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34 Cards in this Set
- Front
- Back
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epinephrine
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a1,2,b1,b2 (B's MORE)
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NE
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a1,2 (b1 MOST)
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isoproternol
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b1,b2
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oxymetazoline
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a1,a2
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terbutaline
albuterol salmerterol |
b2
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dobutamin
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b1
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clonidine
apraclonidine |
a2
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phenylephrine
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a1
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release agents
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amphetamine
tyramine |
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uptake inhibitor
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cocaine
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mao/comt inhibitor
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paragyline
entacapone |
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mix-acting
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ephedeine
all of the receptors + Releasing agent |
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dopamine
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D1, d2
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b1,b2,b3 mechanism?
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gs (cAMP increase)
L type ca+2 channels |
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a1 mechanism
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Gq (phospolipase C, Ca+2 channels)
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a2 mechanism
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Gi (cAMP decrease, K+ increase, PLC incease)
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EPI pharmokinetics
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0% oral bioavail
no CNS metabolized by liver (MAO/COMT) 2 min t1/2 IM faster absorbtion |
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USES OF EPI
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acute hypersenitivity (anaphyalaxi/angioedema)
surgical bleeding open angle glaucoma (decrease pressure) cardiopulm resus/ cardiac arrest (a1 activation, reduce BF to renal...back to heart) |
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NE
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causes BRADYcARDIA (w/ baroreflex)
vasodialation on all conornay/pulm vessels use with HYPOTENSION & VASODILATRY SHOCK (sepsis, spinal anethesisa, spinal trauma) - use with local anestehesis (to slow absorbtion) |
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Dopamine
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LD d1 receptor (vasodilation/renal, stop Na+ resorb in prox tub)
ID b1 + release of NE (SV and HR UP) HD a1 + D2 (area postrema) (increase sys vasc resistance, vomiting/nausea) ALL UNDERGO TOLERANCE DOES NOT ENTER BRAIN/not active oral t1/2 = 2mins IV only USES - cardiogenic/neurogenic/spetic shock (cuz poor renal perfusion) |
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Phenlephirine
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a1 (selective)
not inact by COMT adverse affects hyperten, photophobia USES hypotension, nasal decongest, myrdiatics, local vasoconstricters |
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a2 drugs...control
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presyn nerve terminal control NE release
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Clondine/apraclonidine
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a2 selective
ativates Nucles of Tractus solatarious & rostal ventrolateral medulla activates Imidazoline receptors all leads to Decreased firing of reticulospinal tract (central adernergic tone) Effects..... hypotension (LD) high does HYPERTENSION (a1/a2 activated) craving reducing affects, sedative, anaglesic Decease intraoc pressure (dec aq humor) increase absorb of fluid in intesttine USES hypertension open angle glaucoma (apraclonaine) hot flashes, ADD, autism, tourettes |
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Dobutamine
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B1 selective
heart - increase conttract/condction not active by oral. t1/2 = 2mins uses - given by IV with severaly depressed left Venct fucntion |
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albuterol/salmerterol/terbutaline
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b2
resp- broncodialation, mucus clearance, supression of inflam mediators (hist/leukotiries) reduce microvasc perm oral bioval (first pass maybe high) BBB limited t1/2 - 1 to 14 hours INHALINATION main route |
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B2 agonist time lasting
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1.5 hours (EPI, isoprotenol)
3-6 hours (albuterol) >12 hours (salmeterol/formoterol) |
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B2 adverse affects
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CNS - tremors/cramps/restlessness
Cardio - tachycardia, hypotension Resp - hypoxemia (too much dialation, decrease V/Q ratio, paradox broncoconstiction Othersystems - hypokalemai, stimulates K+ into cells hyperglycemia |
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b2 contraindiactions
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don't use in eldery
hyperthyroidism seizures |
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b2 theraputic uses
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asthma (as needed)
COPD premature LABOR (defer delivey) hyperkalemia (puts K+ in cells) |
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Tyramine
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Indirect acting
taken up by neurons - changed to octopamine....displaces NE inactive due to large first pass (oral) Adverse affects bad with MAO inhibitor (leathal hypertensive crisis, due to NE release) USE - localize lesion of symp nerves |
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Methyldopa
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taken up by neurons....hcanged to methlyNE...a2 agonist (similar to clondine)
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Amphetamines
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stimulate release of NE, dope, Seroton
blocks catecholamine reuptake elevation of mood/euphoria (CNS) similar to NE in periper uses - ADD, hyperact disorder/narcolepsy/wt reduction |
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cocaine
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blocks cat reuptake
local ansesteia perip - same as NE CNS - similar to amph...more intest/shorter |
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ephedrine
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actives all receptors (adernergic)
enhances release of NE similar to NE lower potency longer duraction oral activiy ADverse affects - Restlessness/insomnia/urinary rention clincial - nasal decongestant |
