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22 Cards in this Set
- Front
- Back
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alpha 1 receptors:
-location -response -exception to normal response |
-smooth muscle
-generally elicit contraction -relax smooth muscles of GI tract (inhibits) and erectile tissues (vascular engorgement) |
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beta 1 receptors:
-location -reponse |
-heart and adipose tissue
-stimulate excitatory activity -increase cardiac rate and contractility, lipolysis |
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beta 2 receptors
-location -function |
-bronchioles, intestines, euterus, arterioles of muscles
-stimulates smooth muscle to relax, vasodilation |
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DA1 receptors:
-function |
-stimulate vasodilation of renal and mesenteric arteries (increase blood flow)
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which receptors are more sensitive to epi - alpha or beta
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-beta 1 and 2 are 10x more sensitive to epi
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What is the major NT of the sympathetic nervous system
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-norepinephrine (levarterenol, levophed)
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In what two ways in NE released
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-released into synapse following activaiton
-released as circulating hormone by adrenal gland |
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What triggers release of epi from adrenal medulla
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-impulses from greater splanchnic nerves (nicotinic agonist)
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What is the major NT of the CNS
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-dopamine
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What two things does dopamine do that helps when used to treat shock
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-promotes myocardial contractility and kidney function
-decreases metabolite build up |
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Isoproterenol
-what is it -what it does -uses |
-synthetic catecholamine
-stimulates B1 and B2 receptors equally -bradycardia, control of airway in inhaler form (asthma, COPD) |
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How does epi affect blood pressure
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-systolic increases due to B1 effects on heart
-diastolic decreases due to vasodilation of skeletal muscle (b2) |
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How does norepi affect blood pressure
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-diastolic and systolic increased
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What is the effect of the vagal reflex
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-to slow the heart
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How can epi decrease MAP
-how can it increase MAP |
-by B2 --> skeletal muscle vasodilation
-by B1 -- > myocardial stimulation a1 --> vasoconstriction of many vascular beds |
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T/F - NE has no vasodilator (B2) activity
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-true, only epi does
-decreased heart rate, increased MAP |
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Which catecholamine causes an increase in MAP
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-NE
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Adrenoceptor agonists:
substitute amino group substitute benzene ring substitute alpha carbon |
-increase potency, isoproterenol, dobutamine, terbutaline
-decreased potency, increased duration; metaraminol, phenylephrine, ephedrine -block MAO activity, prolonged activity; metaraminol, ephedrine |
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What adrenergic agonist is useful to treat CHF
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-dobutamine
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Metaproterenol, terbutaline, albuterol
-what -uses |
-B2 selective adrenergic agonist
-bronchial asthma |
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What adrenergic agonist is sued to elicit mydriasis for an eye exam
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-phenylephrine
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Which drug for:
anaphylactic shock hypovolemic shock cardiogenic shock |
-epi
-dopamine -dobutamine (B1 preference) |
