Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
What enzymes metabolise alcohol? |
ALCOHOL DEHYDROGENASE - 75% MIXED FUNCTION OXIDASE - 25% |
|
|
What is alcohol metabolised to? |
ACETALDEHYDE |
|
|
What is acetaldehyde metabolised by? |
ALDEHYDE DEHYDROGENASE - 75% ALDEHYDE OXIDASE - 25% (outside of liver) |
|
|
What effects does alcohol consumption have on the liver acutely? |
Impaired fatty acid metabolism due to alcohol taking up enzymatic resources (+Increased fatty acid release from adipose tissue due to sympathetic stimulation) Causes fatty deposits to build up in the liver Prolonged exposure to toxic aldehyde causes hepatocyte damage and apoptosis |
|
|
How does excessive alcohol consumption cause hepatitis (liver inflammation)? |
Liver becomes overloaded essentially Debris builds up Hepatocytes balloon with excess water and protein Kupffer cells (special liver immune cells) can't deal Neutrophils come in |
|
|
How does alcoholic liver hepatitis progress to cirrhosis? |
Hepatocytes necrose and tissue becomes fibrotic This stage is irreversible |
