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10 Cards in this Set
- Front
- Back
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Class
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Antidysrhythmic
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Mechanism of action
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Blocks sodium channels and myocardium potassium channels, delaying repolarization and increasing the duration of action potential
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Indication
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V-fib, pulseless ventricular tachycardia, unstable V-tach in pt refractory to other therapy
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Contraindications
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known hypersensitivity to amiodarone or iodine, cardiogenic shock, sinus bradycardia, 2nd or 3rd degree AV block (if no pacemaker present), severe sinus node dysfunction
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Adverse reactions/ side effects
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Dizziness, fatigue, malaise, tremor, ataxia, lock of coordination, adult respiratory distress syndrome, pulmonary edema, cough, progressive dyspnea, CHF, bradycardia, hypotension, worsening of dysrhythmias, prolonged QT interval, nausea, vomiting, burning at IV site, Stevens-Johnson syndrome.
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Drug interaction
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Use with digoxin may cause digitalis toxicity. Antidysrhythmics may cause increased serum levels. Beta Blocker and calcium channel blockers may potentiate bradycardia, sinus arrest and AV heart blocks
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How Supplied
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50 mg/mL vials and pre-filled syringes. For rapid infusion add 150 mg/3 mL to a 10 mL D5W run at 600 mL/h on infusion pump.
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Dosage and Admin
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Adult: V-fib/ pulseless V-tach unresponsive to CPR, defibrillation and vasopressors- 300 mg IV/IO push. Initial dose can be followed one time in 3/5 minutes at 150 mg IV/IO push. Maximum cummulative dose 2.2 g IV/24 h. Rapid infusion 150 mg IV/IO every 10 min as needed.
Pedi: refractory V-fib/pulseless V-tach 5 mg/kg IV/IO bolus up to a total dose of 15 mg/kg per 24 h. Maximum single dose 300 mg. Perfusing supraventricular and ventricular tachycardias: loading dose 5 mg/kg IV/IO over 20-60 min. Can repeat to a maximum dose of 15 mg/kg/day |
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Duration of action
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Onset:immediate
Peak effect: 10-15 minutes Duration: 30-45 min |
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Special Consideration
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Pregnancy safety: Cat. D. Monitor pt for hypotension. May worsen or precipitate new dysrhythmias
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