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10 Cards in this Set
- Front
- Back
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AA that make Succinyl CoA:
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TIMV
Threonine Isoleucine Methionine Valine |
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What is Methionine involved in?
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1C pathway and SAM cycle
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How is Methionine made?
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Homocysteine + 1 Carbon unit from N5-methyl-THF makes Methionine
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What enzyme makes Methionine?
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Methionine synthase - uses a cofactor Vit B12
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What happens if Methionine synthase or Vit B12 are deficient?
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Folate is trappd in N5 methyl THF because it's not used for making methionine.
AND Methionine gets degraded. |
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How is Methionine degraded?
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Broken down to Homocysteine, then adds Serine to make Cystathione, then lose Cys to make a-ketobutyrate.
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What happens to a-ketobutyrate?
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Degrades to propionyl CoA then to Succinyl CoA
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What is the USE of methionine?
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Donates Methyl units by a energetic S-adenosyl methionine
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3 things the SAM cycle is used for:
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1. Making methionine
2. Making purines 3. Making dATP (thymidylate synthesis) |
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3 things the 1C folate pathway is used for:
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1. Making phostphatidyl choline from ethanolamine
2. Methylating DNA 3. Making the cap on RNA 4. Making Epi from Norepi |
