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41 Cards in this Set
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Polycythemia definition |
Abnormal excess of red blood cells with increased blood viscosity |
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Two main types of polycythemia |
Polycythemia vera which is cancerous, and secondary polycythemia which is usually seen and conditions of low O2 availability |
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Sickle cell anemia definition |
Abnormal hemoglobin formed due to one incorrect substitution of a beta chain, common in blacks and Hispanics |
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Thalassemia definition |
Abnormal or absent globin chain, typical and people of Mediterranean ancestry |
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Aplastic anemia |
Affects all formed elements , rbcs wbcs and platelets. Could be due to drugs, chemicals, radiation, or disease |
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Name the three types of increased red blood cell destruction |
Aplastic anemia, thalassemia, and sickle cell anemia |
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Define anemia |
Condition in which the blood oxygen carrying capacity is too low to support normal metabolism |
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Define acute hemorrhagic anemia |
Bleeding usually due to a trauma |
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Define chronic hemorrhagic anemia |
Usually do to slow internal bleeding such as an ulcer, or bleeding hemorrhoidal vessels, or heavy menstrual cycles |
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known as the graveyard for red blood cells |
Spleen |
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What happens to hemoglobin when it is salvaged from dead erythrocytes? |
Hemoglobin is broken down into heme , globin, and iron |
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This product of hemoglobin is transported through the blood via its transport protein transferrin , and stored in the liver as hemosiderin or ferritin for later use in new red blood cells? |
Iron |
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this product of hemoglobin is degraded into bilirubin, transferred to the liver, delivered to the gallbladder, secreted into the intestine, metabolized to urobilinogen and then to stercobilin by bacteria and excreted in feces as a brown pigment |
Heme |
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This product of hemoglobin is broken down into amino acids circulated to the delivered cells where the amino acid blocks can be used to build new proteins? |
Globin |
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Where and why is erythropoietin EPO produced |
In the kidneys, and when and when O2 to delivery decreases (hypoxia) |
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Define reticulocyte |
Young red blood cell which has just expelled its nucleus |
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When does erythropoiesis begin |
When the myeloid stem cell transforms into a proerythroblast |
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What is hematopoiesis and where does it occur |
Blood cell formation and occurs in red bone marrow |
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What is a hematopoietic stem cell (aka hemocytoblast) |
Precursor of all formed elements |
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What is hemoglobin |
Main protein which transports respiratory gases. Made of red 4 heme pigment and 4 globin protein chains. Two alpha chains and 2 Beta chains |
How many heme pigments? How many globin protein chains? |
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What are the normal hemoglobin values for men and women |
Men 13 - 18 grams / 100 milliliters. Women 12 - 16 grams/100 milliliters |
(Teens) g/100mL |
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____________ contains one iron atom which combined to 1 O2 molecule |
Heme pigment |
Each hemoglobin molecule has four of these which means that each hemoglobin molecule can bind to 4 O2 molecules |
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What is an oxyhemoglobin |
A fully oxygenated hemoglobin |
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What is deoxyhemoglobin |
Hemoglobin after delivering oxygen to the cells in a body |
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Name given to hemoglobin when it is carrying carbon dioxide |
Caraminohemoglobin |
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What does co2 bind to in the blood |
It binds to amino groups of globin and not heme. Only 20% of the CO2 in the blood is carried by the hemoglobin the rest is dissolved in plasma |
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What are the normal red blood cell counts for women and men |
Women, 4.2 to 5.4 million per microliter. Men 4.7 - 6.1 million per microliter |
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name the protein that carries O2 & CO2 in the blood |
Hemoglobin |
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Name the four proteins found in plasma |
The plasma proteins are albumin, Alpha and beta globulins, gamma globulins , & fibrinogen |
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This is the most abundant plasma protein and the largest contributor to osmotic pressure. What is it and where is it made? |
Albumin |
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Describe the plasma proteins Alpha and beta globulins and where they are made |
Transport proteins for lipids, metal ions, and fat soluble vitamins. It is made in the liver |
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Name the plasma protein that has a function in immune response and tell where it is made |
Gamma globulins and they are made and plasma cells |
Hulk is healthy |
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Name the plasma protein that forms fibrin threads in the blood clots and tell where it is made |
Fibrinogen and it is made in the liver |
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What percent of plasma is water and what percent is solute |
90% water 10% solute |
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Name the six solutes found in plasma |
Electrolytes, plasma proteins, non-protein nitrogenous substances such as cellular waste, organic nutrients, respiratory gases, and hormones |
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What are thrombocytes |
Platelets |
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What are the standard percentages for the contents of blood? |
45% erythrocytes, 55% plasma, less than 1% Buffy coat |
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What is the normal pH of blood |
7.35 - 7.45 slightly alkaline |
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What is the approximate percentage of body weight made out of blood |
5 to 8% of the total body weight |
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Approximately how many liters of blood is found in males and females |
Males 5.6 liters, females 4.5 liters |
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Are you having a good day? |
Hopefully so, if not do something to fix it |
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