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6 Cards in this Set
- Front
- Back
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Phenylephrine |
WHAT? a1 selective adrenergic agonist, direct sympathomimetic MOA? Activation of PLC/ Inositol pathway. Leading to release of intracellular Ca2+. EFFECTS? All smooth muscle excpet that in the G.I contract in responce to stimulation of a-1 receptors due to Ca2+ release.Large arteries and veins and also arterioles are constricted, decreased vascular compliance, increased peripheral resistance (increased BP)a-1 receptors stimulate smooth muscle proiferaction in blood vessels and prostate. This is important in benigh prostatic hyperplasia (treated with a-1 antagonists) USES? Nasal decongestant |
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Dobutamine |
WHAT? B1 selective agonist, sympathomimetic. MOA? Agonises B1 adrenoceptors in the heart, increase in HR and contraction force USES? Cardiac failure |
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Clonidine |
WHAT? Selective a2 adrenoceptor agonist, direct sympathomimetic MOA? Decrease in Adenyly cyclase activation, decrease in cAMP and Ca2+ channel activation and phosphorylation. Inhibitory effect EFFECTS? Nerve terminals:Presynpaptic adrenoreceptors present on both cholinergic and NA nerve terminals. Inhibitory action due to a-2 actionMetabolism: Inhibition of insulin secretion due to a-2, leads to adrenaline-induced hyperglyceamia USES? |
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Salbutamol, talbutaline, sulmeterol |
WHAT? B2 selective agonist, sympathomimetic MOA?Agonises B2 adrenoceptors on smooth muscle, increase of cAMP leafs to increase of Ca2+ extrusion and reuptake. EFFECT? Relaxation of smooth muscle and vasodilation of vascular beds. USES? Asthma (reversible obstructive pulmonary disorders) Relaxion of the uterus to delay premature labour |
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Nor-Adrenaline and Adrenaline |
WHAT? Sympathetic transmitters MOA? Non selective agonist of a and B adrenoceptors EFFECT? Sympathetic activation USES? NA; Transmitter at postganglionic neurons of the sympathetic system and in the CNS. Sometimes used for hypotension in intensive care A; Main hormone of the adrenal medullaTreats asthma in emergency treatmentAnaphylactic shockCardiac shock |
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Prazosin |
WHAT? a1 selective antagonist. Similar drugs with longer half lives are better e.gDoxazosinTerazosin MOA? Inhibition of a1 receptors EFFECT?VasodilationFall in arterial pressureRelaxation of smooth muscle of bladder neck and prostate capsuleInhibit smooth muscle hypertrophy USES?Hypertension |
