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39 Cards in this Set
- Front
- Back
- 3rd side (hint)
blood vessels- vasoconstriction
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alpha 1 receptor sites
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increase peripheral resistance, BP
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alpha 1
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Pupil dilation
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alpha 1
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increase closure of urinary bladder sphincter
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alpha 1
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modulator of norepinephrine release
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alpha 2
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located on beta cells in pancreas, controls insulin release
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alpha 2
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stimulate myocardial activity
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beta 1
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increase heart rate
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beta 1
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increase lypolysis
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beta 1
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located on smooth muscle in blood vessels, cause vasodilation
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beta 2
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dilatin of bronchi
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beta 2
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increased muscle and liver breakdown of glycogen
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beta 2
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increased release of glucagon from pancreas
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beta 2
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relax uterine smooth muscle (during labor)
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beta 2
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pupil constriction
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muscarinic
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Increased GI motility
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muscarinic
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increased secretions (saliva)
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muscarinic
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increase urinary bladder contraction
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muscarinic
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slowing of heart rate
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muscarinic
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causes muscle contraction
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nicotinic
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autonomic responses
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nicotinic receptor sites
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affects release of norepinephrine and epinephrine from adrenal medulla
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nicotinic receptor sites
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affects the heart
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beta 1
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affects the lungs
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beta 2
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location and function of beta 2 receptors
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in smooth muscle of blood vessels- causes vasodilation
bronchi- causes dilation periphery- breakdown of glycogen and release of glucagon uterine muscle- relaxation of muscle |
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location of alpha 1 receptors
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blood vessels- vasoconstriction
iris- dilation urinary bladder-closure of sphincter |
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location and function of alpha 2 receptors
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nerve membranes- act as modulators of norepinephrine release
beta cells of pancreas- help to moderate insulin release |
nerves, pancreas
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location and action of beta 1 receptors
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in cardiac tissue- increases activity and heart rate
in peripheral tissues- increases lipolysis |
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Sympathetic Neurotransmitter terminator
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Monoamine oxidase (MAO), catechol- O-methyltransferase (COMT)
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Parasympathetic Neurotransmitter terminator
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Acetylcholinesterase
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sympathomimetic drugs (andrenergic agonists) usage
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for the treatment of hypotensive states or shock, bronchospasm, and some types of asthma
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Adverse Effects of
sympathomimetic drugs |
arrhythmias,
hypertension, palpitations, angina, dyspnea nausea and vomiting, headache, sweating, and piloerection |
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Phenylephrine ( specific alpha adrenergic agonist)
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Topically it is used to treat allergic rhinitis and to relieve the symptoms of otitis media. Ophthalmically it is used to dilate the pupils for eye examination, before surgery, or to relieve elevated eye pressure associated with glaucoma
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allergic rhinitis, glaucoma, dilate pupils
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Beta-Specific Adrenergic Agonists use
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treat bronchial spasm, asthma, and other obstructive pulmonary conditions
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Clonidine (specific alpha 2 agonist) action
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stimulates directly alpha2-receptors and is used to treat hypertension because its action blocks release of norepinephrine from nerve axons
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Phenylephrine - (alpha 1 specific adrenergic) action
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binds to alpha 1 receptors- used in many cold and allergy remedies because it is a powerful local vasoconstrictor
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adrenergic alpha 1 antagonist (blockers) use
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primarily used to treat cardiac-related conditions, BPH, hypertension
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Isuprel (beta specific adrenergic agonist) use
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shock, cradial standstill,
heart block in transplanted hearts---because increase heart rate,contarctility, conductivity and blood flow prevention of bronchospasm during anesthesia |
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symphatolytic drugs(andrenergic antagonists)
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inhibits the postganglionic functioning of the sympathetic nervous system (SNS), used as antihypertensives
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