Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
actions of alpha blockers
|
- act on peripheral resistance w/o affecting CO
- all decrease BP - reflex tachycardia - induce orthostatic hypotension |
|
|
phenoxybenzamine
|
- alpha1, alpha2 blocker
- irreversible, noncompetitive - tx pheochromocytoma, raynaud's syndrome - CI: if poor coronary perfusion |
|
|
phentolamine
|
- alpha1, alpha2 blocker
- competitive, reversible - diagnose pheochromocytoma - CI: if poor coronary perfusion |
|
|
prazosin, terazosin, doxazosin
|
- selective alpha1 antagonists
- tx HTN, benign prostatic hyperplasia - decreases vascular tone of veins AND arteries - vasodilation |
|
|
yohimbine
|
- alpha2 antagonist
- tx impotence |
|
|
actions of beta blockers
|
- all are competitive antagonists
- all decrease BP by decreasing CO & renin production - increase cholesterol over time |
|
|
propanolol
|
- beta1, beta2 blocker
- tx HTN, migraine, arrhythmia, termor & thyrotoxicosis, angina - CI: HF, asthma |
|
|
timolol & nadolol
|
- beta1, beta2 blocker
- tx POAG - decreases aqueous production (the first one) - both more potent than propanolol - CI: HF, asthma/respiratory disease (blocks beta2 100%) |
|
|
batazolol
|
- selective beta1 blocker
- tx glaucoma; less potent decrease in IOP than timolol |
|
|
acebutolol, atenolol, metoprolol, esmolol
|
- selective beta1 antagonists
- decrease BP, tx CV disease, diabetic HTN |
|
|
pindolol & acebutolol
|
- partial agonist activity
- intrinsic sympathomimetic activity - DONT increase cholesterol - tx HTN in pts w/high cholesterol or bradycardia (cant have full blown beta blockers) |
|
|
labetolol
|
- mixed antagonist activity
- alpha(1) AND beta(1,2) blocker - peripheral vasodilation - tx HTN in the elderly, african americans - tx pregnancy-induced HTN |
|
|
reserpine
|
- inhibits NE packaging into vesicles
- decreases sympathetic outflow everywhere in the body - receptors become hypersensitive |
|
|
guanethidine, bretylium
|
- blocks NE release
|
|
|
imipramine, cocaine
|
- inhibit reuptake of NE
|
