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34 Cards in this Set

  • Front
  • Back
Metyrosine
Blocks NE synthesis
Reserpine
Blocks NE storage
Guanethidine
Prevents NE release
Tyramine
Promotes NE release
Amphetamine
Promotes NE release
Cocaine
Inhibits reuptake of NE
Tricyclic antidepressants
Inhibit reuptake of NE
MAO Inhibitors
Prevent metabolism of NE
Epinephrine
Activates A1 and A2 receptors
Prazosin
Blocks A1 receptors
Yohimbine
blocks A2 receptors
Dobutamine
Activates B1 receptors
Metoprolol
Blocks B1 receptors
Albuterol
Activates B2 receptors
Butoxamine
Blocks B2 receptors
Activation of B1 in the heart
Increase in SA node rhythm
Increase in all parameters for atrium, AV node, and ventricle, except decrease in refractoriness
Activation of B1 in the kidney
Increased renin secretion
Activation of B2 in skeletal muscle
Dilation of blood vessels (arterioles)
Increased Ca sequestration
Increased K uptake
Activation of B2 in liver
Dilation of blood vessels (arterioles)
Increased glycogenolysis
Increased gluconeogenesis
Relaxation of gallbladder, ducts
Activation of B2 in the lungs
relaxation of bronchial smooth muscle
Activation of B2 in mast cell, basophils
Inhibition of degranulation
Activation of B2 in the uterus (pregnant and non)
Relaxation
Activation of B2 in the bladder
decreased motility and tone
Activation of B3 in fat cells
Increased lipolysis
Activation of a1 on arterioles of organs
constriction
Activation of a1 in skin
constriction of blood vessels,
pilomotor muscle contraction, thick secretion from apocrine sweat glands
Activation of a1 on sphincters of GI tract
constriction
Activation of a1 on vas deferens, seminal vesicles, and prostate
ejaculation
activation of a1 on radial muscle of eye
contraction
activation of a2 on platelets
aggregation
activation of a2 on pancreatic b-cells
decreased insulin secretion
activation of B2 on ciliary epithelium
increased aqueous humor production
activation of a2 on ciliary epithelium
decreased aqueous humor production
activation of a2 on presynaptic nerve terminals on preganglionic ANS neurons
decreased NE and Ach release