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19 Cards in this Set
- Front
- Back
Do both adrenergic and cholinergic receptors exist in the brain? |
Yes |
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True or false: Neurons secrete same set of neurotransmitters from all of their synaptic termini
What are some of the neurotransmitters found in the CNS? |
True |
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Where are the highest concentrations of NE found in the brain? |
(LOCAL CERULEUS) Hypothalamus, central nucleus of amygdala, and dentate gyrus of hippocampus |
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What is the local ceruleus involved in regulating? |
Sleep and arousal and associated aspects of attention and vigilance |
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What does stimulation of beta-adrenergic receptors in amygdala enhance? |
Enhances memories for stimuli encoded under strong negative emotion => recall of stimuli predicting danger (PTSD) |
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In the central cholinergic pathways, the effects of Ach are a mixture of both _____ and ____ actions.
What does tho mean? |
Nicotinic and muscarinic
Muscarinic and nicotinic effects can be produced by separate drugs. |
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Identify the cholinergic neurons of the brainstem. What does the brainstem arousal center supply? What is shown by the blue pathways? |
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What neurotransmitter influences motivation, learning, and memory?
Which one influences arousal, attention, vigilance, and memory?
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Ach
NE |
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? |
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DEFINITELY KNOW THE EFFECT ON THE ENDOCRINE SYSTEM!! |
KNOW THE DRUGS THAT ACT ON THE DOPAMINERGIC SYSTEM FOR BOARDS! |
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What do antidepressants block synaptic reuptake of? Where do they act as antagonists? |
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Identify which receptors have been blocked based on the adverse effects.
NE, alpha-1, muscarinic |
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What are the three anticholinergic drugs used in the early stages of Parkinsonism or in conjunction with dopamimetic therapy?
How do these work? |
Loss of dopaminergic neurons in Parkinsons, these neurons normally inhibit the GABAergic output from the striatum, whereas cholinergic neurons produce and EXCITATORY EFFECT (limiting the excitatory effect with anticholinergics). |
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Which two symptoms of PTSD are open to modulation by appropriate anti-adrenergic treatment? |
Intrusion (responds to B) Hyperarousal (responds to alpha) |
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What two drugs are currently indicated for PTSD?
Which two are advocated based upon adrenergic receptor importance in amygdala?
What is the one side effect you should monitor for?
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How do B-blockers vary (in terms of those that would cross the BBB and produce a variety of CNS effects)?
Which generation of H1 antagonists also produce central actions? |
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