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41 Cards in this Set
- Front
- Back
Give an example of a self-regulated system where the drug is delvered automatically in response to a bio need.
~think diabetes~ |
Glucose-responsive insulin delivery.
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A therapeutic systems approach to optimized the timing and location of drug delivery is called____________
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Advanced drug delivery
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What are three potential targets for drugs?
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Tissue site
Cell Intracellular |
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Which of the following are characterisitics of an ideal drug delivery system?
a. Drug is delivered systemically b. Drug is delivered to the site of action c.Proper timing of drug d.Drug is given for extended periods of time. e. both b&c f. all of the above |
e. B&C
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What controsl the rateof drug release from the system in advanced drug delivery?
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Polymers (drugs travel through the pores)
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Match the terms witht their definitions.
1. Flux 2. Area 3, Length 4. Concentration difference a.concentration gradient across the polymer b.polymer thickness c.are in contact wit the environment( patch size) d.rate of transport through polymer |
1.d
2.c. 3.b 4.a |
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What are three Temporal control (Time release) methods of drug delivery?
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Depot injectibles (SC or IM)
Implants Infusion pumps |
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For Depot injections, prodrugs are usually:
a.hyrdophillic b. lipophillic c. hydrophobic d. lipophobic |
b. lipophillic
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What is the advantage of the prodrug (in depot injections)being lipophillic?
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Leads to slow paritioning form oil fo rfat to interstitial fluid.
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Vaccines bound to aluminum hydroxide gel that slowly release antigen are what type of binding:
a. suspensions b.prodrugs c. biinding to adsorbents |
c. binding to adsorbents
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Bioerodible microspheres act as ________ __________ systesm to prolong drug releast.
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bioerodible matrix
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Which of the following are types of implants?
a. polymer b.mechanical c. osmotic. d. all of the above |
d. all of the above.
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What type of implants require surgical insertiona and reoval?
a. polymer b. mechanical c. osmotic |
.a. polymer
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Which order release is described as where diffusion froma saturated solution is controlled by polymer membrane?
a. polymer b.mechanical c.osmotic |
polymer
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Give two examples of histrelin acetate implants
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Suprellan LA
Vantas |
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Which histrelin acetate implants are used for central precocious puberty?
a. Suprellan LA b. Vantas |
Suprellen LA
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Which Histrelin acetate implants are used for the palliative treatment of prostate cancer?
Suprellan LA Vantas |
Vantas
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T/F Suprellan LA and Vantas differ in their delivery rates
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T
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Implan can be used for up to ____years
a. 1 year b. 6 months c. 3 years |
c. 3 years
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Histrelin acetate implants have ________ release from membrane, followed by ______ year(s) of steady release
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immediate, one year
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T/F Mebrane controlled ( Reservoir) polymer imppnats do not need to be surgically removed.
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F
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T/F Bioerodible matrix impnats muse be removed
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F. DONOT have to be removed
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Zoladex is an example of a _______ _______ implant that is inserted SC in the _________ and whose polymer slowly breaks apart and relase the drug when ______ penetrates and hydrolyzes it.
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bioerodible matrix; abd; water
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How long is Zoladex used for?
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1-3 months
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A _________ implant of Carmustine is homogenously dispersed in a bioerodible polymer matrix. This is also called a _________wafer.
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intracranial; Gliadel wafer
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What are the three types of Bioerodible matrix implants?
G. E. Z |
Gliadel wafer, Eligard, Zoladex
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What is GLIADEL wafer composed of?
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microspheres compressed into a disc
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What are two effects of the wafer compositionin a gliadel wafer?
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1. Polymer degrades at the surface to release drug slowly
3. Protects from degradation |
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Which bioerodible matrix implant is injected as a liquid and becomes a solid when tissue water causes the polymer to ppt and trap the drug in the solid implant?
a. Eligard b. Gliadel c. Zoladex |
a. Eligard
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Mechanical implant infusion pumps use _________ pressure to deliver the meds
a. negative b. positive c.no |
b. positive
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What are two good characteristices of Mechanical implants( implantable fusion pumps)
(think the type of metal it is made with and what is its used for) |
1.They are made with Titatnium which is biocompatible
2. They can be used for both spatial and temporal control of drug deliver |
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Which of the following are included in an implantable fusion pump:
a. pumping mechanism b. drug resevoir c.catheter d. iv piggy back e. all of the above |
a, b ,c
(Drug reservoir, catheter, pumping mechanism) |
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Synchromed and Minimed are example of __________ _______ mechanical implants
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Bioerodible matrix
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SynchroMed works by the drug solution being pumped from a reservoir into a _________ by a ________ mechanisim via rotating cams.
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catheter, peristalic
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This Mechanical implant uses a piston to force fluid out
a. MiniMEd b. Synchromed |
a. MiniMed
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How are some implants programmed externally for constatn infusion or according to circadian rhythms?
a. Teleakinesis b.telemetry c.manual |
b. Telemetry
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T/F Similiar to infusion pumps, ambulatory infusion pumps use positive pressure.
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T
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Ambulatory infusion pumps allow patients to deliver their own pain med via __________, but also ________.
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IV, Epidural
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Which of the following is not a therapeutic application of Amb infusion pumps?
a. Cancer chemo b. Antimicrobials and TPN c. PCA d. all of the above e. Insulin |
d. all of the above
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This type of amb infusion pump can be considered an artifical pancreas.
a. Minimed b. Synchromed c. Nipro d. Animas |
c. Minimed
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What two types of products are thought to offer some spatial control of parenteral drug delivery?
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1. Liposomes
2. Albumin nano particles |