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27 Cards in this Set
- Front
- Back
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What is an adrenergic receptor?
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Why, they are a class of G-protein receptors targeted by catecholamines (epinephrine and norepinephrine) but NOT dopamine. The ones we need to know are alpha-1, alpha-2, beta 1-3. These are part of the sympathetic nervous system of the autonomic nervous system.
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General function of A1
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excitatory
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General function of B2
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inhibitory
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General function of A2
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digestive system
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General function of B1
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cardiac
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General function of A3
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Adipose tissue and kidney only
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Where are adrenergic receptors located?
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effector organs and glands of the sympathetic nervous system
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Where are the ganglia of parasympathetic system located?
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In tissues and effector organs
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Receptor for parasympathetic nervous system
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mACh
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Where are mACh receptors located?
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effector organs of parasympathetic system
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Acetylcholine
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the only NT released by parasympathetic nervous system
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Catecholamines (Para or Symp?)
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Epinephrine or Norepinephrine
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Where are the ganglia of SYMPATHETIC system located?
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on the spinal cord
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Where are nACh receptors located?
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in ganglion of both para and sympathetic nervous system and skeletal muscle
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Dilation of arteriole of skeletal muscle
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Para - mAChR
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What is the only NT released by PS system?
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Acetylcholine
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ACh on intestinal muscles (E or I)
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excitation
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exogenous ACh on mACh (E or I)
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excitation
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ACh on parasympathetic ganglia (E or I)
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excitation
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Sympathetic Action on Heart: Epi or NE? Which receptor? Effect?
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Norepinephrine
Beta-1 Increase HR and Contraction |
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Intestinal Blood Flow
Para action Symp: NT/Receptor/Action |
Para: dilation -> digestion
Symp: NE; A1 (excitatory-excite muscle cell); contraction -> less blood flow |
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ACh on Blood flow: (Para and Symp) (COMPLICATED)
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Symp: Dilation of vessels -> Increase blood flow -> B2
Para: heart rate decrease therefore decrease in blood flow of total system |
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ACh on Pupils (Dual innervation)
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sphincter (circular) muscles activated by ACh acting on mAChR. --> constriction. Radial muscles are activated by NE to dilate.
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Effects of Muscarine (belladonna extract)
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competitive ligand for ACh on mAChR -> dilation of pupils due to relaxation of sphincter muscles.
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Heart Rate and Force
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Parasympathetic: relaxation (slows heart rate)
Sympathetic: B1 (speeds up) |
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Where are nACh receptors located?
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Skeletal muscle, ganglion of tissue and on spinal cord
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where are adrenergic receptors located?
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in effector organs
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