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216 Cards in this Set
- Front
- Back
Attach:
caudal: transverse processes of vertebrae crainal: spinous processes of vertebrae (answer is a large group of muscles) what are their functions? (4) |
transversospinae muscles
1. intervertebral extension 2. " abduction 3. rotation 4. semispinalis capitis extends the head |
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span 4 to 6 vertebrae from caudal (transverse process) to spinous process
one component attaches to back of skull? |
semispinalis
(cervicus attaches to vertebrae) semispinalis capitis attaches to head |
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span 2 to 4 vertebrae from caudal to cranial attachment
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multifidis
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transverse process of one vertebrae to spinous process/lamina of the adjacent (next one above) vertebra?
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SHORT rotators
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transverse process of a vertebra to spinous process/lamina of the second vertebra above
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LONG rotators
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attach to spinous process of upper thoracic and lower cervical vertebrae, cranial attachments to trans processes of cervical vert and skull
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splenius cervicus
splenius capitis (attaches to head) |
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functions of splenius cervicis/capitis
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-intervert. joint extension (ext of head by capitis)
-abduction -abduction of head by splenius capitis -intervert. rotation to side where muscle is contracting -rotation of head by splen capitis |
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attach at axis, atlas, occipital bone (muscle group)
innervated by first cervical nerve--maintain head in upright position |
Muscles of suboccipital Triangle:
rectus capitis posterior major obliquus capitis inferior ("inferior oblique" obliquus capitis superior |
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attach: spine of axis to occipital bone
function? |
rectus capitis posterior major
extends the head |
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spine of the axis to transverse process of the atlas
function? |
obliquus capitis inferior
rotates head to side on which muscle is contracting |
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from trans process of atlas and attaches to occipital bone
function? |
obliquus capitis superior
extend head |
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attach to anterior aspects of cervical vertebral bodies, transverse processes of vertebrae and occipital bone
flex head and heck when contracting bilaterally; when contracting on one side they assist in abduction of head/neck innervated? |
longus colli and longus capitis (whiplash muscles!!)
anterior muscles innervated by VENTRAL rami of spinal nerves |
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cranial attachment to trans process of 4-6 cervical vertebrae
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scalene muscles (anterior, middle, posterior)
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caudal atach: first rib
cranial: trans process C4-6 |
anterior scalene
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caudal attach: 2nd rib
cranial: trans process C4-6 (2 muscles have thiese attachments) muscle function? |
posterior and middle scalenes
flex neck when acting bilaterally, and laterally flex (abduct) and rotate neck and head when acting on one side only accessory respiratory: cranial attachments fixed, elevates ribs innervated by *ventral* rami of cervical spinal nerves |
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Scalenus Anticus Syndrome
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compression of brachial plexus and subclavian artery (these are b/t middle and anterior scalenes) due to increased muscle tone. symptoms: tingling in head, muscle weakness, loss of pulse in periph arteries of limb
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How do muscle fibers shorten?
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Sliding filament mechanism.
In presence of Calcium (cardiac), action potentials spread from motor neuron to motor end plate. Depolarization of membranes initiates cross-bridge cycling, actin and myosin slide past one another allowing the sarcomere to shorten. (skeletal) look up in phys? |
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Skeletal Muscle:
1. appearance? 2. shape/position of nucleus 3. how is it innervated 4. location |
1. striated b/c of organized myosin/actin filaments.
long, multinucleated cells 2. nuclei are oval, located at periphery 3. innervated by alpha motor neurons from CNS (voluntary muscle) 4. limbs, abs, etc. |
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Smooth Muscle:
1. appearance 2. shape/position of nucleus 3. innervated? 4. location? |
1. appears smooth
long, spindle-shaped cells w/ one oval nucleus 2. nucleus in middle 3. Innervated by AUTONOMIC NS. (as well as hormones, local stretch receptors) 4. walls of hollow viscera, walls and ducts of blood vessels, hair follicle (goosebumps) slowest to contract, longest to fatigue |
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Cardiac Muscle
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1. cross-striation (like skeletal!!) look striated!!!
but not arranged all parallel, but connected end to end w/ intercalc. discs. 2. One oval shaped nucleus in middle of cell 3. Innervated by SYMP and PARASYMP nerves (autonomic) 4. Located in the heart! *has richest blood supply 5. Less powerful than skel muscle but more resistant to fatigue |
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Which type of muscle fiber fatigues most easily?
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Skeletal
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What controls the degree of shortening in skeletal muscles?
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*ARRANGEMENT OF MUSCLE FIBERS* (parallel vs. penniform!!)
Parallel can shorten more! (therefore greater ROM) |
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What is atrophy?
hypertrophy? |
muscle fibers DECREASE in size
muscle fibers iNCREASE in size |
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how does muscle attach to bone? what is meant by harnessing?
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epimysium, perimysium and endomysium all come together to form tendon, which then attaches to periosteum of bone.
Force goes along this pathway to the bone. |
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Parallel v. penniform muscle fibers:
ROM? Force? |
Parallel has greater ROM, less force
Penniform has greater FORCE (more fibers in cross sectional area), less ROM |
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Type 1 muscle fiber
1. fast/slow? 2. color? why? 3. resistant to fatigue or no? 4. mitochondria? 5. what kind of metabolism/energy? 6. found where? |
1. Slow-twitch
2. red, lots of myoglobin 3. resistant to fatigue 4. lots of mitoch 5. OXIDATIVE METABOLISM (energy from fats/acids) 6. Found in INTRINSIC BACK MUSCLES nad soleus |
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Type 2 Fibers
1. fast/slow? 2. color? why? 3. mitoch? 4. resistant to fatigue/no? 5. energy source? 6. example? |
1. Fast-Twitch Fibers
2. White b/c of no myoglobin 3. few mitochondria 4. fatigue easily 5. energy from GLYCOLISIS--produces lactic acid 6. example: gastrocnemius |
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Epimysium, Perimysium, Endomysium
what are these made of? |
Epimysium is the connective tissue investment of the ENTIRE muscle. Epimysium=fascia!
Perimysium surrounds muscle fiber bundles called FASCICLES. Endomysium=connective tissue investment of INDIVIDUAL FIBERS made of COLLAGEN (these are areolar connective tissues) Conn. tissue makes up 15% of muscle! |
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Myotendinous Junction
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the point where endomysium and perimysium become continuous with one another beyond muscle fibers. (this is where force is transferred from muscle to tendon)
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Connective Tissue (muscle) Functions?
there are 5 |
1. Skeletal framework
2. Determines how much deformability/stretching/elasticity 3. Path for nerves, blood vessels, lymph 4. ATTACHMENT of muscles to bone and TRASMISSION Of force from muscle to bone 5. "Sink" for ions |
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List types of Nerve Fibers
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1. Somatic Motor Nerve
2. Proprioceptive Motor/Sensory 3. Sympathetic (autonomic) nerve fibers 4. General sensory fibers |
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Function of Somatic Motor Nerve Fiber to muscle fibers?
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-axons of alpha motor neurons that end at neuromusc. junction
Myelinated axons=fastest fibers in body, bring "gross" contraction of muscle |
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Sympathetic/autonomic nerve fibers (to muscle) function
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small, non-myelinated. Innervate smooth muscle of BLOOD VESSELS in a muscle!
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General sensory Nerve Fibers (to muscle) function?
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Convey pain, sensations from free nerve terminals on CONN. TISSUE SHEATHS of muscle
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Motor Unit definition?
What factors determine size of motor units? |
Alpha motor neuron and the muscle fibers it innervates
Factors: 1. muscle function 2. amount of force needed (as this increases, body will recruit more fibers via MORE ALPHA NEURONS!!) 3. CNS selective control 4. force diffuses thruout muscles |
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Isometric contraction
example? |
generates Force
(xb cycling ALWAYS generates force) INCREASED TENSION, BUT LENGTH STAYS SAME example: maintain body in erect posture |
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Isotonic Contraction?
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Tension increases, LENGTH changes.
1. concentric 2. eccentric |
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Concentric (isotonic) contraction
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Muscle fibers SHORTEN.
i.e. use biceps brachii to flex at elbow (pull>resistance) |
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Eccentric Contraction
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gradual elongation of muscle as tension increases
sitting down from standing, lowering dumbbell from flexed to extended pull<resistance |
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Prime Mover
Antagonist |
muscle consistently active in initiating and maintaining a movement
antagonist: muscles that wholly oppose the movement or initiate/maintain the *opposite movement i.e. biceps brachii in elbow flexion |
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Fixator
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When prime mover and antagonist contract together.
this STABILIZES joint, creates stable base on which other muscles may act **any given muscle can be fixator, prime mover, OR antagonist, depending on the mvmt!**` |
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What happens when a muscle loses sensory innervation?
Effects of complete denervation of muscle? Reversible? |
Poor proprioception and coordination. Loss of muscle tone at rest.
Complete denervation: Muscle fibers DEGENERATE. Gradually decrease in size, replaced by conn tissue **largely reversible for at least 12 months (electrical stim and massage of muscle can slow degeneration process). If w/in 12 months muscle will recover most of former strength |
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Major Function of Each:
1. Cell 2. Tissue 3. Organ 4. Organ System |
1. Basic unit capable of functioning independently; basic building block of the body!
2. Tissue: specialized in common direction to perform specific function (cover body surfaces, line cavities, connect things to one another, muscle=movement, nervous tissue--respond to stimuli) 3. Organ: 2 or more tissue types for a collective function 4. Organ System: homeostasis |
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Function of each:
1. Cell membrane 2. Nucleus 3. Mitochondria 4. Lysosomes 5. Endoplasmic Reticulum-Rough 6. Smooth ER 7. Golgi complex 8. Microtubules 9. Centrioles |
1. Cell Membrane: passive/active transport across, receptors that influence cell function
Modifications: microvilli, cell junctions, cilia, receptor molecules, phagocytosis 2. Nucleus: genetic material, DNA, makes RNA, which is necessary for protein synthesis 3. Mitochondria: ENERGY/ATP 4. Lysosomes: full of enzymes--BREAK DOWN LARGE MOLECULES 5. RER: HAS RIBOSOMES AND MAKES PROTEINS 6. SER: no ribosomes, synthesizes FAT, drugs/alcohol/toxins 7. Golgi: STORES proteins! 8. Microtubules: form skeleton of neurons and other cells (filament-like cells) i.e. actin/myosin parts of muscle cells 9. Centrioles: distribute chromosomes to daughter cells during meiosis and mitosis (mature cells DO NOT have them and can't divide) |
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In what type of cell would you expect to find lysosomes?
RER? Lots of SER? lots of Golgi? lots of microtubules? lots of centrioles? |
ots of lysosomes in MACROPHAGES/anything that is going to break down large molecules
Lots of RER in protein synthesizing cells Lots of SER in liver cells (break down toxins) lots of golgi in cells that SECRETE proteins, i.e. thyroid gland, pancreatic cells lots of microtubules in muscle cells (myofilaments) centrioles in mitotic/meiotic cells? (look up) embryonic/stem cells |
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What are junctional complexes (cellular level)?
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between 2 cells: tight junction (prevents material from passing b/t cells)
gap junctions (cell to cell communication) adhering junctions |
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Microvilli
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modified plasma membrane
free surface FOLDED, looks like projections. i.e. small intestine |
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Cilia
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hair-like PROCESSES that extend from surface, NOT MODIFIED MEMBRANE LIKE MICROVILLI!
made of microtubules "move/beat" found in respiatory tract, repro tracts |
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phagocytosis/pinocytosis
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pino=process where small drops of fluid incorporated into cell
phago=duh. envelops. once in cell=phagocytitic vesicle, can be attached by other organelles i.e. white blood cells and macrophages!! must digest toxins |
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Distinguishing characteristics of epithelia?
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"sheets" of cells (either single layer or multi)
-adjacent cells w/ little/no intercellular substance 1. basement membrane 2. avascular but innervated (nerves don't pierce or travel thru epithelia, but some epi have receptor cells) **no blood=receive nutrients from diffusion from caps in underlying conn tiss 3. Specialized Junctions--cell communication and adherence 4. Mitosis: i.e. skin cells sloughed up and constantly remade |
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Basal Lamina/Basement Membrane of epithelial cells-what is it made of? what is it's function?
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made of thin layer of protein fibers and complex carbs (produced by epithelial cells OR conn tissue)
anchors cells to underlying tissue |
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Simple Squamous Epithelium
Layers/Cell Shape? Function? Location? |
1 Layer, flat cells
function: absorption/diffusion location: lining of heart, blood and lymph vessels, thoracic and abdominal cavities, air sacs of lung |
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Stratified Squam Epithelium
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multilayered, flat cells
function: PROTECTION location: outer layer of skin, lining oral cavity, esophagus, vagina (places it's sloughed off=many layers ok!) BASAL CELLS DIVIDE to replace lost cells! |
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Simple Columnar Epithelium with microvilli
function? location? |
one layer, column cells
function? ABSORPTION location? SI lining |
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Pseudostratified Columnar Epithelium, ciliated
function? |
Appears to be stratified but really just one layer, columnar cells
function: mvmt of stuff OUT of body location: upper respiratory tract lining |
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Transitional Epithelium
location/function |
location: bladder
function?: accommodate distension of bladder |
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simple cuboidal epithelium
function/location? |
secretion/absorption
location: lines kidney tubules/ducts, surface of ovary, inner surface of cornea and eye lens |
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Stratified Cuboidal Epithelium
Function? |
Protection!!
Location: ducts of adult sweat glands |
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Simple Columnar Epithelium
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absorption/secretion
location: stomach and SI lining |
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Stratified Columnar Epithelium function/location?
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protection/secretion
location: part of male urethra (only location) |
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What is a gland? (tissue type, examples)
How do multicellular glands develop? |
Made of epithelial tissue specialized for *secretion*
may be single celled or multi Multi glands: epi tissue in a region has proliferated and invaginated INTO underlying tissue to form a gland made of many cells examples: liver, pancreas, salivary, endocrine |
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Endocrine vs. exocrine glands?
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Endocrine releases substance INTO blood stream to be carried around and THEN hit its target cell/tissue (pituitary, thyroid, adrenal, testes/ovaries, ENDOCRINE portion of pancreas that produces insulin)
Exocrine releases substance INTO **duct, then they empty onto surface of target epithelial tissue (i.e. sweat, salivary, subaceous glands, exocrine components of pancreas/liver) |
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What cell types are found in connective tissue? (2 types w/ 3 subtypes. Name 2 major ones and describe)
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1. Fixed Cells: STAY WITHIN confines of CONN TISSUE itself. Do not move b/t conn tissue and blood stream. They can move around, just w/in these confines.
2. Wandering Cells: move in and out of bloodstream as well as w/in conn tissue itself (i.e. deliver large nos of specific cell types to region where needed, i.e. inflammatory response) |
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Types of Fixed Cells (in Connective Tissue)
3 types |
1. Fibroblasts: synthesize and secrete ground substance and fibrous elements that form the ECM of conn tissue (means "fiber-forming cell")
2. Fat Cells: COLLEct fat droplets in cytoplasm. The lipid molecules form a single large droplet/vacuole--puts nucleus and cytoplasm to periphery function: energy storage, h2o storage, insulation, protection 3. Macrophages: phagocytosis, immune response, scar formation 2. Fat Cells 3. Macrophages |
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Types of Wandering Cells (in Conn Tissue)
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1. Mast Cells: common near blood vessels, secrete *heparin and *histamine
2. Plasma cells: mostly found in conn tiss of LI and SI **produce antibodies!!* (immune) 3. Blood Cells: RBCs stay in blood stream; other cells (WBCs, monocytes, lymphocytes, etc) move b/t blood and conn tiss--inflammatory/immune response |
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Histamine =what does it do?
(released by mast cells of conn tissue) |
VASODILATOR
Increases permeability of capillary beds, allowing fluid to leak into Extracellular space (swelling) |
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3 Fiber Types found in Connective Tissue?
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Collagen, Elastin, Reticular Fibers
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Collagen Fibers function?
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-made by fibro, osteo, and chondroblasts
consist of fibrils/microfibrillar units -STRENGTH OF STEEL -straight or wavy. Can be straightened by pulling, but LITTLE/NO stretching!!! -tendons, ligaments, joint capsules |
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Elastic Fibers Function?
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made of elastin, CAN be stretched, become less resilient w/ age
many in external ear made by fibro and chondroblasts |
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Reticular Fibers
made of? function? |
made of special type of collagen
arranged in networks and iNELASTIC form supptortive network for cells of many structures (like lymph nodes and blood forming organs) |
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Biosynthesis of Collagen Fibers:
what components of cell are involved? |
1. On RER: polypeptide chains are MADE
2. Chains group together to make triple helices=procollagen molecules 3. Procoll mols go to Golgi 4. On Golgi--modified into COLLAGEN molecules. These go to cell exterior to form part of ECM 5. Then aggregate to form collagen fibers |
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Collagen biosynthesis
1. type of collagen produced depends on ______? 2. What determines how fibers line up? What is the diff b/t collagen found in bone and collagen found in cartilage |
Type produced depends on HOW chains aggregate
2. Fibers line up PARALLEL to FORCES to which developing tissue is exposed! Bone is type 1 collagen forms bc of arrangement of alpha chains AND in response to stress! Type 2: ONLY in cartilage (3 alpha one chains) |
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What are the components of ground substance? are they living?
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NON-LIVING material in which cells and fibers are embedded
made up of Carbs and Protein molecules called glycosaminoglycans + h2o, sugar, calcium salts |
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what is responsible for development of primary curvatures of spine?
2.secondary curves? |
different height b/t front/back of vertebral bodies
2. intervertebral discs |
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Lordosis
-which curvatures? -causes? |
"sway back"
secondary curvature cause: poor posture, pregnancy, weak abs/tight low back |
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Kyphosis
-which curves? causes? |
primary curves
"hunch back" -poor posture, bone deformities, osteoperosis/age, abnormal intervertebral discs |
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Scoliosis
-curves? causes? |
curve in coronal plane
cause: unknown, congenital, unilateral paralysis of intrinsic back muscles, one leg shorter than the other |
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Anterior Longitudinal Ligament
location? function? |
anterior of vertebral body
limits hyperextension, reinforces intervert. discs |
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Posterior Longitudinal Ligament
location? function? |
located in vertebral canal on posterior side of vertebral body
does NOT reinforce discs |
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Ligamentum Flavum
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ligamentum flavum located posterior side of vertebral canal (side of the hole nearest spinous process)
slows flexion of spinal column, help erection of spine (i.e. after bent over)--VERY ELASTIC! |
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Major components of an intervertebral disc? (3)
What are their functions? |
anulus Fibrosus: dense fibrous tissue attached to periphery of bodies of adj. vertebrae
thick anterior (thin posterior--hence slipped discs) Nucleus Pulposis: "jelly donut," 80% h2o, center of disc surr. by anulus, changes shape 4 mvmts BUT incompressible 3. hyaline cartilage: covers articulating surfaces of vert. bodies; function--GROWTH of discs and verte. bodies, pathway for nutrients to discs from marrow cavity of vertebrae |
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In what region is herniation of a disc likely to occur? Why?
What is sciatica? |
bulging thru the weak part of a "tire" (anulus) is called "herniation of the nucleus pulposus"
-usually posteroLATERAL b/c column is usually FLEXED when stresses upon it most frequently LUMBAR, esp b/t L4 L5 or L5 and sacrum , sometimes cervical Sciatica: on side of herniation, spinal rootlets are compressed, causing scoliotic curve concavity on side of herniation (b/c muscles on other side are still contracting to pull you up, but no contrxn on herniated side) Usually compress roots L5/Sacral, pain felt down back and lateral sides of legs radiating to foot Sciatica: |
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How does sagital orientation of lumbar synovial joints affect rotation/flexion and extension?
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these mvmts occur mainly at lumbar region b/c of thoracic spine limitations (rib cage, int discs). can "camouflage" their limited-ness by mvmt at hip joints
Cervical: flexion/extension/lateral bending are SUMS of mvmts at atlanto-occ, lateral atlanto-axial, and other cerv. joints. atlanto-ax joint: rotation of head |
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what movements occur at occipital bone and atlas? what muscles involved?
axis and atlas? what muscles? |
flexion (chin to chest),
muscles: rectus capitis, longus capitis, SCM **extension muscles: rectus, superior oblique, splenius cap, longissimus cap, trap atlas and axis: rotation of head (chin level w/ shoulders) -inferior oblique, SCM, semispinalis |
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how might scoliotic curve develop in someone w/ one leg shorter than other?
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-tone on one side pulls spine to that side aaand slightly rotates it, leading to rib deformity, respiratory problems, vertebral deformity, and compensatory cervical curve
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location and function of longus capitis and colli muscles?
what can happen if they're hyperext? |
attachments: anterior cervical vertebral bodies, transverse processes of vertebrae, to occipital bone
function: head flex/ext when bilateral contrxn unilateral: abduction/lateral flexion to either side trauma=whiplash |
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position/function of:
anterior scalene middle scalene posterior scalene |
anterior: 1st rib to transverse processes C4-C6
posterior and middle scalenes: 2nd rib to transverse C4-6 function: blex neck (bilateral) unilateral--abduct, rotate head accessory breathing muscles |
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literal meanings of:
pia mater aracnoid dura mater cauda equina |
delicate mother
spider-like tough mother horse tail |
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arachnoid trabeculae
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branching strands of arachnoid (on its inner surface) that pass THRU subarachnoid space and attach to Pia Mater
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composition:
dura mater, arachnoid, pia diff b/t meningeal covers in cranial cavity vs. vertebral canal? why? |
dura=collagen
arachnoid=loose conn tissue pia=loose conn tiss full of blood vessels cranial cavity=no epidural space verte canal: dural sac extends to sacrum, epidural space full of blood vessels--space allows mvmt of brain w/o affecting spinal cord |
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What is CSF? composition? where found? function?
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CSF=plasma-like fluid filling the SUBARACH space
function=support, buoyancy (spinal cord cannot hold up brain/itself |
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composition of grey matter?
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cell bodies of neurons, their dendrites, proximal parts of axons
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comp of dorsal horn
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incoming nerve fibers from ganglia
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dorsal roots composition?
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exclusively of sensory nerve fibers
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ventral horn composition?
ventral roots comp? |
large somatic motor neurons
roots: AXONS of these MOTOR neurons along w/ axons from AUTO NS |
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why gray matter enlarged at some spots?
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cervail/vertical bc of up/low limbs
thoracic have small vent horn BUT have a lateral horn w/ autonomic nerve cell bodies |
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white matter composition
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myelinated nerve fibers that run up /down cord to/from CNS
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dorsal ramus contains?
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SENSORY AND MOTOR neurons going to back muscles, trunk, neck
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Ventral ramus contains?
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SENSORY AND MOTOR neurons going to the rest of the body
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what is a dermatome? clinical corre?
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area of skin innervated by specific spinal nerve
clinical: Shingles! viruses transported VIA axons. when immune system is weak, they travel back out to the skin and produce rash |
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what segmental level of spine innervates umbilicus?
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T10
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layers needle goes thru to get to subarachnoid space
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skin and subcutaneous tissue
ligamentum flavum epidural space dura mater subdural space arachnoid subarachnoid space |
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What type of tissue makes up epidermis?
Dermis? |
epi=stratified squamous epithelium
dermis: loose regular connective tissue that contains ALL cell and fiber types of connective tissue!!! |
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What are characteristics of stratum basale and stratum corneum?
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stratum basale=alive, mitotic, DEEPEST layer of epidermis.
function: maintenance of epithelial component of skin (to compensate for cells being sloughed off) stratum corneum: most superficial layer, DEAD, keratinized cells function: resist passage of fluids/substances/friction. thickness varies thruout body, cells constantly being sloughed |
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How does skin become keratinized? Where?
Describe someone w/ hyperkeratosis. |
Skin becomes keratinized on the epidermis. It is the process of skin becoming scale-like, dead
Keratohyaline made by cells near the stratum basale, interacts w/ cells and transforms them into dead ones. End product is barrier, waterproofing, protection, defense from infection hyperkeratin; orange! |
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Function of melanocytes?
langerhans cells? where are they located? |
make melainin (pigment) protects deeper layers from UV rays
-langerhans=MACROPHAGES that activate immune system, another line of defense |
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What major cell/fiber types are found in dermis?
Describe position/location of papillary and reticular layers of dermis (relative to epiderm) |
**ALL**
part of dermis RIGHT next to dermis=capillaries and nerve endings=**papillary layer** Reticular Layer: depper portion, DENSELY interwoven tissue, more collagen and elastic, 75% of epid. thickness |
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What are dermal papillae?
What structures are within? Or associated w/? |
papillae: nipple-like projections from papillary layer of dermis that fit into indentations on the surface of epidermis==anchored TOGETHER
-EPi obtains nutrients via diffusion from vessels in pap layer |
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hair follicle and subaceous glands and sweat glands are all derived from what layer of skin?
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*8basal layer of epidermis
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what are tension lines of skin?
how would you make an incision on abdominal wall? at wrist? |
collagen/elastic fibers oriented parallel to lines along which skin is folded during mvmt
lines are determined by sticking sharp rounded obj into cadaver that leaves a slit-wound in fibers' direction CUTS SHOULD BE MADE IN THE DIRECTION OF THESE LINES, skin gapes less widely, less scar tissue |
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individuals' hair growth is dependent on what?
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high mitotic activity of epidermis basal layer
chemotherapy destroy most rapidly dividing cells in body (like epi cells, hence hair loss) |
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Function of sweat glands and arrector pili muscles (muscles that cause hair to stand on end) are modulated by __________ component of nervous system?
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*sympathetic (autonomic)
regulates temperature ppl w/ spinal cord injury in region of symp nervous system can't sweat--must use spray bottle, AC, be careful, etc. |
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how do decubitus ulcers develop?
how are layers of skin affected by 1st, 2nd, 3rd degree burns? |
ulcers/bedsores: area of skin is close to bone and undergoes constant pressure (i.e. being bedridden). this compresses blood vessels, leads to tissue/cell death
1st: epidermis damaged not destroyed; redness, pain. i.e. sunburn 2nd: destroy epidermis, some damage to dermis --blisters, moist surface due to plasma loss, nerve endings still in tact!! may be scarring, need treatment 3rd degree: destroy epi, dermis, AND underlying tissue -nerve endings destroyed, skin can't regenerate, white/charred appearance, loss of body fluids, surgery ALWAYS necessary |
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Chondroucoprotein
Lacunae Perichondrium (define) |
glycoprotein that makes up the ground substance of ECM of cartilage. Collagen fibers are embedded in this substance.
Perichondrium: dense layer of connective tissue investing cartilage Lacunae: circular compartments of cartilage's ECM--inside are chondrocytes ("swiss cheese holes") |
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How do cartilage cells get nutrients, O2, etc?
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diffusion thru ground substance from vessels in tissue surrounding cartilage
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Characteristics of 3 main types of cartilage? Location?
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1. Hyaline: LOTS of ground subst, collagen fibers
**embryonic skel, articular cartilage, larynx, trachea, costals 2. Elastic: yellow, fibrous, ELASTIC fibers in ground subst **ear, auditory tube 3. Fibrocartilage: white, "regular" collagen, small ground subst **intervert discs, pubic symphysis |
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Cartilage growth:
1. Interstitial 2. Appositional |
1. Inter: from within. Each cart. cell in lacuna secretes large amts of new matrix material (chondroblast). Cartilage expands.
2. Appo: deposit ECM around surface. Cells in layer of perichondrium synthesize extracellular Matrix of cartilage, size increases. |
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Chondroblast vs. chondrocyte function?
what types of cell organelles in each? |
Blast=produce the MATRIX of cartilage that leads to GROWTH of cartilage
(lots of RER=makes proteins)? CYTE=maintain ECM of cartilage lots of RER? rigid? umm... ** look this up!!:) |
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literal meanings of:
lacuna perichondrium chondrocyte chondroblast interstitial appositional |
lacuna=hole/pit
perichondrium="around cartilage" chondrocyte="cartilage cell" chondroblast="cartilage sprout/germ/bud" interstitial: "between" appositional: "united/applied" |
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What are the joints of the shoulder girdle? (2)
what movements occur at each? what ligaments assoc w/ each? Are the joints uni, bi, multiaxial?) Why? |
Sternoclavicular Joint: elevation/depression, protraction/retraction, up/down rotation of glenoid fossa
ligaments: sternoclavicular, interclavicular, costoclavicular Acromioclavicular Joint: "gliding" movements Ligaments: coracoclavicular (conoid and trapezoid), coracoacromial lig Multiaxial Spherical Nature of articular surfaces and Fibrous discs b/t surfaces |
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Location and Function of:
Sternoclavicular Ligaments (2) |
Anterior and Posterior ligaments
Link to axial skeleton (anterior b/t sternum and clavical in the front, posterior link b/t sternum and clav in the back) thickening of joint capsule itself (intra-capsular ligs), limit movement in all directions |
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Location and function of costoclavicular ligamentq
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between 1st rib and clavicle (bilaterally)
LImits unwanted superior mvmt of clavicle, fulcrum for some clavicle mvmt |
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location and function of interclavicular lig
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between *sternal* ends of 2 clavicles, across the sternal notch
limits unwanted/excessive depression of shoulder girdle |
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location/function of coracoclavicular ligaments (2-names?)
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1. Conoid Ligament (more medial)
2. Trapezoid Lig (more lateral) Location: strong union b/t scapula and clavicle--connect clavicle and coracoid process! limit unwanted mvmt b/t scapula and clavicle **these are usually torn during shoulder separation, *but* stronger than bone itself--clav will fracture before they're broken |
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location/function of coracoacromial ligament
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b/t coracoid and acromion processes of the scapula (2 processes of SAME BONE): forms roof over head of humerus, prevents unwanted superior mvmts of humeral head, separates supraspinatus muscle from deltoid muscle
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What is the glenoid Labrum? functions?
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structure that "deepens" glenoid fossa
fibrocartilaginous ring that attaches at circumference of glenoid fossa maintains uniform film of synovial fluid across joint surface (and deepens fossa) |
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What is meant by scapulohumeral rhythm?
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movements at glenohumeral joint occur in concert w/ mvmts of shoulder girdle!! If one doesn't work, neither does other, etc.
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Movements at glenohumeral joint? (flex, extend? etc)
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flexion extension, ab/adduction, rotation, and any combo
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Scapulohumeral Rhythm:
What shoulder girdle mvmts accompany shoulder joint ab/adduction? What muscles involved? |
Shoulder joint ab/adduction=upward/downward rotation of glenoid fossa
muscles: (ab)=upper trap, serratus anterior, lower trap ad: levator scapulae, rhomboids, lats, pecs |
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What would happen to full range of shoulder joint flexion (abduction) if muscles of shoulder girdle are paralyzed?
What position will shoulder girdle assume w/ paralysis of girdle muscles? |
If shoulder girdle muscles are paralyzed, shoulder joint flexion/extension probably will not happen at all or very minimally.
Shoulder girdle muscles paralyzed (i.e. serratus ant)=downward rotation of the glenoid fossa b/c of weight of arm itself, posterior mvmt of scapula ("winging") b/c normally muscles keep scapula tight against body wall. |
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Shoulder separation
vs. Shoulder dislocation |
1. acromioclavicular joint: usually trauma to joint capsule, broken clavicle and/or torn ligaments (conoid/trapezoid ligs)
2. Dislocation: displacement of head of humerus from glenoid fossa, usually anterior/inferiorly. May stretch/tear joint capsule. Rotator cuff muscles: supraspinatus, infraspinatus, teres minor, subscapularis ("SITS") |
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What is a bursa?
Where are they found? Show/describe in words location of 1. subacromial bursa 2. subdeltoid bursa |
Bursa=flattened sac of connective tissue lined by synovial membrane w/ small amt of synovial fluid
found b/t structures in close contact w/ each other (to prevent friction) subacromial: b/t acromion process of scapula and supraspinatus tendon (which is on top of the joint capsule, superior to humerus subdeltoid bursa: b/t delt and humeral head |
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What muscles form rotator cuff?
attachments? functions: 1. mvmts of shoulder joint? 2. maintaining integrity of shoulder joint? |
SITS: supraspinatus, infraspinatus, teres minor, subscapularus
proximal attachment: dorsal/costal surfaces of scapula distal: blend w/ parts of shoulder joint capsule as tendons reach shoulder joint capsule, they blend w/ it and form a "cuff" around the joint on all sides except inferior 1. Movements: ??? Look up in Book*** 2. Integrity: maintain head of humerus in glenoid fossa, prevent dislocation |
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Muscle Attachment
Function What happens if paralyzed TRAPEZIUS |
proximal attachment at skull and vertebral spine, distal attachment scapular
when distal attach fixed, moves head and neck @ atlanto-occipital joint proximal attach fixed: maintain shoulder girdle in approp position, move/stabilize girdle during abduction and flexion of arm Functions: -shoulder girdle elevation - " " retraction -upward rotation of glenoid fossa Paralysis: -exaggerated girdle depression -some weakness in elevation -abduct/flex arm diminished b/c weakness in ability to rotate fossa |
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Attachments?
Function? Paralysis effects? RHOMBOID1 |
attachment: ?? * look up
functions: -shoulder girdle elevation -downward rotation of glenoid fossa (adduction/ext of arm) shoulder girdle retraction paralysis: scapula tends to protract b/c of free limb -decreased ability to extend/adduct arm |
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LEVATOR SCAPULAE
attach? function? paralysis effects? |
attach?
functions: shoulder girdle elevation shoulder girdle protraction paralysis: other muscles can assume almost completely its function |
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attach/function/paralysis effects?
Pectoralis Minor |
function:
downward rotation of glenoid fossa -protract shoulder girdle -depress shoulder girdle paralysis: affect one's ability to downward rotate glen fossa, and component of ext/adduction of arm (scapulohum rhythm) |
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function/paralysis effects?
Serratus Anterior |
**like trap!**
-upward rotation of glenoid fossa during abduction/flexion of arm -approp position of girdle on chest wall -STRONG protractor -shoulder girdle depression Weakness/Paralysis: -"winging" of scapula -impossible to do pushup if bilaterally paralyzed -can't abduct/flex shoulder joint (b/c can't upwardly rotate glen fossa) -if both serr and trap are paralyzed, can't abduct/flex arm, overall mvmt/position of girdle=awful |
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Subclavius
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-depressing clavicle
-stabilize clavicle |
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what 4 muscles extend from trunk to scapula/ and clavicle and produce mvmts of shoulder girdle?
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trapezius
serratus anterior rhomboids subclavius |
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what 3 muscles extend from scap and/or clav to humerus and produce mvmts at glenohum joint?
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deltoid
teres major rotator cuff: SITS |
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Deltoid: function, paralysis?
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functions:
-abduction (after 90 degrees, more important in stabilizing head of humerus against glenoid fossa) -adduction stabilizer--prevents unwanted medial rotation by other shoulder joint adductors -flexion, extension -rotation (stabilizing) paralysis: limit shoulder joint abduction significantly!!!! |
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Teres Major functions?
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shoulder joint adduction, extension, medial rotation
if its paralyzed, these things are inhibited |
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Rotator Cuff (SITS muscles)
Give functions of: Supraspinatus? Infra? Teres Minor? Subscap? |
Supra: shoulder joint ABduction
Infra: Lateral Rotation of shoulder joint Teres minor: shoulder joint lateral rotation Subscapularis: shoulder joint *medial* rotation, adduction, extension |
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Muscles that extend b/t trunk and humerus and produce mvmts of shoulder girdle joints AND shoulder joint?
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pec major, lat dorsi
depending which is fixed, muscles produce mvmt at either girdle or joint or BOTH |
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Pec Major
functions when humerus is fixed? when shoulder girdle "fixed" and rib/axial fixed? effects of paralysis? |
humeral fixed:
-girdle protraction (pushup) -girdle depression by sternal component of muscle (crutch walking, pushups, rising from sitting using arms) w/ girdle fixed: -glenohumeral joint flexion, adduction, medial rotation -glenohumeral joint extension from flexed position, adduction, medial rotation -w/ hands fixed body in position to do a pushup, pec major can assist in elbow joint extension during push up paralysis: No significant disabilities for "daily" living |
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Lat Dorsi
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shoulder girdle movement functions:
-depression of girdle (trunk attach fixed) -downward rotation of glenoid fossa shoulder joint mvmts: -extension, adduction, medial rotation paralysis: -no probs for "normal" activities hard time getting arm back to get sth out of back pocket |
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differences between bone and cartilage:
ECM? blood supply? appearance? |
ECM of bone=CALCIFIED (cartilage is not). Calcium (mainly salts) distributed *precise* on high-ordered collagen fibers of ECM.
ECM arranged in layers called *lamellae* blood supply: cartilage=diffusion bone=blood vessels travel thru Haversian canals and marrow cavities: all enter bone thru NUTRIENT FORAMINA ON BONE SURFACE appearance: 1. compact bone: outer surface of bones, made of lamellae packed closely together in Haversian Systems; APPEARS SOLID 2. spongy bone=interconnected network of bars of bone called trabeculae (trabeculae= "little beams")--these form network of marrow cavities Blood Supply: CBlood vessels in Haversian canals deliver nutrients to osteocytes thru nutrient foramina. *In trabeculae of songy bone: surrounded by small vessels thraveling in the endosteal layer, canaliculi extend to surface to allow processes (filopodia) from osteocytes to contact these vessels and distribute nutrients NO DIFFUSION! :) |
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lacunae
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holes in bone "swiss cheese" containiing osteocytes
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periosteum
(and endosteum) |
layer of connective tissue
LIKE perichondrium, outer fibrous layer and inner cell layer which can form new bone "osteogenic layer" endosteum: b/t cortical and spongy bone investment of conn tissue--also has osteogenic component |
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compact bone
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outer portion of bone, hard and dense, made of lamellae packed into Haversian Systems. HAS NO MARROW CAVITIES.
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Harversian System/osteon
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Lamellae arranged circumferentially around central circular canal containing a blood vessel
Central canal=Haversian canal canal=parallel to surface of bone. Blood vessels in here provide nutrients to osteocytes, entering the bone thru *nutrient foramina* |
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Red Marrow
found where? composed of what? common in what parts of body? |
found in TRABECULAE of spongy bone (these make marrow cavities)
-made of stem cells-->RBC production -most abundant in young children, also ribs, sternum, iliac crest, bodies of vertebra,e ends of some long bones |
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Yellow Marrow:
contains lots of what? when/where commmon? function? |
contains lots of fat
replaces red marrow as ppl grow fat storage!! portions can revvert to red marrow if need more RBCs i.e. move from low to high altitude need more RBCs |
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Trabeculae
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Marrow cavities made in spongy bone
arranged in interlocking arches that correspond to calculated lines of stress!! --related to initial deposition of collagen fibers of ECM |
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Osteocytes (compare to chondrocytes)
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Like Chondro, located in lacunae, general maintenance of calcified ECM, homeostasis
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canaliculi
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Form channels/tunnels in Calcified ECM that extend b/t lacunae
Osteocytes have processes (filopodia), they travel w/in canaliculi and contact others w/ cell bodies in other lacunae, EXCHANGE NUTRIENTS and COMMUNICATIONS **nO DIFFUSION thru ECM of bone!!** |
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intramembranous ossification
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i.e. skull
membrane of dense connective tissue membrane itself (periosteum)--its osteogenic layer (w/ osteoblasts) lays down bone on SURFACE of calvaria (appositional growth!!) as this happens, bone on inner surface is broken down so appropriate thickness is maintained! (done by osteoclasts!) |
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endochondral bone formation
what bones? 5 steps? |
bone REPLACES pre-existing cartilage model
bones of vertebrae, pelvis, base of skull, and LONG BONES in body: all appear as hyaline cartilage minis of adult bones in fetuses (2nd mo pregnancy) 1. Primary Ossification Ctrs in Long Bones 2. Growth of Long Bones b/t primary oss ctrs and birth 3. 2ndary Oss Ctrs 4. Growth of bones after birth, after 2ndry Oss Ctrs |
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Endochondral Bone Formation
1. Primary Oss Centers appearance: describe 3 events |
1. Formation of Primary Ossification Center: Cartilage at mIDDLE of shaft begins to break down, bone begins to form on its remnants
stimuli: 1. midpoint of shaft, chondrocytes enlarge, lacunae expand, ECM of cartilage begins to calcify. Chondrocytes no longer get nutrients and they die, leaves cartilage skeleton 2. Perichondrium is transformed into periosteum. These make thin layer of bone around midpoint of shaft: PERIOSTEAL COLLAR (intramembranous ossification! its' forming a membrane!) 3. Blood Vessels form around bone and from periosteum of periosteal collar start to invade region of calcified cartilage, bring w/ it osteoclasts and blasts |
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Endochondral Bone Formation
2. Growth of long bones b/t primary ossif centers and birth: |
Cartilage at each end of primary ossif ctr grows-- in length (interstitial growth) and diameter (appositional growth)
Ossification spreads from primary center outward. At birth, long bones have shaft of BONE (diaphysis) w/ ends of cartilage (epiphyses) |
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Endochondral Bone Formation
Step 3. Appearance of 2ndary Ossif Ctrs |
After birth, at cartilaginous ends of bones, 2nd ossif ctrs form (same 3 events as primary: ECM calcifies, periosteum forms, blood vessels invade)
2ndary centers of same bone do not occur at same time!! i.e. femur: first secondary ctr at distal end at time of birth; 2nd secondary ctr at proximal end at age 1. |
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Endochondral Bone Formation
Step 4. Growth of long bones after birth, after 2ndary ossif ctrs |
Plate of cartilage b/t diaphyses and epiphyses=epiphyseal plate!
growth in length: cartilage cells in the plates proliferate, on diaph side--replaced by bone! (interstitial growth) Closure of epiphyseal plates by abt age 20 (hormones influence!) |
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Traction Epiphyses
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2ndary ossification centers that appear in relation to sites of muscle attachment
**TUBEROSITIES** become more prominent when muscles are in heavy use can be pulled away (Osgood Schlatter's) from bone BY muscle |
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Endochondral Ossification of Carpal and Tarsal bones: how is it different from long bones?!
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don't have primary ctrs till AFTER BIRTH!
DO NOT have secondary ossif centers (except navicular bone) |
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Remodeling of Bone over Lifespan
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change density in response to stress (weight lifter, runner, etc), nutrition, and hormone
# of osteoclasts increases w/ decrease in Calcium and increase in parathyroid hormone . Low Calcium=muscle tetany (spontaneous contraction). When osteoclasts break down bone, increase levels of calcium in blood (but decrease bone strength) Osteoperosis=remodeling gone wild bones brittle, subj to fracture bones break down faster than produced |
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Literal meanings:
Periosteum Endosteum Osteoblast Osteoclast Osteocyte |
Periosteum=around bone
endosteum=within bone osteoblast=bone "sprout/germ/bud" osteoclast=bone "breaking" osteocyte=bone cell |
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Osteocytes: function?
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-maintain ECM
-INITIATE REMODELING PROCESS: sense pressure changes in bone, trasmitted via chemical signals by osteocytes to blasts and clasts! |
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Femur: when does primary ossification center occur at distal end? when does it close?
proximal? |
distal end: birth, closes age 20
proximal end: age 1, closes age 18 |
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caput
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head
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collum
nuchal |
neck
"back/nape" |
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truncus:
-thorax -abdomen |
trunk
chest abdomen |
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osmos
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shoulder
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brachium
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arm
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ancon
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elbow
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antebrachium
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forearm
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manus
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hand
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carpus
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wrist
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digit I, pollex
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thumb
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digits II, II, IV, V
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fingers
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coxa
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hip
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femoral region
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thigh
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genu, genicular region
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knee
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patellar region
anterior genicular region |
front of knee
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popliteal region, posterior genicular region
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back of knee
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crus, crural region
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leg
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sural region/posterior crural region
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back (calf) of leg
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pes
-tarsus -digit I, hallux -digits II-V |
foot
-ankle -big toe -other toes |
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anatomically: arm
leg (what parts are they referring to?) |
arm=upper limb b/t shoulder and elbow only!
leg: b/t knee and foot! no thigh! |
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axial skeleton components?
appendicular? |
skull, vertebral column, sternum, ribs
appen: upper/lower limbs and their girdles |
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literal meaning of:
-sagittal -acromion -coracoid |
-arrow
"point of shoulder" "crow" |
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two surfaces of scapula in anatomical terms?
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costal surface/subscapular fossa
dorsal surface: spine, supra/infraspinous fossae, acromion process |
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acromial angle?
scapular notch is on what border of scapula-medial, lateral, or superior border? |
junction b/t SPINE of scapula and acro process
scap notch: superior border |
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glenoid fossa: where does biceps bracii attach?
triceps? |
supraglenoid tubercle
infraglenoid tubercle |
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line extending b/t inferior angles of 2 scapulae is at spinous process of what vertebra?
medial end of scapular spine what spinous process? |
T7
T3 |
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humerus:
greater and lesser tubercles (prox or distal end?). what separates the head of humerus from these 2? what is just below anatomical neck? |
proximal end
seprated by anatomical neck just below: surgical neck (most commonly broken) |
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what separates greater and lesser tubercles on humerus?
where are deltoid tuberosity and radial groove? distal end of humerus: lateral/medial epicondyles |
intertubercular groove
slight ridges on either sides: medial and lateral crests **deltoid tuberosity: midway thru shaft **radial groove: posterior and inferior epicondyles: attach for muscles of forearm trochlea, capitulum -olecranon fossa -coronoid fossa |
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literal meanings:
coronoid deltoid intertubercular olecranon trochlea fossa |
coronoid: "like a crow's beak"
deltoid: "shaped like the letter delta/triangular" intertub: "between a small lump" olecranon: "head of elbow" trochlea: "small wheel or roller" fossa: "ditch" |
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in anat position, which bone is medial? ulna or radius?
what connects ulna and radius along length of shaft? which bone has the trochlear notch? |
**ULNA**
interosseus membrane ulna has troch notch |
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literal meaning of:
styloid capitate hamate pisiform scaphoid |
"long and tapered pillar"
"headed" "hooked" "pea-shaped" "a kind of boat" |
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8 carpal bones
which one is sesamoid? (what does sesamoid mean?) |
scaphoid (tubercle of scaphoid)
lunate triquetrum pisiform trapezium (tubercle of trapezium) trapezoid capitate handle (hook of hamate) sesamoid=bone embedded w/in tendons of muscles -**pisiform!** |
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what innervates the intrinsic back muscles?
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dorsal rami of spinal nerves!!
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fibrous joints:
what kind of tissue? is there a joint cavity? how much mvmt? 3 major groups/types? |
DENSE fibrous collagenous tissue
NO cavity little/no mvmt 3 groups: sutures (skull) gomphosis (tooth and socket bone) interosseous membranes (radius/ulna; tibia/fibula) |
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Cartilaginous joints:
union by what? joint cavity or no? how much mvmt? 2 types? |
union by cartilage (duh)
no cavity except in pubic symphysis** little mvmt, except **vertebral column**=considerable mvmt all together 1. Hyaline Cartilage: i.e. epiphyseal plate of long bone! 2. Fibrocartilage: PUBIC SYMPHYSIS AND IV DISCS!!! |
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Synovial Joints:
1. space b/t elements? 2. articular surfaces covered by what? 3. vascularized or no? 4. What is a fibrous capsule? 5. What lines inner surface of joint capsule? . Interarticular discs? |
1. Space b/t skel elements="joint space"
2. Artic. surfaces covered by hyaline/articular cartilage.. This cartilage=NO PERICHONDRIUM!! 3. NOT VASCULARIZED, get nutrition by diffusion 4. Fibrous Capsule surrounds surfaces and connects elements=HOLDS THEM TOGETHER 5. Inner surface=synovial membrane=thin, highly vascularized conn. tissue membrane, makes synovial fluid 6. IV discs=conn tissue discs b/t surfaces, make them more congruous? facilitate mvmt? i.e. sternoclavicular disc!!! |
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Is the articular cartilage at synovial joints covered by perichondrium?
Synovial joints are avascular. BUT synovial MEMBRANE that lines the capsule: vascularized? |
NO
syn membrane=highly vascularized, provides synovial fluid |
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How do synovial joints work?
"weeping lubrication" |
as opposing cartilages touch, fuid is squeezed out, making a film of lubricant. As pressure CEASES, fluid goes back into cartilages like h2o into a sponge. "weeping lubrication"
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Examles of:
1. Uniaxial Joint 2. Biaxial Joint 3. Multiaxial Joint |
1. Uni=ANKLE (talcocrural), humeroulnar (elbow), radioulnar
2. Biaxial: wrist, knee, fingers! 3. Shoulder/hip/sternoclavicular (?) |
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inversion/eversion of foot occurs at what joints?
intertarsal tarsometatarsal metatarsalphalangeal? |
INTERTARSAL!
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functional classification of radioulnar joint?
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UNIAXIAL
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thumb joint:
move thumb in sagittal plane: name ov mvmt? coronal plane? |
Sagittal=ab/adduction
Coronal=flex/extension (**exception b/c thumb faces laterally!) |
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functional classification of:
metacarpophalangeal joint of thumb? (b/t trap and 1st knuckle) FINGERS: metacarpal-phalangeal (move in sag and coronal plane) interphalangeal? interphalangeal joint, thumb (1st and 2nd knuckle) |
1. uNI
2. UNI 3. BI 4. UNIaxial |
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when knee is BENT, it can rotate in addition to flexion/extension.
therefore it is a ______ joint. |
biaxial
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metatarsophalangeal joints (toe connect to foot)
what mvmts? functional class? |
flex, extend
ab/adduct BIAXIAL |
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what 2 regions of spine have greatest degree of mvmt?
what portion of spine is fixed when talking abt joints? |
CERVICAL and LUMBAR
caudal portion is FIXED : cervical mvmt=thoracic fixed; thoracolumbar mvmt=pelvis fixed |
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literal meaning of:
rhomboid multifidis |
"shaped like a rhomboid, having parallel planes"
mult: much/many, fid=to split into many parts |