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19 Cards in this Set
- Front
- Back
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What age does hutchinson gilford show up at?
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25 years
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what are the symptoms of hutchinson gilford?
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skin atrophy, hair loss, loss of subcutaneous fat, arteriosclerosis
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what is the associated gene of hutchinson gilford?
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nuclear lamin a/c
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what age does werner show up at?
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60 years
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what gene does it involve?
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wrn
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what are the symptoms?
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skin atrophy, cataracts, hypogonadism, etc.
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what is the gene associated with cockayne type a?
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ckn1
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what is the gene associated with cockayne type 2?
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ercc6
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what are the symptoms of cockayne?
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neurogeneration, cataracts, photosensitivity, hypogonadism
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what is the age of cockayne?
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40
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what is the gene associated with ataxia telangectasia?
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atm
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what is the age of ataxia telangectasia?
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45 years
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what are the symptoms?
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cerebellar, hypogonadism, cancer,
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what are the 4 aspects of principalism?
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autonomy, beneficence, nonmalificence, justice
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what are the results of consequentialism?
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relativism, casuistry, geocultural
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how does caloric restriction improve aging?
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reduces insulin, reduces damage from ROS, delays reproduction
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Lean body mass declines with age. Drug distribution, tissue concentrations and serum concentration will be increased for which of the following:
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lipophilic compounds
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Binding proteins will change with age. Albumin decreases with age as well as concomitant disease. Which of the following medications would most likely have clinically significant changes in their pharmacological action as a result of decreased albumin?
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phenytoin
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What is beers criteria?
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Drugs with high anticholinergic action: amitryptyline, doxepin, diphenhydramine, hydroxyzine
Long acting benzos:diazepam, flurazepam, chlordiazepoxide Pentazocine: CNS effects Propxyphene: lack of effectiveness |
