Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
NSAID= |
NSAID= Non Steriodal Anti-Inflammatory Drug |
|
|
Give 3 examples of an NSAID |
aspirin, ibuprofen, and diclofenac |
|
|
Which enzyme is inhibited by NSAIDs |
Arachidonicacid is released from cell membranes. Then a range of mediators are produced from this including theProstaglandins. Enzyme COX (Cyclooxygenase) is inhibited by NSAIDs so theyreduce prostaglandin levels, reducing pain and inflammation. |
|
|
Cox 2 inhibitors are used to treat... |
arthritis |
|
|
Which COX isoform is the main one in producing prostoglandins? |
COX-2 COX-1is really a house keeping enzyme expressed in most cells for produingprostoglandins for various functions. |
|
|
The difference between Aspirin and Ibuprofen is....? |
Ibuprofen is reversible and Aspirin is not. |
|
|
Which analgesic causes liver toxicity with high doses? |
Paracetamol |
|
|
Opiods are more effective for which type of pain? Nociceptive or Neuropathic? |
Nociceptive |
|
|
What type of receptor does an opiod act on? |
G -- protein couples receptor. The Mew receptor is the main receptor involved in most of the analgesic effects as well as side effects. |
|
|
The main danger of opiods is |
Respiratory Depression |
|
|
As well as interacting with G protein coupled receptors Opiods act on_________ |
K channels Vg Calcium channels. |
|
|
Opiods have an overall ___________effect on Neuronal activity |
Inhibitory |
|
|
What drug would you prescribe ( on occasion) for serious diarhhoea |
Codeine |
|
|
The inhibition of which enzyme has adverse GI effects? |
COX - 1 |
|
|
3 analgesics that are used for mild pain |
aspirin Paracetamol and NSAID's |
|
|
3 Drugs that are used for moderate pain |
Codeine, Oxycodone and Tramadol |
|
|
List 2 analgesics that are used for severe pain |
Morphine, Oxycodone, Methadone |
