Adrenergic Agonists

Front 1

Epinephrine: what receptors stimulates?

Back 1

Все-a1.a2, В1, В2б low doses selective for B1

Front 2

Alpha-1-adrenoreceptor

Back 2

vasoconstriction, increased peripheral resistance,increased BP,mydriasis, closure of the bladder sphincter-альфа никогда не ссыт

Front 3

Alpha-2-adrenoreceptor

Back 3

Inhibition of norepinephrine release
Inhibition of insulin release. Стимуляция альфа-2 рецептора ведет к блоку цАМФ и последующему торможению освобождения norepinephrine.

Front 4

Difference between alpha and beta receptors

Back 4

Alpha receptors show weak response to synthetic agonists, while B-receptors show low response to NE and E

Front 5

Betta-1 receptors action

Back 5

Beta-1 receptors est only on the heart, so they enhance pulse and contactility

Front 6

Function of betta-2 receptors

Back 6

Vasodilation, slight decrease of peripheral resistance, bronchodilation, increased muscle and liver glycogenolysis, increased release of glucagon
-relaxed uterine smooth muscle

Front 7

3 types of adrenergic agonists

Back 7

1.direct acting-stimulate receptor directly
2.indirect acting-enhance release of ТУ from vesicles
3. Mixed acting- direct and indirect acting

Front 8

Another classification of adrenergic agonists

Back 8

-catecholamines
-noncateholamines

Front 9

Naturally occuring catecholamines

Back 9

NE, E, dopamin- all arrive from tyrosine, tyrosine arrives from phenilalanine.

Front 10

Preganglionic fibers of parasympathetic NS are very and postganglionic fibers are very

Back 10

Long preganglionic and short postganglionic

Front 11

Preganglionic fibers of sympathetic fibers form . Preganglionic fibers of sympathetic nerves are

Back 11

Preganglionic fibers form paraspinal ganglia and pre-fibers are short

Front 12

What cathecholamines do you know?

Back 12

Epinephrine, norepinephrine, dopamine

Front 13

Common features of all cathecholamines?

Back 13

Rapid onset of action, brief duration of action, not administered orally,do not penetrate blood-brain barrier

Front 14

Adrenoceptors mnemonic

Back 14

ABCD- alpha constrict, beta dilate

Front 15

Adrenoceptors mnemonic

Back 15

ABCD- alpha constrict, beta dilate

Front 16

Epinephrine: basic receptors?

Back 16

alpha-1 and 2, beta 1 and 2

Front 17

Norepinephrine: basic receptors?

Back 17

alpha 1, alpha 2 nad betta-1 predominate

Front 18

Isoproterenol (изадрин): receptor types?

Back 18

only betta-1 and betta-2 receptors. Селективный бета миметик- БАТЯ ИЗАДРИН

Front 19

Action of norepinephrine on blood pressure?

Back 19

alpha 1 effect- both systolic and diastolic BP rises up because of increased peripheral resistence. Kidney blood glow is also reduced. НОРАадреналин повышает ВСЕ- и ситстолическое и диастолическое

Front 20

Action of epinephrine on blood pressure?

Back 20

betta-1- positive inoropic and chronotropic effect causes increased systolic BP and lows diastolic BP

Front 21

Action of epinephrine on glucose?

Back 21

causes hyperglycemia and lipolysis-стресовая реакция-подем глюкозы, горение жира

Front 22

ISOproterenol (изадрин) action on cardiac function?

Back 22

As in EPInephrine: positive ino-and chronotropic effect and lowering peripheral resistance. Удобно при ав блоке с гипертонией

Front 23

Dopamine effects

Back 23

alpha 1 and beta 1- rises BP, dilates renal blood vessels through D receptors. Positive chrono and inotropic effects like with epinephrine. ХИНА эпинерфрина-положительный хроно и инотропный эффекты

Front 24

Dobutamine action and use

Back 24

Synthetic. Beta-1 activity- only increase of cardiac output and rate, no effects on vessels. Used in chronic cardiac failure

Front 25

Phenylephrine: receptors and action

Back 25

alpha receptors, (в названии 2 части) alpha 1 predominates alpha 2. Vasoconstrictor, rise in systolic and diastolic BP. Used in nasal drops

Front 26

Methoxamine: receptora and action.

Back 26

Alpha 1 over alpha 2 action.Raise in BP. Подъем давления засчет спазмов паренхиматозных органов. METAXA- крепкий конъяк, как нораадреналин

Front 27

Clonidine (клофелин): type, action?

Back 27

alpha-2 agonist т.е. тормозит высвобождение катехоламинов, действуя на пресинаптическую мембрану. Симуляция альфа-2 рецепторов вызывает эякуляцию

Front 28

MAD 2s- группа каких рецепторов?

Back 28

M2,alfa 2, D2- G protein активирует аденилилциклазу-снижается выработка цАМФ- снижается протеинкиназа А