Adrenergic Drugs

Front 1

List the SNS neurotransmitters

Back 1

NE, 5HT, DA,

Front 2

List excitatory messengers

Back 2

SNS neurotransmitters (NE, DA, 5HT)
CNS neurotransmitters: glutamate, NMDA
Hormones: Epi
Polypeptides: CCK, Substance P, Neuropeptide Y
Opiods: Beta endorphins, Enkephalins, Dinorphins
Endocannaboids

Front 3

MAO's vs Catecholamines

Back 3

MAO's= 5HT, NE, DA "SND"

catecholamines= Epi, NE, DA "END"

Front 4

COMT inh
MOA:
uses:
S/E:

Back 4

MOA: inh COMT from breaking down catecholamenis "END" in the postganglion
uses: Parkinsons
S/E: ???

Front 5

List 5HT agonists

Back 5

1) Cisapride
2) Methysergide
3) Metachlopromide
4) Sumatriptan

Front 6

Cisapride
MOA:
uses:
S/E:

Back 6

MOA: 5HT agonist
uses: GERD, delayed gastric emptying (seen in DM, post surgery)
S/E: Torsades, blocks p450 ****pulled off market

Front 7

Methysergide
MOA:
uses:
S/E:

Back 7

MOA: 5HT agonist
uses: migraines
S/E: MI, strokes, retroperitineal fibrosis *****pulled off market

Front 8

Metachlopramide
MOA:
uses:
S/E:

Back 8

MOA: 5HT agonist, DA blocker
uses: GERD, Delayed gastric emptying (seen in DM and post surgery)
S/E: Parkinsons- like sx's
*****pulled off market

Front 9

Sumatriptan
MOA:
uses:
S/E:
CI:

Back 9

MOA: 5HT agonist
uses: DOC for migraines

S/E: coronary vasospasm
CI: CADz, Prinzmetels angina, preg

Front 10

alpha 2 rec locations and stimulation

Back 10

1) CNS: dec sympathetics
2) beta cells: dec insulin secretion

Front 11

dynamics of
1) Epi
2) NE
3) DA

Back 11

1) Epi: beta > alpha (low doses)
alpha > beta (high doses)

2) NE: alpha1, 2 > beta 1 (does not de beta 2)

3) DA: D2 at low dose (perfuse kidney)
Beta 1 at med dose (inc contractility)
alpha 1 at high dose (vasoconstrict)
*reverse from alphabetical order, D-->B-->A

Front 12

rec and 2nd messenger for
1) alpha 1
2) alpha 2
3) beta 1
4) beta 2
5) D1
6) D2

Back 12

1) Gq: IP3/DAG
2) Gi: dec cAMP
3) Gs: inc cAMP
4) Gs: inc cAMP
5) Gs: inc cAMP
6) Gi: dec cAMP

Front 13

locations and stimulation of alpha 1 rec

Back 13

1) sphincter: tighten
2) arteries/veins : constrict
3) eye radial musc: mydriasis w/o cycloplegia

Front 14

Epi
uses:
clue:

Back 14

uses: DOC for anaphylaxis and DOC for Vfib

clue: short 1/2 life (2hrs), bad rebound

Front 15

Which drug causes rhinitis medicamentosa?

Back 15

Epi

Front 16

NE:
uses:

Back 16

uses: DOC for septic shock

Front 17

DA
uses

Dobutamine uses

Back 17

????

Front 18

name 2 alpha 1 agonists

Back 18

1) Pseudoephedrine
2) Phenylephrine

Front 19

Phenylephrine
MOA:
uses:

Back 19

MOA: alpha 1 agonist
uses: decongestion, DOC for neurogenic shock

Front 20

Name 4 alpha 1 blockers

uses
S/E:

Back 20

1) Parazosin- HTN only
2) Terazosin- bph 1st line
3) Doxazosin- bph 1st line`
4) Tamsusolin- bph 2nd line

S/E: 1st dose hypOtension

Front 21

DOC for BPH
MOA:

2nd line for BPH
MOA

Back 21

DOC: Terazosin and Doxazosin
MOA: alpha 1 blocker

2nd line: Tamsusolin
MOA: alpha 1 blocker

Front 22

Parazosin
MOA
uses
S/E:

Back 22

MOA: alpha 1 blocker
uses: HTN
S/E: 1st dose syncope (take at night)

Front 23

Name 3 alpha 2 agonists

Back 23

1) Clonidine
2) alpha methyldopa
3) guanabenz

Front 24

Clonidine
MOA
uses
S/E

Back 24

MOA: alpah 2 agonist (alpha 2 rec only found in CNS- thats why it drops BP)
uses: HTN, tourettes, menopause sx's
S/E: rebound HTN if stopped quickly

Front 25

alpha methyldopa
MOA:
uses:
S/E:

Back 25

MOA: alpha 2 agonist (alpha 2 rec only see in CNS- thats why it drops BP)
uses: DOC for HTN in preggos
S/E: hemolytic anemia, rebound HTN if stopped quickly

Front 26

Name 3 alpha 2 blockers

Back 26

1) Yohimbine
2) Mirtazapine
3) Tolazoline

Front 27

Yohimbine
MOA:
uses:

Back 27

MOA: alpha 2 blocker
uses: impotence (allows you to "shoot")

Front 28

Mirtazapine
MOA
uses:

Back 28

MOA: alpha 2 blocker
uses: depression
S/E: sedation, inc cholesterol, inc appetite

Front 29

Tolazoline
MOA:
uses:

Back 29

MOA: alpha 2 blocker
uses: RDS in premies

Front 30

Name 2 nonselective alpha blockers

Back 30

phentolamine, phenoxybenzine,

Front 31

Epi/NE reversal

Back 31

nonselective alpha blockers
(phentolamine, phenoxybenzine)

Front 32

Phentolamine
MOA:
uses:

Back 32

MOA: nonselective alpha blocker; short acting
uses: dx pheo, HTN in cocaine users

Front 33

Phenoxybenzamine
MOA:
uses:

Back 33

MOA: nonselective alpha blocker; long acting
uses: rx carcinoid, rx pheochromocytoma

Front 34

Dobutamine
MOA:
uses:
effects on HR, contractility, BP

Back 34

MOA: beta-1 agonist
****the only one

uses: cardiogenic shock, CHF
inc HR, inc contractility, no affect on BP

Front 35

Name the Beta 2 agonists

Back 35

1) Formoterol
2) Albuterol
3) Ritodrine
4) Terbutaline
5) Salmeterol

"FARTS"

Front 36

Name the 3 nonselective beta agonists

(which still have a little more beta 2 affinity than beta 1)

Back 36

1) Metaproteronol
2) Isoproteronol
3) Levoproteronol

"MIL"

Front 37

Name the 3 beta-nonselective blockers

Back 37

1) Timolol
2) Prapanolol
3) Nadolol

"TPN"
"N-Z, C&L"

Front 38

Which beta rec working drugs can be used to bronchodilate?

Back 38

1) Formoterol- beta 2 agonist
2) Albuterol- beta 2 agonist
3) Terbutaline- beta 2 agonist
4) Salmeterol- beta 2 agonist
5) metaproterenol- ns beta agonist

F and S are long lasting (BID)

Front 39

which beta rec working drugs can be used to treat glaucoma?

How do they help?

Back 39

1) butexolol- beta 1 blocker
2) timolol- ns beta blocker
3) nadolol- ns beta blocker

-dec production of aqueous humor

Front 40

Which beta rec working drugs can be used to delay preterm labor?

Back 40

1) Ritodrine- beta 2 agonists
2) Terbutaline- beta 2 agonists

Front 41

Which beta rec working drug do we use to treat thyroid storm?

Back 41

Esmolol- short acting beta 1 blocker

Front 42

Labetalol
MOA
uses

Back 42

MOA: blocks alpha1, beta 1, beta 2 equally
"a nonselective beta blocker that also blocks alpha 1"

uses: Afib, HTN crisis (preggo, dissection, pheo)

Front 43

Carvedilol
MOA
uses

Back 43

MOA: blocks alpha 1, beta 1, beta 2 equally
"a non-selective beta that also blocks alpha 1"

uses: HTN crisis (preggos, dissection, pheo), chronic CHF

Front 44

Name 2 drugs that release stored catecholamineds

Back 44

1) Amphetamines
2) Ephedrine

Front 45

Amphetamine
MOA
uses

Back 45

MOA: releases stored catecholamines
uses: obesity, ADHD, narcolepsy

Front 46

Ephedrine
MOA
uses

Back 46

MOA: releases stored catecholamines
uses: decongestant, urinary incontinence, hypOtension

Front 47

Cocaine
MOA
uses

Back 47

MOA: catecholamine uptake inh
uses: nose surgeries

Front 48

DOC for stress incontinince

Back 48

Pseudoephedrine
(alpha 1 agonist)