of the primary tissues

Most cells of connective tissue are not in direct contact with each other (separated by extracellular material)
What are the functions of connective tissue?
binding of organs such as tendons and ligaments

support bones and cartilage

physical protection of the cranium, ribs, and sternum

immune protections -- white blood cells attack foreign invaders

movement -- bones provide lever system

storage of fat, calcium, and phosphorus

heat production -- metabolism of brown fat in infants

transport blood
What is another word for white blood cells?
leukocytes

neutrophils wander about attacking bacteria

lymphocytes react against bacteria, toxins, and other foreign material
Which form of fibrous connective tissue produce fibers and ground substance?
fibroblasts
Which form of fibrous connective tissue phagocytizes foreign material and activate the immune system when they sense foreign matter or antigens?
macrophages --> arise from white blood cells called monocytes
Which form of fibrous connective tissue synthesizes disease-fighting antibodies?
plasma cells --> arise form lymphocytes
Which form of fibrous connective tissue is found alongside blood vessels?
mast cells --> secrete heparin to inhibit clotting; secrete histamine to dilate blood vessels
Which form of fibrous connective tissue stores triglycerides or fat molecules?
adipocytes
Which fibers are tough, flexible, and resist stretching, are found in tendons, ligaments, and deep layer of the skin?
collagenous fibers --> most abundant of the body's proteins (25%)
Which fibers are thin collagen fibers coated with glycoprotein that form the framework of organs such as the spleen and lymph nodes?
reticular fibers
Which fibers are thinner than collagenous fibers, branch and rejoin each other, are made of protein called elastin, and allows stretching and recoiling?
elastic fibers

yellow fibers - fresh elastic fibers
What is a long polysaccharide composed of unusual disaccharides called amino sugars and uronic acid which plays an important role of regulating water and electrolyte balance in the tissues?
glycosaminoglycans (GAGs)
What is the most abundant GAG and what is its function?
chondroitin sulfate --> in blood vessels and bone

responsible for stiffness of cartilage
Ground substance is usually a gelatinous to rubbery consistency resulting from three classes of large molecules. What are these 3 classes?
glycosaminoglycans (GAGs)

proteoglycans

adhesive glycoproteins
What is a gigantic molecule shaped like a test-tube brush that forms thick colloids which create strong structural bonds between cells and extracellular macromolecules?
proteoglycans --> holds tissues together
Which form of fibrous connective tissue is composed of loosely organized fibers, abundant blood vessels, and a lot of seemingly empty space?
areolar tissue

underlies all epithelia, in serous membranes, between muscles, passageways for nerves and blood vessels
Nearly every epithelium rests on a layer of ____________ tissue.
areolar
Which form of fibrous connective tissue is composed of reticular fibers and fibroblasts and forms supportive stroma (framework) for lymphatic organs?
reticular tissue --> loose connective tissue

found in lymph nodes, spleen, thymus, and bone marrow
Which form of fibrous connective tissue is composed of densely packed, parallel collagen fibers, and compressed fibroblast nuclei?
dense regular connective tissue

elastic tissue/fibers wavy sheets

Tendons attach muscles to bones and ligaments hold bones together.
Which form of fibrous connective tissue is composed of densely packed, randomly arranged, collagen fibers and few visible cells that withstands unpredictable stresses?
dense irregular connective tissue

deeper layer of skin; capsules around organs
What is the body's primary energy reservoir?
fat

The quantity of stored triglycerides and the number of adipocytes are quite stable in a person.
What is the space between adipocytes occupied by?
areolar tissue, reticular tissue, and blood capillaries
Which form of tissue provides thermal insulation, anchors and cushions organs such as eyeballs and kidneys, and contributes to body contours (female breast and hips)?
adipose tissue --> empty-looking cells with thin margins

On average, women have more fat than men. Too little can reduce female fertility.

Most adult fat is called white fat.
What is the heat-generating tissue found in hibernating animals, fetuses, infants, and children?
brown fat
What is the supportive connective tissue with flexible, rubbery matrix that gives shape to ear, tip of nose, and larynx?
cartilage

Chondroblasts produce matrix and surround themselves until they become trapped in little cavities (lacunae).
What are the cartilage cells in lacunae?
chrondrocytes
What is the sheath of dense irregular connective tissue that surrounds elastic and most hyaline cartilage?
perichondrium --> surrounds elastic and most hyaline cartilage (NOT articular cartilage)

contains a reserve population of chondroblasts that contribute to cartilage growth throughout life
Which process bring nutrients and removes wastes from cartilage?
diffusion (because it has no blood vessels)

Cartilage heals slowly.
Which form of cartilage eases joint movement, hold airway open, moves vocal cords during speech, and has a clear, glassy microscopic appearance because of unusual fineness of the collagen fibers?
hyaline cartilage --> usually covered by perichondrium

articular cartilage, costal cartilage, trachea, larynx, fetal skeleton
Which form of cartilage contains elastic fibers and provides flexible, elastic support to the external ear and epiglottis?
elastic cartilage --> covered with perichondrium
Which form of cartilage contains large, coarse bundles of collagen fibers, resists compression, and absorbs shock?
fibrocartilage --> never has perichondrium

pubic symphysis, menisci, and intervertebral discs
What are the two meanings of bone?
an organ of the body

femur, mandible composed of multiple tissue types
What makes up most of the mass of bone?
osseous tissue (bone tissue)
Which form of osseous tissue consists of delicate struts of bone called trabeculae and is found in heads of long bones and in middle of flat bones such as the stenum?
spongy bone --> covered by compact bone; spongy in appearance
Which form of osseous tissue is a dense, calcified tissue with no visible spaces in which the cells and matrix surround vertically oriented blood vessels in long bones?
compact bone --> more complex arrangement
What is the central canal of the bone and its surrounding lamellae?
osteon
Where is bone matrix deposited?
concentric lamella
Compact bone is arranged in cylinders that surround ___________________ that run longitudinally through shafts of long bones.
central (haversion or osteonic) canals
What are mature bone cells that occupy the lacunae?
osteocytes
What are delicate canals that radiate from each lacuna to its neighbors, and allow osteocytes to contact each other?
canalculi
What is tough fibrous connective tissue that covers the bone as a whole?
periosteum
Which form of connective tissue transports cells and dissolved matter from place to place?
fluid connective tissue
What is the term that describes blood's liquid ground substance?
plasma
What is another word for red blood cells?
erythrocytes --> transport O2 and CO2
What are the cell fragments involved in clotting and other mechanisms?
platelets
Excitability is a characteristic of all living cells. Which systems is this characteristic developed to the highest degree?
excitability
What is the electrical charge difference (voltage) that occurs across the plasma membranes and is the basis for their excitation?
membrane potential
How do nerves respond to changes in membrane potential?
rapid transmission of signal signals to other cells
How do muscles respond to changes in membrane potential?
contraction, shortening of the cell
Which part of the neuron houses nucleus and other organelles and is the cell's center of genetic control and protein synthesis?
neurosoma
Which part of the neuron consists of multiple short, branches processes that receive signals from other cells, and transmit messages to neurosoma?
dendrites
Which part of the neuron sends outgoing signals to other cells?
axon (nerve fiber) --> can be more than a meter long
Which form of tissue is specialized for communication by electrical and chemical signals?
nervous tissue --> consists of neurons (nerve cells) and neuroglia
Which cells in nervous tissue detect stimuli, respond quickly, and transmit coded information rapidly to other cells?
neurons (nerve cells)
Which cells in nervous tissue protect and assist neurons, and are considered "housekeepers" of the nervous system?
neuroglia (glial)
Which form of tissue consists of elongated cells that are specialized to contract in response to stimulation?
muscular tissue --> primary job is to exert physical force on other tissues and organs

creates movements involved in body and limb movement, digestion, waste elimination, breathing, speech, and blood circulation

important source of body heat
What are the 3 types of muscle?
skeletal
cardiac
smooth
Which form of muscular tissue is composed of long, threadlike cells called muscle fibers, contains striations, and is voluntary?
skeletal muscle --> striations, voluntary

most attach to bone

containing multiple nuclei adjacent to plasma membrane
Which form of muscular tissue is limited to the heart, is striated, and involuntary?
cardiac muscle --> striations, involuntary

myocytes or cardiocytes are shorter, branched, and notched at ends

contain one centrally located nucleus surrounded by light-staining glycogen

intercalated discs join cardiocytes end to end
Which form of muscular tissue consists of one centrally located nucleus, relatively short fusiform cells, lacks striations, and is involuntary?
smooth muscle --> lacks striations, involuntary

visceral muscle - forms layers of digestive, respiratory, and urinary tract: propels contents through an organ, regulates diameter of blood vessels
What are the connections between one cell and another?
cell junctions

All cells (except blood and metastatic cancer cells) are anchored to each other or their matrix by intercellular junctions

resist stress and communicate with each other
Which junction is a region in which adjacent cells are bound together by fusion of the outer phospholipid layer of their plasma membranes?
tight junction --> seals of intercellular space; makes it impossible for substance to pass between cells

in epithelia, forms a zone that completely encircles each cell near its apical pole
What is a patch that holds cells together, serves to keep cells from pulling apart, and resists mechanical stress?
desmosomes (like a clothing snap)

hooklike J-shaped proteins arise from the cytoskeleton
What anchors the basal cells of epithelium to the underlying basement membrane causing epithelium to not easily peel away from underlying tissues?
hemidesmosomes
Which junction is formed by a ringlike protein called connexon, consists of 6 transmembrane proteins arranged like segments of an orange, and has surrounding water-filled pores?
gap (communicating) junction

ions, glucose, amino acids, and other solutes pass from one cell to the next
What is a cell or organ that secretes substances for use elsewhere in the body or releases them for elimination from the body?
gland --> composed of epithelial tissue in a connective tissue framework and capsule

may produce product synthesized by the gland (digestive enzymes) or products removed from tissues and modified by the gland (urine)

secretion product is useful to the body
excretion production is waste
Which glands maintain their contact with the body surface by way of a duct (epithelial tube that conveys secretion to surface)?
exocrine glands

sweat, mammary, and tear glands
Which glands lose their contact with the surface and have no ducts?
endocrine glands

hormones
secrete (hormones) directly into blood
thyroid, adrenal, and pituitary glands
Which organs have both exocrine and endocrine glands?
liver, gonads, pancreas
Which glands are found in epithelium that is predominantly nonsecretory and can be endocrine or exocrine?
unicellular glands

mucus-secreting goblet or endocrine cells of stomach and small intestine
What is the connective covering of most exocrine glands?
capsule
What are extensions of the capsule that divide the interior of the gland into compartments (lobes, which may be further divided into lobules)?
septa or trabeculae
What is the connective tissue framework of the exocrine gland that supports and organizes granular tissue?
stroma
What are cells that perform the tasks of synthesis and secretion in exocrine glands?
parenchyma --> typically cuboidal or simple columnar epithelia
Which glands produce thin, watery secretions?
serous glands

perspiration, milk, tears, digestive juices
Which glands produces the glycoprotein, mucin, which absorbs water to form a sticky secretion called mucus?
mucous glands

goblet cells: unicellular mucous glands
Which glands release whole cells, sperm, and egg cells?
cytogenic glands
What is the shape of an exocrine gland in which the duct and secretory portion have uniform diameter?
tubular
What is the shape of an exocrine gland that has secretory cells that form a dilated sac?
acinar
What is the shape of an exocrine gland that has both tubular and acinar portions?
tubloacinar
Which exocrine gland structure has an unbranched duct? branched duct?
simple - unbranched duct

compound - branched duct
How do merocrine (eccrine) glands release their secretion?
vesicles release the secretion of merocrine glands by exocytosis

tear glands, pancreas, gastric glands, and others
List examples of apocrine glands.
axillary sweat glands, mammary glands
Which gland cells accumulate a product and then the entire cell disintegrates and has a secretion mixture of cell fragments and synthesized substance?
holocrine glands

all glands of scalp, glands of eyelids
Which membrane consists of stratified squamous epithelium resting on a layer of connective tissue and is considered the largest membrane in the body?
cutaneous membrane (skin)

stratified squamous epithelium (epidermis) resting on a layer of connective tissue (dermis)
Which membrane lines passages that open to the external environment?
mucous membranes (mucosa)

absorptive, secretory, and protective functions
Which membrane is the internal membrane that consists of simple squamous epithelium resting on a layer of areolar tissue?
serous membrane (serosa)

produces serous fluid that arises from blood

covers organs and lines walls of body cavities
How can damaged tissues be repaired?
regeneration --> replacement of dead or damaged cells by the same type of cell as before; restores normal function

skin injuries and liver regenerate


fibrosis --> replacement of damaged cells with scar tissue; holds organs together, does not restore normal function

severe cuts and burns, healing of muscle injuries, scarring of lungs in tuberculosis
What is the term that describes tissue growth through cell multiplication?
hyperplasia
What is the term that describes the enlargement of preexisting cells?
hypertrophy
Which membrane lines joint cavities?
synovial membrane

connective tissue layer only, secretes synovial fluid
What is the term that describes the development of a tumor (pleoplasm)?
neoplasia

benign or malignant
composed of abnormal, nonfunctional tissue
What are undifferentiated cells that are not yet performing any specialized function but have potential to differentiate?
stem cells
What is the term that describes the process in which unspecialized tissues of embryo become specialized mature types?
differentiation

ex: mesenchyme to muscle
What is the term that describes the process of changing from one type of mature tissue to another?
metaplasia

simple cuboidal tissue of vagina before puberty changes to stratified squamous after puberty

pseudostratified columnar epithelium of bronchi of smokers to stratified squamous epithelium
Describe totipotent embryonic stem cells.
have potential to develop into any type of fully differentiated human cells

source: cells of very early embryo
Describe pluripotent embryonic stem cells.
can develop into any type of cell in the embryo

source: cells of inner cell mass of embryo
Describe multipotent adult stem cells.
bone marrow producing several blood cell types
Describe unipotent adult stem cells.
most limited plasticity; only epidermal cells produced
Describe the healing of a cut into the skin.
severed blood vessels bleed into the cut

mast cells and damaged cells release histamine

dilates blood vessels

increases blood flow to area

makes capillaries more permeable
What 3 things does blood plasma that seeps into a wound carry?
antibodies
clotting proteins
blood cells
What forms the scab that temporarily wounds and blocks infection?
blood clot

macrophages phagocytize and digest tissue debris
What is the shrinkage of a tissue through a loss in cell size or number?
atrophy

sterile atrophy --> through normal aging
disuse atrophy --> from lack of use
What is the premature, pathological death of tissue due to trauma, toxins, or infections?
necrosis
Which form of necrosis occurs when blood supply is cut?
infarction
Which form of necrosis occurs when due to insufficient blood supply?
gangrene
Which form of necrosis occurs due to a bed sore or pressure sore?
decubitis ulcer
Which form of necrosis occurs due to an anaerobic bacterial infection?
gas gangrene