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7 Cards in this Set
- Front
- Back
Aminoclycosides are:
GRAM ___1___! Pharmokinetics: *Bacteria___2__ *Concentraion __3___ *Excretion via __4__ __4__ filtration *not effective vs aneorobes |
1. NEGATIVE
2. CIDAL 3. Dependent 4. Kidney glomerular (too high can be nephrotoxic) |
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Aminoglycosides: Side Effects
*Nephrotoxicity (neomycin is worst) -Acute tubular __1__ -___2___ damage -Related to __3__ of therapy & __4__ or __5__ trough concentration -Risks: age, hypovolemia, renal disease |
1. necrosis
2. reversible 3. duration 4. high 5. prolonged |
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Aminoglycosides: Side Effects
*Ototoxicity (streptomycin is worst) -Damage to __1__ __2__ nerve *Vestibular (gant & strepto) *Cochlear (amikacin) Risk: total dose, ___3__ and peak concentration |
1. 8th
2. Cranial nerve 3. Duration |
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Aminoglycosides
Think Gram _1__ *pseudomonas _2_, Proteus, Enterobacter *Serratia, e. coli *NOT affective vs __3__ Gram __4__: used in Combo *Entercococcus (_5_ + _6_) *Staph Aureus (_7__ + Vancomycin) vanco not really a aminoglycoside but share many traits in pharmo- kinetics |
1. Negative
2. KLebesiella 3. Anaerobes 4. Positives 5. Penicillin 6. Vancomycin 7. Nafcillin |
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Aminoglycosides:
Special Use Agents -Streptomycin: TB -Neomycin: *__1__ prep *Hepatic __2____ *Topical ___3___ -Gentimicin & Tobramycin *0__4___ use |
1. Bowel
2. Encelphalopathy 3. Anibiotics 4. Ophthalmic |
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Aminoglycosides:
Dosing & Serum Levels -Dosing intervals and mg/kg doses are calculated on complicated equations _1__ -Monitor ___2___ levels once steady state is reached -MOST IMPORTANT ARE MONITORING OF __3__ & __4__ LEVELS! |
1. Sawchuk-Zaske
2. serum 3. PEAK 4. TROUGH |
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Aminoglycosides Indications:
3 bacteria Pat gets naked so pat never pees! Amikin: most __4__ reserved for bugs ___5__ to others |
1. Psuedomonas
2. Gram negative Sepis 3. Gram negative pneumonia 4. expensive 5. resistant |