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7 Cards in this Set

  • Front
  • Back

Naltrexone

-reduce urge to drink, increase control


-opiate receptor antagonist


-best with psychosocial therapy

Acamprostate

-GABAa agonist


-decrease drinking frequency and relapse


-normalize dysregulated neurotransmission


-can cause diarrhea



Disulfiram

-aversion therapy


-inhibit aldehyde dehydrogenase


-acetaldehyde syndrome (very pain, get very sick if you drink), common noncompliance

Aldehyde dehydrogenase (ALDH)

-converts acetaldehyde to acetate using NAD+


-acetaldehyde is bad, makes you feel terrible

Alcohol dehydrogenase (ADH)

-converts ethanol to acetaldehyde using NAD+

Microsomal Ethanol-Oxidizing system (MEOS)

-primarily cytochrome P450 2E1, 1A2, 3A4


-induction by chronic alcohol intake


-uses NADPH and O2


-converts ethanol to acetaldehyde

Drugs used to treat withdrawal:

1. Benzodiazepines-- Diazepam and Chlordiazepoxide


2. atenolol - Beta blocker