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8 Cards in this Set
- Front
- Back
What three strains are aminoglycosides produced from?
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Streptomyces spp, Micromonospora spp., and Bacillus spp.
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Aminoglycosides are the drug of choice for...?
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the treatment of serious aerobic gram negative infections in animals
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Are aminoglycosides bacteriostatic or bacteriocidal?
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bacteriocidal
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What two chemical factors increase toxicity on the aminoglycosides?
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increased number of free amino groups on the aminoglycosides and the more ionized the more toxic
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What is the most ionized aminoglycosides?
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neomycin
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What is the least ionized aminoglycoside?
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streptomycin
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What is the water and lipid sloubility of aminoglycosides?
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high water and poor lipid solubility
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What is the mechanism of action of aminoglycosides?
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exert bacterial action by entering the bacterial cell wall and inhibiting protein synthesis
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