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16 Cards in this Set

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Reserpine
Blocks Mg-ATPase
Adrenergic blocking drug
NE can't enter vesicle, broken down by MAO
Lowers BP, NO tachycardia
SEVERE depression / H suicide
Blocks __________ in the presynaptic vesicle
Guanethidine
Displaces NE from ATP within the NE vesicle in the presynaptic vesicle
IV/IM short duration
Lowers BP
Causes severe diarrhea
Displacement
Guanedrel
Displaces NE from the ATP in the NE vesicles
Longer duration of action than Guanethidine
Lowers BP
Severe diarrhea
Displacement - similar to Guanethidine
Metyrosine
NE-Met replaces the real NE in the vesicle making the process entirely useless. No NE released
Lowers BP
FAST TOLERANCE - ONLY 1 DAY
False neurotransmitter
Phentolamine
NON-SPECIFIC drug
Causes vasodilation of BV
Releases histamine
Contraindicated in patients with decreased coronary perfusion
Can trigger arrhythmia, anginal pain
Vasodilator
Phenoxybenzamine
Irreversible and noncompetitive non-specific alpha blocker
Causes slight tachycardia
Not good for lowering BP
Used to control bladder
Non specific drug - raise in heart rate (slight tachycardia)
Prazosin
Specific alpha blocker
Used to lower blood pressure
First pass effect - syncope
Long duration of action
May cause dizziness/ fainiting/ drop in BP
Syncope
Specific alpha blocker
Doxazosin
Same as Prazosin
No first pass effect
Decreases BP
Longer duration of action than Prazosin
Same as Prazosin
Tamulosin
Specific alpha blocker
Not used to lower blood pressure
shrinks the prostate
Longer duration of action than either Doxazosin and Prazosin
Atenolol
Specific beta blocker
Beta 1 blocker
Lipid soluble
Slow metabolism
12-24 h half life
NO MSA
Esmolol
Moderate lipid solubility
Moderate plasma protein building
30-60 seconds half life
NO ISA
beta blocker
Low MSA
Fast metabolism
Metorpolol
May cause insomnia
Used to treat High BP
Moderate lipid solubility
Moderate plasma binding protein
beta blocker
Nadolol
Non - specific beta blocker
Moderate lipid solubility
Moderate plasma binding protein
24 h half life
NO ISA
NO MSA
Pindolol
Used in high BP
Only drug that has a HIGH ISA
Beta blocker
Propanolol
Beta blocker
Non-specific drug
HIGHEST LIPID SOLUBILITY
CAUSES INSOMNIA
HIGH MSA
Moderate plasma binding protein
elimination half life 12 h
Low ISA
Moderate metabolism
Timolol
beta blocker
Non- specific selectivity
Moderate Lipid solubility
Used as eye drops
6 h half life
Reduces production of aqueous humor in eye
Used topically in treatment of chronic open-angle glaucoma
Occasionally for treatment of BP
Moderate metabolism