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12 Cards in this Set
- Front
- Back
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What is allosteric regulation?
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molecules other than substrate that can bind to sites on enzyme s and activate or inactivate the enzyme.
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What is end-product regulation?
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The final product at the end of a metabolic pathway, feeds back and shuts off the first enzyme in the pathway
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What changes conformation in an enzyme?
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allosteric regulators
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What does positive allosterism do?
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binds regulatory molecule an increases enzyme activity (lower Km or higher Vmax)
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What does negative allosterism do?
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binds regulatory molecules to decrease enzyme activity (higher Km or lower Vmax)
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How are possible mechanisms for enzyme inhibitors determined?
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V vs [S] curves done in the presence of an inhibitor.
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What do competitive inhibitors need to compete?
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higher [S] , can obtain same Vmax with a higher Km
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What happens to noncompetitive inhibitors Vmax? What about noncompetitive Km?
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Vmax decreases however Km is unaffected.
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Where do noncompetitive inhibitors bind?
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sites other than the active (allosteric) site.
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In noncompetitive inhibitors increase in [S] cannot do what?
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overcome inhibition
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What is the key regulatory step for glycolysis and the generation of ATP?
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Regulation
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What are two allosteric activators?
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AMP and ADP.
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