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9 Cards in this Set
- Front
- Back
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A |
Augmented drugs e.g. antiPLTs, diuretics, NSAIDs augmentation of 2ary pharmacology as well as 1ary e.g. gastric irritation with aspirin (as well as bleeding), tachycardia with salbutamol e.g. fluconazole interacts with warfarin => GI bleed in pt on prednisolone (which causes GI irritation) e.g. warfarin => SDH 2ary to fall --> confusion |
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B |
Bizarre often immune-mediated e.g. penicillin allergic rxn (Tx with IM adrenaline) |
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C |
Continuing = rxns persist after discontinuation e.g. bisphosphonates => jaw osteonecrosis |
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D |
Delayed e.g. carbimazole => agranulocytosis e.g. typical antipsychotics => tardive dyskinesia e.g. chemo => infertility e.g. thalidomide => phocomelia |
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E |
End-of-use = rxns ass with withdrawal e.g. BZDs => agitation/insomnia e.g. opiates => flu-like S |
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Tx for ADR? |
stop drug supportive care specific Tx document ADR - Yellow Card - sent to MHRA |
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warfarin ADRs: which drugs = CYP2C9 inhibitors and TF augment warfarin activity? |
fluconazole ketoconazole amiodarone efavirenz fluvastatin |
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warfarin ADRs:which drugs = CYP2C9 inducers and TF inhibit warfarin activity? |
carbamazepine phenobarbitol phenytoin rifampicin |
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how can NSAIDs induce heart failure and DIB? |
2x mechs: decreased PG means reduced GFR and salt/fluid retention --> peripheral oedema increased leukotrienes => bronchoconstriction => DIB |
