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9 Cards in this Set
- Front
- Back
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What are the 4 types of hypersensitivity reactions? |
Type I: immediate; IgE mediated. Have an acute phase, and then late phase Type II: IgM or IgG Ab bind to fixed tissue antigen (ie BM like Goodpasture, ACh receptor like M gravis Type III: Immune complex. Think vasculitis (serum sickness, arthus reaction) Type IV: delayed type (24-72 hr) Type V: Autoimmune (IgG and stimulatory effect. Think Graves |
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What is the difference between anaphlyaxis and anaphylactoid? |
Anaphylactoid - not IgE mediated. Ie Aspirin, NSAIDs, contrast You cannot clinically distinguish between the two. |
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What is difference between acute and chronic hives? |
Duration ( 6 weeks) For chronic majority is idiopathic. When find a cause, often it is autoimmunity |
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Urticarial Vasculitis |
When Lesions last > 24 hours in a FIXED location - residual ecchymosis, hyperpigmentation Dx: skin biopsy |
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Allergic Rhinitis |
Seasonal (grass, tree, weed pollens) Perennial (dust mites, molds, dander) - nasal congestion, rhinorrhea, sneezing, nasal pruritis - IgE mediated - nasal smear shows eosinophilia PE: Dennie Morgan lines, allergic shiners, "nasal solute" Rx: avoidance, antihistamines, allergen specific immunotherapy |
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When are the following most prevelant? Tree pollen Grass Pollen Weeds |
Tree pollen - spring Grass pollen - early summer Weeds - Fall |
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"NARES" |
Non Allergic Rhinitis with Eosinophilia syndrome -- chronic nasal congestion -- do NOT demonstrate sensitization to any allergens |
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Allergy Immunotherapy |
Only works for IgE mediated conditions -- give increasing dose of allergens via SQ to induce immune tolerance -- also get production of blocking antibodies IgG isotype to IgE |
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"WEMPS" |
Wheat Eggs Milk and Soy Peanuts and tree nuts Seafood -- Most children outgrow hypersensitivity to cow milk, eggs, wheat and soy by 5 y.o -- Allergy to peanuts, tree nuts, shellfish, fish tend to be more permanent. |
