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7 Cards in this Set
- Front
- Back
Naltrexone |
-reduce urge to drink, increase control -opiate receptor antagonist -best with psychosocial therapy |
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Acamprostate |
-GABAa agonist -decrease drinking frequency and relapse -normalize dysregulated neurotransmission -can cause diarrhea |
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Disulfiram |
-aversion therapy -inhibit aldehyde dehydrogenase -acetaldehyde syndrome (very pain, get very sick if you drink), common noncompliance |
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Aldehyde dehydrogenase (ALDH) |
-converts acetaldehyde to acetate using NAD+ -acetaldehyde is bad, makes you feel terrible |
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Alcohol dehydrogenase (ADH) |
-converts ethanol to acetaldehyde using NAD+ |
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Microsomal Ethanol-Oxidizing system (MEOS) |
-primarily cytochrome P450 2E1, 1A2, 3A4 -induction by chronic alcohol intake -uses NADPH and O2 -converts ethanol to acetaldehyde |
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Drugs used to treat withdrawal: |
1. Benzodiazepines-- Diazepam and Chlordiazepoxide 2. atenolol - Beta blocker |