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41 Cards in this Set

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Polycythemia definition

Abnormal excess of red blood cells with increased blood viscosity

Two main types of polycythemia

Polycythemia vera which is cancerous, and secondary polycythemia which is usually seen and conditions of low O2 availability

Sickle cell anemia definition

Abnormal hemoglobin formed due to one incorrect substitution of a beta chain, common in blacks and Hispanics

Thalassemia definition

Abnormal or absent globin chain, typical and people of Mediterranean ancestry

Aplastic anemia

Affects all formed elements , rbcs wbcs and platelets. Could be due to drugs, chemicals, radiation, or disease

Name the three types of increased red blood cell destruction

Aplastic anemia, thalassemia, and sickle cell anemia

Define anemia

Condition in which the blood oxygen carrying capacity is too low to support normal metabolism

Define acute hemorrhagic anemia

Bleeding usually due to a trauma

Define chronic hemorrhagic anemia

Usually do to slow internal bleeding such as an ulcer, or bleeding hemorrhoidal vessels, or heavy menstrual cycles

known as the graveyard for red blood cells

Spleen

What happens to hemoglobin when it is salvaged from dead erythrocytes?

Hemoglobin is broken down into heme , globin, and iron

This product of hemoglobin is transported through the blood via its transport protein transferrin , and stored in the liver as hemosiderin or ferritin for later use in new red blood cells?

Iron

this product of hemoglobin is degraded into bilirubin, transferred to the liver, delivered to the gallbladder, secreted into the intestine, metabolized to urobilinogen and then to stercobilin by bacteria and excreted in feces as a brown pigment

Heme

This product of hemoglobin is broken down into amino acids circulated to the delivered cells where the amino acid blocks can be used to build new proteins?

Globin

Where and why is erythropoietin EPO produced

In the kidneys, and when and when O2 to delivery decreases (hypoxia)

Define reticulocyte

Young red blood cell which has just expelled its nucleus

When does erythropoiesis begin

When the myeloid stem cell transforms into a proerythroblast

What is hematopoiesis and where does it occur

Blood cell formation and occurs in red bone marrow

What is a hematopoietic stem cell (aka hemocytoblast)

Precursor of all formed elements

What is hemoglobin

Main protein which transports respiratory gases. Made of red 4 heme pigment and 4 globin protein chains. Two alpha chains and 2 Beta chains

How many heme pigments? How many globin protein chains?

What are the normal hemoglobin values for men and women

Men 13 - 18 grams / 100 milliliters. Women 12 - 16 grams/100 milliliters

(Teens) g/100mL

____________ contains one iron atom which combined to 1 O2 molecule

Heme pigment

Each hemoglobin molecule has four of these which means that each hemoglobin molecule can bind to 4 O2 molecules

What is an oxyhemoglobin

A fully oxygenated hemoglobin

What is deoxyhemoglobin

Hemoglobin after delivering oxygen to the cells in a body


Name given to hemoglobin when it is carrying carbon dioxide

Caraminohemoglobin

What does co2 bind to in the blood

It binds to amino groups of globin and not heme. Only 20% of the CO2 in the blood is carried by the hemoglobin the rest is dissolved in plasma

What are the normal red blood cell counts for women and men

Women, 4.2 to 5.4 million per microliter. Men 4.7 - 6.1 million per microliter

name the protein that carries O2 & CO2 in the blood

Hemoglobin

Name the four proteins found in plasma

The plasma proteins are albumin, Alpha and beta globulins, gamma globulins , & fibrinogen

This is the most abundant plasma protein and the largest contributor to osmotic pressure. What is it and where is it made?

Albumin

Describe the plasma proteins Alpha and beta globulins and where they are made

Transport proteins for lipids, metal ions, and fat soluble vitamins. It is made in the liver

Name the plasma protein that has a function in immune response and tell where it is made

Gamma globulins and they are made and plasma cells

Hulk is healthy

Name the plasma protein that forms fibrin threads in the blood clots and tell where it is made

Fibrinogen and it is made in the liver

What percent of plasma is water and what percent is solute

90% water 10% solute

Name the six solutes found in plasma

Electrolytes, plasma proteins, non-protein nitrogenous substances such as cellular waste, organic nutrients, respiratory gases, and hormones

What are thrombocytes

Platelets

What are the standard percentages for the contents of blood?

45% erythrocytes, 55% plasma, less than 1% Buffy coat

What is the normal pH of blood

7.35 - 7.45 slightly alkaline

What is the approximate percentage of body weight made out of blood

5 to 8% of the total body weight

Approximately how many liters of blood is found in males and females

Males 5.6 liters, females 4.5 liters

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