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12 Cards in this Set
- Front
- Back
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nonnucleoside reverse transcriptase inhibitors
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block active site of HIV reverse transcriptase; report RASH
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examples of NNRTIs
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delevirdine (Rescriptor)
efavirenz (Sustiva) - false cannabinoid positive test nevirapine (Viramune) - liver function |
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nucleoside/nucleotide reverse transcriptase inhibitors
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inhibit production of reverse transcriptase and viral replication
report peripheral neuropathy manage N/V diarrhea |
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examples of
NRTIs |
combivir + zidovudine (lamivudine+AZT)
emtriva (Emtricitabine) epivir(Lamivudine) epizicom (abacavir sulfate + lamivudine) hivid (Zalcitabine) zidovudine (Retrovir) trizivir (3) truvada (emtricitabine +tenofovir) videx (Didanosine) viread (tenofovir) zerit (Stavudine) ziagen (Abacavire sulfate) |
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Protease inhibitors
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bind to active site of HIV protease enzyme, interrupt formation of mature viral particles and reduce viral replication
report rash |
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PI examples
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agenerase (Amprevanir)
crixivan (Indinavir) fortovase (saquinavir) invirase (Saquinavir) kaletra (Lopinavir/ritonavir) lexiva (Fosamprenavir) novir (Ritonavir) reyataz (Ataznavir) viracept (Nelfinavir) |
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Fusion inhibitors
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block HIV-1 fusion with CD4+ cells to prevent entry
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Fusion inhibitor example
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enfuviritide (Fuzeon), watch for hypersensitivity rx
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what HIV drugs do: overview
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prevent virus from attaching to CD4+ receptor
interfere with uncoating of virus in cell inhibit reverse transcriptase prevent changing RNA to DNA inhibit protease - needed for protein adherence prevent viral assemly/budding of the cell |
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HAART therapy
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highly active retroviral therapy
cocktails to reduce drug resistance, but must strictly adhere to therapy |
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integrase inhibitors
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new class
prevents integration of viral DNA into cell chromosone, cell cannot be infected |
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S&S of opportunistic infections
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new fever high than 100 degrees F, change in pattern of low grade
cough, SOB, fever, chest tight' CNS infection (headache, stiff neck, vision changes, balance) foul smelling drainage/pus cloudy/foul smelling urine dehydration rashes sore mouth/tongue, white patches, difficulty swallowing worsening fatigue changes in vision/floaters |
