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216 Cards in this Set

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Attach:

caudal: transverse processes of vertebrae
crainal: spinous processes of vertebrae

(answer is a large group of muscles)

what are their functions? (4)
transversospinae muscles

1. intervertebral extension
2. " abduction
3. rotation
4. semispinalis capitis extends the head
span 4 to 6 vertebrae from caudal (transverse process) to spinous process

one component attaches to back of skull?
semispinalis

(cervicus attaches to vertebrae)

semispinalis capitis attaches to head
span 2 to 4 vertebrae from caudal to cranial attachment
multifidis
transverse process of one vertebrae to spinous process/lamina of the adjacent (next one above) vertebra?
SHORT rotators
transverse process of a vertebra to spinous process/lamina of the second vertebra above
LONG rotators
attach to spinous process of upper thoracic and lower cervical vertebrae, cranial attachments to trans processes of cervical vert and skull
splenius cervicus

splenius capitis (attaches to head)
functions of splenius cervicis/capitis
-intervert. joint extension (ext of head by capitis)
-abduction
-abduction of head by splenius capitis
-intervert. rotation to side where muscle is contracting
-rotation of head by splen capitis
attach at axis, atlas, occipital bone (muscle group)
innervated by first cervical nerve--maintain head in upright position
Muscles of suboccipital Triangle:
rectus capitis posterior major
obliquus capitis inferior ("inferior oblique"
obliquus capitis superior
attach: spine of axis to occipital bone

function?
rectus capitis posterior major

extends the head
spine of the axis to transverse process of the atlas

function?
obliquus capitis inferior

rotates head to side on which muscle is contracting
from trans process of atlas and attaches to occipital bone

function?
obliquus capitis superior

extend head
attach to anterior aspects of cervical vertebral bodies, transverse processes of vertebrae and occipital bone

flex head and heck when contracting bilaterally; when contracting on one side they assist in abduction of head/neck

innervated?
longus colli and longus capitis (whiplash muscles!!)

anterior muscles
innervated by VENTRAL rami of spinal nerves
cranial attachment to trans process of 4-6 cervical vertebrae
scalene muscles (anterior, middle, posterior)
caudal atach: first rib
cranial: trans process C4-6
anterior scalene
caudal attach: 2nd rib
cranial: trans process C4-6

(2 muscles have thiese attachments)

muscle function?
posterior and middle scalenes

flex neck when acting bilaterally, and laterally flex (abduct) and rotate neck and head when acting on one side only

accessory respiratory: cranial attachments fixed, elevates ribs

innervated by *ventral* rami of cervical spinal nerves
Scalenus Anticus Syndrome
compression of brachial plexus and subclavian artery (these are b/t middle and anterior scalenes) due to increased muscle tone. symptoms: tingling in head, muscle weakness, loss of pulse in periph arteries of limb
How do muscle fibers shorten?
Sliding filament mechanism.

In presence of Calcium (cardiac), action potentials spread from motor neuron to motor end plate.

Depolarization of membranes initiates cross-bridge cycling, actin and myosin slide past one another allowing the sarcomere to shorten. (skeletal)

look up in phys?
Skeletal Muscle:
1. appearance?
2. shape/position of nucleus
3. how is it innervated
4. location
1. striated b/c of organized myosin/actin filaments.
long, multinucleated cells
2. nuclei are oval, located at periphery
3. innervated by alpha motor neurons from CNS (voluntary muscle)
4. limbs, abs, etc.
Smooth Muscle:
1. appearance
2. shape/position of nucleus
3. innervated?
4. location?
1. appears smooth
long, spindle-shaped cells w/ one oval nucleus
2. nucleus in middle
3. Innervated by AUTONOMIC NS. (as well as hormones, local stretch receptors)
4. walls of hollow viscera, walls and ducts of blood vessels, hair follicle (goosebumps)

slowest to contract, longest to fatigue
Cardiac Muscle
1. cross-striation (like skeletal!!) look striated!!!
but not arranged all parallel, but connected end to end w/ intercalc. discs.

2. One oval shaped nucleus in middle of cell

3. Innervated by SYMP and PARASYMP nerves (autonomic)

4. Located in the heart! *has richest blood supply

5. Less powerful than skel muscle but more resistant to fatigue
Which type of muscle fiber fatigues most easily?
Skeletal
What controls the degree of shortening in skeletal muscles?
*ARRANGEMENT OF MUSCLE FIBERS* (parallel vs. penniform!!)

Parallel can shorten more! (therefore greater ROM)
What is atrophy?

hypertrophy?
muscle fibers DECREASE in size

muscle fibers iNCREASE in size
how does muscle attach to bone? what is meant by harnessing?
epimysium, perimysium and endomysium all come together to form tendon, which then attaches to periosteum of bone.

Force goes along this pathway to the bone.
Parallel v. penniform muscle fibers:

ROM?
Force?
Parallel has greater ROM, less force

Penniform has greater FORCE (more fibers in cross sectional area), less ROM
Type 1 muscle fiber
1. fast/slow?
2. color? why?
3. resistant to fatigue or no?
4. mitochondria?
5. what kind of metabolism/energy?
6. found where?
1. Slow-twitch
2. red, lots of myoglobin
3. resistant to fatigue
4. lots of mitoch
5. OXIDATIVE METABOLISM (energy from fats/acids)
6. Found in INTRINSIC BACK MUSCLES nad soleus
Type 2 Fibers
1. fast/slow?
2. color? why?
3. mitoch?
4. resistant to fatigue/no?
5. energy source?
6. example?
1. Fast-Twitch Fibers
2. White b/c of no myoglobin
3. few mitochondria
4. fatigue easily
5. energy from GLYCOLISIS--produces lactic acid
6. example: gastrocnemius
Epimysium, Perimysium, Endomysium

what are these made of?
Epimysium is the connective tissue investment of the ENTIRE muscle. Epimysium=fascia!

Perimysium surrounds muscle fiber bundles called FASCICLES.

Endomysium=connective tissue investment of INDIVIDUAL FIBERS

made of COLLAGEN (these are areolar connective tissues)

Conn. tissue makes up 15% of muscle!
Myotendinous Junction
the point where endomysium and perimysium become continuous with one another beyond muscle fibers. (this is where force is transferred from muscle to tendon)
Connective Tissue (muscle) Functions?

there are 5
1. Skeletal framework
2. Determines how much deformability/stretching/elasticity
3. Path for nerves, blood vessels, lymph
4. ATTACHMENT of muscles to bone and TRASMISSION Of force from muscle to bone
5. "Sink" for ions
List types of Nerve Fibers
1. Somatic Motor Nerve
2. Proprioceptive Motor/Sensory
3. Sympathetic (autonomic) nerve fibers
4. General sensory fibers
Function of Somatic Motor Nerve Fiber to muscle fibers?
-axons of alpha motor neurons that end at neuromusc. junction

Myelinated axons=fastest fibers in body, bring "gross" contraction of muscle
Sympathetic/autonomic nerve fibers (to muscle) function
small, non-myelinated. Innervate smooth muscle of BLOOD VESSELS in a muscle!
General sensory Nerve Fibers (to muscle) function?
Convey pain, sensations from free nerve terminals on CONN. TISSUE SHEATHS of muscle
Motor Unit definition?

What factors determine size of motor units?
Alpha motor neuron and the muscle fibers it innervates

Factors:
1. muscle function
2. amount of force needed (as this increases, body will recruit more fibers via MORE ALPHA NEURONS!!)
3. CNS selective control
4. force diffuses thruout muscles
Isometric contraction

example?
generates Force
(xb cycling ALWAYS generates force)

INCREASED TENSION, BUT LENGTH STAYS SAME

example: maintain body in erect posture
Isotonic Contraction?
Tension increases, LENGTH changes.

1. concentric
2. eccentric
Concentric (isotonic) contraction
Muscle fibers SHORTEN.

i.e. use biceps brachii to flex at elbow
(pull>resistance)
Eccentric Contraction
gradual elongation of muscle as tension increases

sitting down from standing, lowering dumbbell from flexed to extended
pull<resistance
Prime Mover

Antagonist
muscle consistently active in initiating and maintaining a movement

antagonist: muscles that wholly oppose the movement or initiate/maintain the *opposite movement

i.e. biceps brachii in elbow flexion
Fixator
When prime mover and antagonist contract together.

this STABILIZES joint, creates stable base on which other muscles may act

**any given muscle can be fixator, prime mover, OR antagonist, depending on the mvmt!**`
What happens when a muscle loses sensory innervation?

Effects of complete denervation of muscle? Reversible?
Poor proprioception and coordination. Loss of muscle tone at rest.

Complete denervation: Muscle fibers DEGENERATE.
Gradually decrease in size, replaced by conn tissue

**largely reversible for at least 12 months (electrical stim and massage of muscle can slow degeneration process). If w/in 12 months muscle will recover most of former strength
Major Function of Each:
1. Cell
2. Tissue
3. Organ
4. Organ System
1. Basic unit capable of functioning independently; basic building block of the body!

2. Tissue: specialized in common direction to perform specific function (cover body surfaces, line cavities, connect things to one another, muscle=movement, nervous tissue--respond to stimuli)

3. Organ: 2 or more tissue types for a collective function

4. Organ System: homeostasis
Function of each:
1. Cell membrane
2. Nucleus
3. Mitochondria
4. Lysosomes
5. Endoplasmic Reticulum-Rough
6. Smooth ER
7. Golgi complex
8. Microtubules
9. Centrioles
1. Cell Membrane: passive/active transport across, receptors that influence cell function
Modifications: microvilli, cell junctions, cilia, receptor molecules, phagocytosis

2. Nucleus: genetic material, DNA, makes RNA, which is necessary for protein synthesis

3. Mitochondria: ENERGY/ATP

4. Lysosomes: full of enzymes--BREAK DOWN LARGE MOLECULES

5. RER: HAS RIBOSOMES AND MAKES PROTEINS

6. SER: no ribosomes, synthesizes FAT, drugs/alcohol/toxins

7. Golgi: STORES proteins!

8. Microtubules: form skeleton of neurons and other cells (filament-like cells) i.e. actin/myosin parts of muscle cells

9. Centrioles: distribute chromosomes to daughter cells during meiosis and mitosis (mature cells DO NOT have them and can't divide)
In what type of cell would you expect to find lysosomes?

RER?

Lots of SER?

lots of Golgi?

lots of microtubules?

lots of centrioles?
ots of lysosomes in MACROPHAGES/anything that is going to break down large molecules

Lots of RER in protein synthesizing cells

Lots of SER in liver cells (break down toxins)

lots of golgi in cells that SECRETE proteins, i.e. thyroid gland, pancreatic cells

lots of microtubules in muscle cells (myofilaments)

centrioles in mitotic/meiotic cells? (look up) embryonic/stem cells
What are junctional complexes (cellular level)?
between 2 cells: tight junction (prevents material from passing b/t cells)
gap junctions (cell to cell communication)

adhering junctions
Microvilli
modified plasma membrane

free surface FOLDED, looks like projections. i.e. small intestine
Cilia
hair-like PROCESSES that extend from surface, NOT MODIFIED MEMBRANE LIKE MICROVILLI!

made of microtubules

"move/beat"

found in respiatory tract, repro tracts
phagocytosis/pinocytosis
pino=process where small drops of fluid incorporated into cell

phago=duh. envelops. once in cell=phagocytitic vesicle, can be attached by other organelles

i.e. white blood cells and macrophages!! must digest toxins
Distinguishing characteristics of epithelia?
"sheets" of cells (either single layer or multi)

-adjacent cells w/ little/no intercellular substance

1. basement membrane
2. avascular but innervated (nerves don't pierce or travel thru epithelia, but some epi have receptor cells)
**no blood=receive nutrients from diffusion from caps in underlying conn tiss
3. Specialized Junctions--cell communication and adherence
4. Mitosis: i.e. skin cells sloughed up and constantly remade
Basal Lamina/Basement Membrane of epithelial cells-what is it made of? what is it's function?
made of thin layer of protein fibers and complex carbs (produced by epithelial cells OR conn tissue)

anchors cells to underlying tissue
Simple Squamous Epithelium

Layers/Cell Shape?
Function?
Location?
1 Layer, flat cells

function: absorption/diffusion
location: lining of heart, blood and lymph vessels, thoracic and abdominal cavities, air sacs of lung
Stratified Squam Epithelium
multilayered, flat cells

function: PROTECTION

location: outer layer of skin, lining oral cavity, esophagus, vagina
(places it's sloughed off=many layers ok!)

BASAL CELLS DIVIDE to replace lost cells!
Simple Columnar Epithelium with microvilli

function? location?
one layer, column cells

function? ABSORPTION
location? SI lining
Pseudostratified Columnar Epithelium, ciliated

function?
Appears to be stratified but really just one layer, columnar cells

function: mvmt of stuff OUT of body
location: upper respiratory tract lining
Transitional Epithelium

location/function
location: bladder
function?: accommodate distension of bladder
simple cuboidal epithelium

function/location?
secretion/absorption

location: lines kidney tubules/ducts, surface of ovary, inner surface of cornea and eye lens
Stratified Cuboidal Epithelium
Function?
Protection!!

Location: ducts of adult sweat glands
Simple Columnar Epithelium
absorption/secretion

location: stomach and SI lining
Stratified Columnar Epithelium function/location?
protection/secretion

location: part of male urethra (only location)
What is a gland? (tissue type, examples)

How do multicellular glands develop?
Made of epithelial tissue specialized for *secretion*

may be single celled or multi

Multi glands: epi tissue in a region has proliferated and invaginated INTO underlying tissue to form a gland made of many cells
examples: liver, pancreas, salivary, endocrine
Endocrine vs. exocrine glands?
Endocrine releases substance INTO blood stream to be carried around and THEN hit its target cell/tissue (pituitary, thyroid, adrenal, testes/ovaries, ENDOCRINE portion of pancreas that produces insulin)

Exocrine releases substance INTO **duct, then they empty onto surface of target epithelial tissue (i.e. sweat, salivary, subaceous glands, exocrine components of pancreas/liver)
What cell types are found in connective tissue? (2 types w/ 3 subtypes. Name 2 major ones and describe)
1. Fixed Cells: STAY WITHIN confines of CONN TISSUE itself. Do not move b/t conn tissue and blood stream. They can move around, just w/in these confines.

2. Wandering Cells: move in and out of bloodstream as well as w/in conn tissue itself (i.e. deliver large nos of specific cell types to region where needed, i.e. inflammatory response)
Types of Fixed Cells (in Connective Tissue)

3 types
1. Fibroblasts: synthesize and secrete ground substance and fibrous elements that form the ECM of conn tissue (means "fiber-forming cell")

2. Fat Cells: COLLEct fat droplets in cytoplasm. The lipid molecules form a single large droplet/vacuole--puts nucleus and cytoplasm to periphery
function: energy storage, h2o storage, insulation, protection

3. Macrophages: phagocytosis, immune response, scar formation
2. Fat Cells
3. Macrophages
Types of Wandering Cells (in Conn Tissue)
1. Mast Cells: common near blood vessels, secrete *heparin and *histamine

2. Plasma cells: mostly found in conn tiss of LI and SI
**produce antibodies!!* (immune)

3. Blood Cells: RBCs stay in blood stream; other cells (WBCs, monocytes, lymphocytes, etc) move b/t blood and conn tiss--inflammatory/immune response
Histamine =what does it do?

(released by mast cells of conn tissue)
VASODILATOR

Increases permeability of capillary beds, allowing fluid to leak into Extracellular space (swelling)
3 Fiber Types found in Connective Tissue?
Collagen, Elastin, Reticular Fibers
Collagen Fibers function?
-made by fibro, osteo, and chondroblasts

consist of fibrils/microfibrillar units
-STRENGTH OF STEEL
-straight or wavy. Can be straightened by pulling, but LITTLE/NO stretching!!!
-tendons, ligaments, joint capsules
Elastic Fibers Function?
made of elastin, CAN be stretched, become less resilient w/ age

many in external ear

made by fibro and chondroblasts
Reticular Fibers

made of?
function?
made of special type of collagen

arranged in networks and iNELASTIC

form supptortive network for cells of many structures (like lymph nodes and blood forming organs)
Biosynthesis of Collagen Fibers:

what components of cell are involved?
1. On RER: polypeptide chains are MADE
2. Chains group together to make triple helices=procollagen molecules
3. Procoll mols go to Golgi
4. On Golgi--modified into COLLAGEN molecules. These go to cell exterior to form part of ECM
5. Then aggregate to form collagen fibers
Collagen biosynthesis

1. type of collagen produced depends on ______?
2. What determines how fibers line up?

What is the diff b/t collagen found in bone and collagen found in cartilage
Type produced depends on HOW chains aggregate

2. Fibers line up PARALLEL to FORCES to which developing tissue is exposed!

Bone is type 1 collagen
forms bc of arrangement of alpha chains AND in response to stress!

Type 2: ONLY in cartilage (3 alpha one chains)
What are the components of ground substance? are they living?
NON-LIVING material in which cells and fibers are embedded

made up of Carbs and Protein molecules called glycosaminoglycans + h2o, sugar, calcium salts
what is responsible for development of primary curvatures of spine?

2.secondary curves?
different height b/t front/back of vertebral bodies

2. intervertebral discs
Lordosis

-which curvatures?
-causes?
"sway back"

secondary curvature

cause: poor posture, pregnancy, weak abs/tight low back
Kyphosis

-which curves? causes?
primary curves

"hunch back"
-poor posture, bone deformities, osteoperosis/age, abnormal intervertebral discs
Scoliosis

-curves? causes?
curve in coronal plane

cause: unknown, congenital, unilateral paralysis of intrinsic back muscles, one leg shorter than the other
Anterior Longitudinal Ligament

location? function?
anterior of vertebral body

limits hyperextension, reinforces intervert. discs
Posterior Longitudinal Ligament

location? function?
located in vertebral canal on posterior side of vertebral body

does NOT reinforce discs
Ligamentum Flavum
ligamentum flavum located posterior side of vertebral canal (side of the hole nearest spinous process)

slows flexion of spinal column, help erection of spine (i.e. after bent over)--VERY ELASTIC!
Major components of an intervertebral disc? (3)

What are their functions?
anulus Fibrosus: dense fibrous tissue attached to periphery of bodies of adj. vertebrae

thick anterior (thin posterior--hence slipped discs)

Nucleus Pulposis: "jelly donut," 80% h2o, center of disc surr. by anulus, changes shape 4 mvmts BUT incompressible

3. hyaline cartilage: covers articulating surfaces of vert. bodies; function--GROWTH of discs and verte. bodies, pathway for nutrients to discs from marrow cavity of vertebrae
In what region is herniation of a disc likely to occur? Why?

What is sciatica?
bulging thru the weak part of a "tire" (anulus) is called "herniation of the nucleus pulposus"
-usually posteroLATERAL b/c column is usually FLEXED when stresses upon it

most frequently LUMBAR, esp b/t L4 L5 or L5 and sacrum
, sometimes cervical

Sciatica: on side of herniation, spinal rootlets are compressed, causing scoliotic curve concavity on side of herniation (b/c muscles on other side are still contracting to pull you up, but no contrxn on herniated side)
Usually compress roots L5/Sacral, pain felt down back and lateral sides of legs radiating to foot

Sciatica:
How does sagital orientation of lumbar synovial joints affect rotation/flexion and extension?
these mvmts occur mainly at lumbar region b/c of thoracic spine limitations (rib cage, int discs). can "camouflage" their limited-ness by mvmt at hip joints

Cervical: flexion/extension/lateral bending are SUMS of mvmts at atlanto-occ, lateral atlanto-axial, and other cerv. joints.
atlanto-ax joint: rotation of head
what movements occur at occipital bone and atlas? what muscles involved?

axis and atlas? what muscles?
flexion (chin to chest),
muscles: rectus capitis, longus capitis, SCM
**extension
muscles: rectus, superior oblique, splenius cap, longissimus cap, trap

atlas and axis: rotation of head (chin level w/ shoulders)
-inferior oblique, SCM, semispinalis
how might scoliotic curve develop in someone w/ one leg shorter than other?
-tone on one side pulls spine to that side aaand slightly rotates it, leading to rib deformity, respiratory problems, vertebral deformity, and compensatory cervical curve
location and function of longus capitis and colli muscles?

what can happen if they're hyperext?
attachments: anterior cervical vertebral bodies, transverse processes of vertebrae, to occipital bone

function: head flex/ext when bilateral contrxn

unilateral: abduction/lateral flexion to either side

trauma=whiplash
position/function of:

anterior scalene

middle scalene

posterior scalene
anterior: 1st rib to transverse processes C4-C6

posterior and middle scalenes: 2nd rib to transverse C4-6

function: blex neck (bilateral)
unilateral--abduct, rotate head
accessory breathing muscles
literal meanings of:
pia mater
aracnoid
dura mater
cauda equina
delicate mother
spider-like
tough mother
horse tail
arachnoid trabeculae
branching strands of arachnoid (on its inner surface) that pass THRU subarachnoid space and attach to Pia Mater
composition:
dura mater, arachnoid, pia

diff b/t meningeal covers in cranial cavity vs. vertebral canal? why?
dura=collagen

arachnoid=loose conn tissue

pia=loose conn tiss full of blood vessels

cranial cavity=no epidural space
verte canal: dural sac extends to sacrum, epidural space full of blood vessels--space allows mvmt of brain w/o affecting spinal cord
What is CSF? composition? where found? function?
CSF=plasma-like fluid filling the SUBARACH space

function=support, buoyancy (spinal cord cannot hold up brain/itself
composition of grey matter?
cell bodies of neurons, their dendrites, proximal parts of axons
comp of dorsal horn
incoming nerve fibers from ganglia
dorsal roots composition?
exclusively of sensory nerve fibers
ventral horn composition?

ventral roots comp?
large somatic motor neurons

roots: AXONS of these MOTOR neurons along w/ axons from AUTO NS
why gray matter enlarged at some spots?
cervail/vertical bc of up/low limbs

thoracic have small vent horn BUT have a lateral horn w/ autonomic nerve cell bodies
white matter composition
myelinated nerve fibers that run up /down cord to/from CNS
dorsal ramus contains?
SENSORY AND MOTOR neurons going to back muscles, trunk, neck
Ventral ramus contains?
SENSORY AND MOTOR neurons going to the rest of the body
what is a dermatome? clinical corre?
area of skin innervated by specific spinal nerve

clinical: Shingles! viruses transported VIA axons. when immune system is weak, they travel back out to the skin and produce rash
what segmental level of spine innervates umbilicus?
T10
layers needle goes thru to get to subarachnoid space
skin and subcutaneous tissue
ligamentum flavum
epidural space
dura mater
subdural space
arachnoid
subarachnoid space
What type of tissue makes up epidermis?

Dermis?
epi=stratified squamous epithelium

dermis: loose regular connective tissue that contains ALL cell and fiber types of connective tissue!!!
What are characteristics of stratum basale and stratum corneum?
stratum basale=alive, mitotic, DEEPEST layer of epidermis.
function: maintenance of epithelial component of skin (to compensate for cells being sloughed off)

stratum corneum: most superficial layer, DEAD, keratinized cells
function: resist passage of fluids/substances/friction. thickness varies thruout body, cells constantly being sloughed
How does skin become keratinized? Where?

Describe someone w/ hyperkeratosis.
Skin becomes keratinized on the epidermis. It is the process of skin becoming scale-like, dead

Keratohyaline made by cells near the stratum basale, interacts w/ cells and transforms them into dead ones. End product is barrier, waterproofing, protection, defense from infection

hyperkeratin; orange!
Function of melanocytes?

langerhans cells?

where are they located?
make melainin (pigment) protects deeper layers from UV rays

-langerhans=MACROPHAGES that activate immune system, another line of defense
What major cell/fiber types are found in dermis?
Describe position/location of papillary and reticular layers of dermis (relative to epiderm)
**ALL**

part of dermis RIGHT next to dermis=capillaries and nerve endings=**papillary layer**

Reticular Layer: depper portion, DENSELY interwoven tissue, more collagen and elastic, 75% of epid. thickness
What are dermal papillae?
What structures are within? Or associated w/?
papillae: nipple-like projections from papillary layer of dermis that fit into indentations on the surface of epidermis==anchored TOGETHER
-EPi obtains nutrients via diffusion from vessels in pap layer
hair follicle and subaceous glands and sweat glands are all derived from what layer of skin?
*8basal layer of epidermis
what are tension lines of skin?

how would you make an incision on abdominal wall? at wrist?
collagen/elastic fibers oriented parallel to lines along which skin is folded during mvmt

lines are determined by sticking sharp rounded obj into cadaver that leaves a slit-wound in fibers' direction

CUTS SHOULD BE MADE IN THE DIRECTION OF THESE LINES, skin gapes less widely, less scar tissue
individuals' hair growth is dependent on what?
high mitotic activity of epidermis basal layer

chemotherapy destroy most rapidly dividing cells in body (like epi cells, hence hair loss)
Function of sweat glands and arrector pili muscles (muscles that cause hair to stand on end) are modulated by __________ component of nervous system?
*sympathetic (autonomic)

regulates temperature
ppl w/ spinal cord injury in region of symp nervous system can't sweat--must use spray bottle, AC, be careful, etc.
how do decubitus ulcers develop?


how are layers of skin affected by 1st, 2nd, 3rd degree burns?
ulcers/bedsores: area of skin is close to bone and undergoes constant pressure (i.e. being bedridden). this compresses blood vessels, leads to tissue/cell death

1st: epidermis damaged not destroyed; redness, pain. i.e. sunburn

2nd: destroy epidermis, some damage to dermis
--blisters, moist surface due to plasma loss, nerve endings still in tact!! may be scarring, need treatment

3rd degree: destroy epi, dermis, AND underlying tissue
-nerve endings destroyed, skin can't regenerate, white/charred appearance, loss of body fluids, surgery ALWAYS necessary
Chondroucoprotein

Lacunae

Perichondrium

(define)
glycoprotein that makes up the ground substance of ECM of cartilage. Collagen fibers are embedded in this substance.

Perichondrium: dense layer of connective tissue investing cartilage

Lacunae: circular compartments of cartilage's ECM--inside are chondrocytes ("swiss cheese holes")
How do cartilage cells get nutrients, O2, etc?
diffusion thru ground substance from vessels in tissue surrounding cartilage
Characteristics of 3 main types of cartilage? Location?
1. Hyaline: LOTS of ground subst, collagen fibers
**embryonic skel, articular cartilage, larynx, trachea, costals

2. Elastic: yellow, fibrous, ELASTIC fibers in ground subst
**ear, auditory tube

3. Fibrocartilage: white, "regular" collagen, small ground subst
**intervert discs, pubic symphysis
Cartilage growth:
1. Interstitial

2. Appositional
1. Inter: from within. Each cart. cell in lacuna secretes large amts of new matrix material (chondroblast). Cartilage expands.

2. Appo: deposit ECM around surface. Cells in layer of perichondrium synthesize extracellular Matrix of cartilage, size increases.
Chondroblast vs. chondrocyte function?

what types of cell organelles in each?
Blast=produce the MATRIX of cartilage that leads to GROWTH of cartilage
(lots of RER=makes proteins)?

CYTE=maintain ECM of cartilage
lots of RER? rigid? umm...

** look this up!!:)
literal meanings of:
lacuna
perichondrium
chondrocyte
chondroblast
interstitial
appositional
lacuna=hole/pit

perichondrium="around cartilage"

chondrocyte="cartilage cell"

chondroblast="cartilage sprout/germ/bud"

interstitial: "between"
appositional: "united/applied"
What are the joints of the shoulder girdle? (2)

what movements occur at each?
what ligaments assoc w/ each?

Are the joints uni, bi, multiaxial?) Why?
Sternoclavicular Joint: elevation/depression, protraction/retraction, up/down rotation of glenoid fossa

ligaments: sternoclavicular, interclavicular, costoclavicular

Acromioclavicular Joint: "gliding" movements

Ligaments: coracoclavicular (conoid and trapezoid), coracoacromial lig
Multiaxial

Spherical Nature of articular surfaces
and
Fibrous discs b/t surfaces
Location and Function of:
Sternoclavicular Ligaments (2)
Anterior and Posterior ligaments

Link to axial skeleton (anterior b/t sternum and clavical in the front, posterior link b/t sternum and clav in the back)
thickening of joint capsule itself (intra-capsular ligs), limit movement in all directions
Location and function of costoclavicular ligamentq
between 1st rib and clavicle (bilaterally)

LImits unwanted superior mvmt of clavicle, fulcrum for some clavicle mvmt
location and function of interclavicular lig
between *sternal* ends of 2 clavicles, across the sternal notch

limits unwanted/excessive depression of shoulder girdle
location/function of coracoclavicular ligaments (2-names?)
1. Conoid Ligament (more medial)
2. Trapezoid Lig (more lateral)

Location: strong union b/t scapula and clavicle--connect clavicle and coracoid process!

limit unwanted mvmt b/t scapula and clavicle

**these are usually torn during shoulder separation, *but* stronger than bone itself--clav will fracture before they're broken
location/function of coracoacromial ligament
b/t coracoid and acromion processes of the scapula (2 processes of SAME BONE): forms roof over head of humerus, prevents unwanted superior mvmts of humeral head, separates supraspinatus muscle from deltoid muscle
What is the glenoid Labrum? functions?
structure that "deepens" glenoid fossa

fibrocartilaginous ring that attaches at circumference of glenoid fossa

maintains uniform film of synovial fluid across joint surface (and deepens fossa)
What is meant by scapulohumeral rhythm?
movements at glenohumeral joint occur in concert w/ mvmts of shoulder girdle!! If one doesn't work, neither does other, etc.
Movements at glenohumeral joint? (flex, extend? etc)
flexion extension, ab/adduction, rotation, and any combo
Scapulohumeral Rhythm:
What shoulder girdle mvmts accompany shoulder joint ab/adduction? What muscles involved?
Shoulder joint ab/adduction=upward/downward rotation of glenoid fossa

muscles: (ab)=upper trap, serratus anterior, lower trap

ad: levator scapulae, rhomboids, lats, pecs
What would happen to full range of shoulder joint flexion (abduction) if muscles of shoulder girdle are paralyzed?

What position will shoulder girdle assume w/ paralysis of girdle muscles?
If shoulder girdle muscles are paralyzed, shoulder joint flexion/extension probably will not happen at all or very minimally.

Shoulder girdle muscles paralyzed (i.e. serratus ant)=downward rotation of the glenoid fossa b/c of weight of arm itself, posterior mvmt of scapula ("winging") b/c normally muscles keep scapula tight against body wall.
Shoulder separation

vs.

Shoulder dislocation
1. acromioclavicular joint: usually trauma to joint capsule, broken clavicle and/or torn ligaments (conoid/trapezoid ligs)

2. Dislocation: displacement of head of humerus from glenoid fossa, usually anterior/inferiorly. May stretch/tear joint capsule.
Rotator cuff muscles: supraspinatus, infraspinatus, teres minor, subscapularis ("SITS")
What is a bursa?
Where are they found?
Show/describe in words location of
1. subacromial bursa
2. subdeltoid bursa
Bursa=flattened sac of connective tissue lined by synovial membrane w/ small amt of synovial fluid

found b/t structures in close contact w/ each other (to prevent friction)

subacromial: b/t acromion process of scapula and supraspinatus tendon (which is on top of the joint capsule, superior to humerus

subdeltoid bursa: b/t delt and humeral head
What muscles form rotator cuff?
attachments?
functions:
1. mvmts of shoulder joint?
2. maintaining integrity of shoulder joint?
SITS: supraspinatus, infraspinatus, teres minor, subscapularus

proximal attachment: dorsal/costal surfaces of scapula
distal: blend w/ parts of shoulder joint capsule

as tendons reach shoulder joint capsule, they blend w/ it and form a "cuff" around the joint on all sides except inferior

1. Movements: ??? Look up in Book***
2. Integrity: maintain head of humerus in glenoid fossa, prevent dislocation
Muscle Attachment
Function
What happens if paralyzed

TRAPEZIUS
proximal attachment at skull and vertebral spine, distal attachment scapular

when distal attach fixed, moves head and neck @ atlanto-occipital joint

proximal attach fixed: maintain shoulder girdle in approp position, move/stabilize girdle during abduction and flexion of arm

Functions:
-shoulder girdle elevation
- " " retraction
-upward rotation of glenoid fossa

Paralysis:
-exaggerated girdle depression
-some weakness in elevation
-abduct/flex arm diminished b/c weakness in ability to rotate fossa
Attachments?
Function?
Paralysis effects?

RHOMBOID1
attachment: ?? * look up

functions:
-shoulder girdle elevation
-downward rotation of glenoid fossa (adduction/ext of arm)
shoulder girdle retraction

paralysis:
scapula tends to protract b/c of free limb
-decreased ability to extend/adduct arm
LEVATOR SCAPULAE

attach?
function?
paralysis effects?
attach?

functions:
shoulder girdle elevation
shoulder girdle protraction

paralysis:
other muscles can assume almost completely its function
attach/function/paralysis effects?

Pectoralis Minor
function:
downward rotation of glenoid fossa
-protract shoulder girdle
-depress shoulder girdle

paralysis: affect one's ability to downward rotate glen fossa, and component of ext/adduction of arm (scapulohum rhythm)
function/paralysis effects?

Serratus Anterior
**like trap!**
-upward rotation of glenoid fossa during abduction/flexion of arm
-approp position of girdle on chest wall
-STRONG protractor
-shoulder girdle depression

Weakness/Paralysis:
-"winging" of scapula
-impossible to do pushup if bilaterally paralyzed
-can't abduct/flex shoulder joint (b/c can't upwardly rotate glen fossa)
-if both serr and trap are paralyzed, can't abduct/flex arm, overall mvmt/position of girdle=awful
Subclavius
-depressing clavicle
-stabilize clavicle
what 4 muscles extend from trunk to scapula/ and clavicle and produce mvmts of shoulder girdle?
trapezius
serratus anterior
rhomboids
subclavius
what 3 muscles extend from scap and/or clav to humerus and produce mvmts at glenohum joint?
deltoid
teres major
rotator cuff: SITS
Deltoid: function, paralysis?
functions:
-abduction (after 90 degrees, more important in stabilizing head of humerus against glenoid fossa)
-adduction stabilizer--prevents unwanted medial rotation by other shoulder joint adductors
-flexion, extension
-rotation (stabilizing)

paralysis: limit shoulder joint abduction significantly!!!!
Teres Major functions?
shoulder joint adduction, extension, medial rotation

if its paralyzed, these things are inhibited
Rotator Cuff (SITS muscles)

Give functions of:
Supraspinatus?
Infra?
Teres Minor?
Subscap?
Supra: shoulder joint ABduction
Infra: Lateral Rotation of shoulder joint
Teres minor: shoulder joint lateral rotation
Subscapularis: shoulder joint *medial* rotation, adduction, extension
Muscles that extend b/t trunk and humerus and produce mvmts of shoulder girdle joints AND shoulder joint?
pec major, lat dorsi

depending which is fixed, muscles produce mvmt at either girdle or joint or BOTH
Pec Major

functions when humerus is fixed?

when shoulder girdle "fixed" and rib/axial fixed?

effects of paralysis?
humeral fixed:
-girdle protraction (pushup)
-girdle depression by sternal component of muscle (crutch walking, pushups, rising from sitting using arms)

w/ girdle fixed:
-glenohumeral joint flexion, adduction, medial rotation
-glenohumeral joint extension from flexed position, adduction, medial rotation

-w/ hands fixed body in position to do a pushup, pec major can assist in elbow joint extension during push up

paralysis: No significant disabilities for "daily" living
Lat Dorsi
shoulder girdle movement functions:
-depression of girdle (trunk attach fixed)
-downward rotation of glenoid fossa

shoulder joint mvmts:
-extension, adduction, medial rotation

paralysis:
-no probs for "normal" activities

hard time getting arm back to get sth out of back pocket
differences between bone and cartilage:
ECM?
blood supply?
appearance?
ECM of bone=CALCIFIED (cartilage is not). Calcium (mainly salts) distributed *precise* on high-ordered collagen fibers of ECM.
ECM arranged in layers called *lamellae*

blood supply: cartilage=diffusion
bone=blood vessels travel thru Haversian canals and marrow cavities: all enter bone thru NUTRIENT FORAMINA ON BONE SURFACE

appearance:
1. compact bone: outer surface of bones, made of lamellae packed closely together in Haversian Systems; APPEARS SOLID

2. spongy bone=interconnected network of bars of bone called trabeculae (trabeculae= "little beams")--these form network of marrow cavities

Blood Supply: CBlood vessels in Haversian canals deliver nutrients to osteocytes thru nutrient foramina.

*In trabeculae of songy bone: surrounded by small vessels thraveling in the endosteal layer, canaliculi extend to surface to allow processes (filopodia) from osteocytes to contact these vessels and distribute nutrients

NO DIFFUSION! :)
lacunae
holes in bone "swiss cheese" containiing osteocytes
periosteum

(and endosteum)
layer of connective tissue

LIKE perichondrium, outer fibrous layer and inner cell layer which can form new bone "osteogenic layer"

endosteum: b/t cortical and spongy bone investment of conn tissue--also has osteogenic component
compact bone
outer portion of bone, hard and dense, made of lamellae packed into Haversian Systems. HAS NO MARROW CAVITIES.
Harversian System/osteon
Lamellae arranged circumferentially around central circular canal containing a blood vessel

Central canal=Haversian canal

canal=parallel to surface of bone. Blood vessels in here provide nutrients to osteocytes, entering the bone thru *nutrient foramina*
Red Marrow

found where?
composed of what?
common in what parts of body?
found in TRABECULAE of spongy bone (these make marrow cavities)

-made of stem cells-->RBC production
-most abundant in young children, also ribs, sternum, iliac crest, bodies of vertebra,e ends of some long bones
Yellow Marrow:

contains lots of what?
when/where commmon?
function?
contains lots of fat

replaces red marrow as ppl grow

fat storage!! portions can revvert to red marrow if need more RBCs

i.e. move from low to high altitude need more RBCs
Trabeculae
Marrow cavities made in spongy bone

arranged in interlocking arches that correspond to calculated lines of stress!!
--related to initial deposition of collagen fibers of ECM
Osteocytes (compare to chondrocytes)
Like Chondro, located in lacunae, general maintenance of calcified ECM, homeostasis
canaliculi
Form channels/tunnels in Calcified ECM that extend b/t lacunae

Osteocytes have processes (filopodia), they travel w/in canaliculi and contact others w/ cell bodies in other lacunae, EXCHANGE NUTRIENTS and COMMUNICATIONS

**nO DIFFUSION thru ECM of bone!!**
intramembranous ossification
i.e. skull

membrane of dense connective tissue
membrane itself (periosteum)--its osteogenic layer (w/ osteoblasts) lays down bone on SURFACE of calvaria (appositional growth!!)

as this happens, bone on inner surface is broken down so appropriate thickness is maintained! (done by osteoclasts!)
endochondral bone formation

what bones?
5 steps?
bone REPLACES pre-existing cartilage model

bones of vertebrae, pelvis, base of skull, and LONG BONES in body: all appear as hyaline cartilage minis of adult bones in fetuses (2nd mo pregnancy)

1. Primary Ossification Ctrs in Long Bones
2. Growth of Long Bones b/t primary oss ctrs and birth
3. 2ndary Oss Ctrs
4. Growth of bones after birth, after 2ndry Oss Ctrs
Endochondral Bone Formation
1. Primary Oss Centers appearance: describe 3 events
1. Formation of Primary Ossification Center: Cartilage at mIDDLE of shaft begins to break down, bone begins to form on its remnants

stimuli:
1. midpoint of shaft, chondrocytes enlarge, lacunae expand, ECM of cartilage begins to calcify. Chondrocytes no longer get nutrients and they die, leaves cartilage skeleton
2. Perichondrium is transformed into periosteum. These make thin layer of bone around midpoint of shaft: PERIOSTEAL COLLAR (intramembranous ossification! its' forming a membrane!)
3. Blood Vessels form around bone and from periosteum of periosteal collar start to invade region of calcified cartilage, bring w/ it osteoclasts and blasts
Endochondral Bone Formation
2. Growth of long bones b/t primary ossif centers and birth:
Cartilage at each end of primary ossif ctr grows-- in length (interstitial growth) and diameter (appositional growth)

Ossification spreads from primary center outward.
At birth, long bones have shaft of BONE (diaphysis) w/ ends of cartilage (epiphyses)
Endochondral Bone Formation
Step 3. Appearance of 2ndary Ossif Ctrs
After birth, at cartilaginous ends of bones, 2nd ossif ctrs form (same 3 events as primary: ECM calcifies, periosteum forms, blood vessels invade)

2ndary centers of same bone do not occur at same time!! i.e. femur: first secondary ctr at distal end at time of birth; 2nd secondary ctr at proximal end at age 1.
Endochondral Bone Formation
Step 4. Growth of long bones after birth, after 2ndary ossif ctrs
Plate of cartilage b/t diaphyses and epiphyses=epiphyseal plate!

growth in length: cartilage cells in the plates proliferate, on diaph side--replaced by bone! (interstitial growth)

Closure of epiphyseal plates by abt age 20 (hormones influence!)
Traction Epiphyses
2ndary ossification centers that appear in relation to sites of muscle attachment

**TUBEROSITIES**

become more prominent when muscles are in heavy use

can be pulled away (Osgood Schlatter's) from bone BY muscle
Endochondral Ossification of Carpal and Tarsal bones: how is it different from long bones?!
don't have primary ctrs till AFTER BIRTH!

DO NOT have secondary ossif centers (except navicular bone)
Remodeling of Bone over Lifespan
change density in response to stress (weight lifter, runner, etc), nutrition, and hormone

# of osteoclasts increases w/ decrease in Calcium and increase in parathyroid hormone . Low Calcium=muscle tetany (spontaneous contraction). When osteoclasts break down bone, increase levels of calcium in blood (but decrease bone strength)

Osteoperosis=remodeling gone wild
bones brittle, subj to fracture
bones break down faster than produced
Literal meanings:
Periosteum
Endosteum
Osteoblast
Osteoclast
Osteocyte
Periosteum=around bone
endosteum=within bone
osteoblast=bone "sprout/germ/bud"
osteoclast=bone "breaking"
osteocyte=bone cell
Osteocytes: function?
-maintain ECM
-INITIATE REMODELING PROCESS: sense pressure changes in bone, trasmitted via chemical signals by osteocytes to blasts and clasts!
Femur: when does primary ossification center occur at distal end? when does it close?

proximal?
distal end: birth, closes age 20

proximal end: age 1, closes age 18
caput
head
collum

nuchal
neck

"back/nape"
truncus:

-thorax
-abdomen
trunk

chest

abdomen
osmos
shoulder
brachium
arm
ancon
elbow
antebrachium
forearm
manus
hand
carpus
wrist
digit I, pollex
thumb
digits II, II, IV, V
fingers
coxa
hip
femoral region
thigh
genu, genicular region
knee
patellar region

anterior genicular region
front of knee
popliteal region, posterior genicular region
back of knee
crus, crural region
leg
sural region/posterior crural region
back (calf) of leg
pes

-tarsus
-digit I, hallux
-digits II-V
foot

-ankle
-big toe
-other toes
anatomically: arm

leg

(what parts are they referring to?)
arm=upper limb b/t shoulder and elbow only!

leg: b/t knee and foot! no thigh!
axial skeleton components?

appendicular?
skull, vertebral column, sternum, ribs

appen: upper/lower limbs and their girdles
literal meaning of:
-sagittal
-acromion
-coracoid
-arrow

"point of shoulder"

"crow"
two surfaces of scapula in anatomical terms?
costal surface/subscapular fossa

dorsal surface: spine, supra/infraspinous fossae, acromion process
acromial angle?

scapular notch is on what border of scapula-medial, lateral, or superior border?
junction b/t SPINE of scapula and acro process

scap notch: superior border
glenoid fossa: where does biceps bracii attach?

triceps?
supraglenoid tubercle

infraglenoid tubercle
line extending b/t inferior angles of 2 scapulae is at spinous process of what vertebra?

medial end of scapular spine what spinous process?
T7

T3
humerus:

greater and lesser tubercles (prox or distal end?).
what separates the head of humerus from these 2?

what is just below anatomical neck?
proximal end

seprated by anatomical neck

just below: surgical neck (most commonly broken)
what separates greater and lesser tubercles on humerus?

where are deltoid tuberosity and radial groove?

distal end of humerus: lateral/medial epicondyles
intertubercular groove

slight ridges on either sides: medial and lateral crests

**deltoid tuberosity: midway thru shaft

**radial groove: posterior and inferior

epicondyles: attach for muscles of forearm

trochlea, capitulum
-olecranon fossa
-coronoid fossa
literal meanings:
coronoid
deltoid
intertubercular
olecranon
trochlea
fossa
coronoid: "like a crow's beak"
deltoid: "shaped like the letter delta/triangular"
intertub: "between a small lump"
olecranon: "head of elbow"

trochlea: "small wheel or roller"

fossa: "ditch"
in anat position, which bone is medial? ulna or radius?

what connects ulna and radius along length of shaft?

which bone has the trochlear notch?
**ULNA**

interosseus membrane

ulna has troch notch
literal meaning of:
styloid
capitate
hamate
pisiform
scaphoid
"long and tapered pillar"
"headed"
"hooked"
"pea-shaped"
"a kind of boat"
8 carpal bones

which one is sesamoid? (what does sesamoid mean?)
scaphoid (tubercle of scaphoid)
lunate
triquetrum
pisiform
trapezium (tubercle of trapezium)
trapezoid
capitate
handle (hook of hamate)

sesamoid=bone embedded w/in tendons of muscles
-**pisiform!**
what innervates the intrinsic back muscles?
dorsal rami of spinal nerves!!
fibrous joints:

what kind of tissue?
is there a joint cavity?
how much mvmt?
3 major groups/types?
DENSE fibrous collagenous tissue
NO cavity
little/no mvmt

3 groups:
sutures (skull)

gomphosis (tooth and socket bone)

interosseous membranes (radius/ulna; tibia/fibula)
Cartilaginous joints:

union by what?
joint cavity or no?
how much mvmt?
2 types?
union by cartilage (duh)

no cavity except in pubic symphysis**

little mvmt, except **vertebral column**=considerable mvmt all together

1. Hyaline Cartilage: i.e. epiphyseal plate of long bone!

2. Fibrocartilage: PUBIC SYMPHYSIS AND IV DISCS!!!
Synovial Joints:
1. space b/t elements?
2. articular surfaces covered by what?
3. vascularized or no?
4. What is a fibrous capsule?
5. What lines inner surface of joint capsule?
. Interarticular discs?
1. Space b/t skel elements="joint space"

2. Artic. surfaces covered by hyaline/articular cartilage.. This cartilage=NO PERICHONDRIUM!!

3. NOT VASCULARIZED, get nutrition by diffusion

4. Fibrous Capsule surrounds surfaces and connects elements=HOLDS THEM TOGETHER

5. Inner surface=synovial membrane=thin, highly vascularized conn. tissue membrane, makes synovial fluid

6. IV discs=conn tissue discs b/t surfaces, make them more congruous? facilitate mvmt? i.e. sternoclavicular disc!!!
Is the articular cartilage at synovial joints covered by perichondrium?

Synovial joints are avascular. BUT synovial MEMBRANE that lines the capsule: vascularized?
NO

syn membrane=highly vascularized, provides synovial fluid
How do synovial joints work?

"weeping lubrication"
as opposing cartilages touch, fuid is squeezed out, making a film of lubricant. As pressure CEASES, fluid goes back into cartilages like h2o into a sponge. "weeping lubrication"
Examles of:
1. Uniaxial Joint
2. Biaxial Joint
3. Multiaxial Joint
1. Uni=ANKLE (talcocrural), humeroulnar (elbow), radioulnar
2. Biaxial: wrist, knee, fingers!
3. Shoulder/hip/sternoclavicular (?)
inversion/eversion of foot occurs at what joints?

intertarsal
tarsometatarsal
metatarsalphalangeal?
INTERTARSAL!
functional classification of radioulnar joint?
UNIAXIAL
thumb joint:
move thumb in sagittal plane: name ov mvmt?

coronal plane?
Sagittal=ab/adduction

Coronal=flex/extension
(**exception b/c thumb faces laterally!)
functional classification of:
metacarpophalangeal joint of thumb? (b/t trap and 1st knuckle)

FINGERS: metacarpal-phalangeal
(move in sag and coronal plane)
interphalangeal?
interphalangeal joint, thumb (1st and 2nd knuckle)
1. uNI
2. UNI
3. BI
4. UNIaxial
when knee is BENT, it can rotate in addition to flexion/extension.

therefore it is a ______ joint.
biaxial
metatarsophalangeal joints (toe connect to foot)

what mvmts? functional class?
flex, extend
ab/adduct

BIAXIAL
what 2 regions of spine have greatest degree of mvmt?

what portion of spine is fixed when talking abt joints?
CERVICAL and LUMBAR

caudal portion is FIXED : cervical mvmt=thoracic fixed; thoracolumbar mvmt=pelvis fixed
literal meaning of:
rhomboid
multifidis
"shaped like a rhomboid, having parallel planes"

mult: much/many, fid=to split into many parts