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7 Cards in this Set

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Aminoclycosides are:
GRAM ___1___!
Pharmokinetics:
*Bacteria___2__
*Concentraion __3___
*Excretion via __4__ __4__ filtration
*not effective vs aneorobes
1. NEGATIVE
2. CIDAL
3. Dependent
4. Kidney glomerular
(too high can be nephrotoxic)
Aminoglycosides: Side Effects

*Nephrotoxicity
(neomycin is worst)
-Acute tubular __1__
-___2___ damage
-Related to __3__ of therapy
& __4__ or __5__ trough
concentration
-Risks: age, hypovolemia,
renal disease
1. necrosis
2. reversible
3. duration
4. high
5. prolonged
Aminoglycosides: Side Effects

*Ototoxicity
(streptomycin is worst)
-Damage to __1__ __2__
nerve
*Vestibular
(gant & strepto)
*Cochlear (amikacin)
Risk: total dose, ___3__ and peak concentration
1. 8th
2. Cranial nerve
3. Duration
Aminoglycosides
Think Gram _1__
*pseudomonas _2_, Proteus,
Enterobacter
*Serratia, e. coli
*NOT affective vs __3__

Gram __4__: used in Combo
*Entercococcus (_5_ + _6_)
*Staph Aureus
(_7__ + Vancomycin)
vanco not really a
aminoglycoside but share
many traits in pharmo-
kinetics
1. Negative
2. KLebesiella
3. Anaerobes
4. Positives
5. Penicillin
6. Vancomycin
7. Nafcillin
Aminoglycosides:
Special Use Agents
-Streptomycin: TB
-Neomycin:
*__1__ prep
*Hepatic __2____
*Topical ___3___
-Gentimicin & Tobramycin
*0__4___ use
1. Bowel
2. Encelphalopathy
3. Anibiotics
4. Ophthalmic
Aminoglycosides:
Dosing & Serum Levels

-Dosing intervals and mg/kg
doses are calculated on
complicated equations _1__

-Monitor ___2___ levels once
steady state is reached

-MOST IMPORTANT ARE
MONITORING OF __3__ & __4__
LEVELS!
1. Sawchuk-Zaske
2. serum
3. PEAK
4. TROUGH
Aminoglycosides Indications:
3 bacteria

Pat gets naked so pat never
pees!

Amikin: most __4__ reserved for bugs ___5__ to others
1. Psuedomonas
2. Gram negative Sepis
3. Gram negative pneumonia

4. expensive
5. resistant