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30 Cards in this Set

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Coupled via Gs to stimulate adenylate cyclase
Beta receptors
Coupled via G to phospholipase C
Alpha 1 receptors
Couple via G to inhibit adenylate cyclase
Alpha 2 receptors
Tyramine
releases cytoplasmic NE in presynaptic terminal via neuronal transport. Indirect acting agonist
Chromaffin cell and indirect acting sympathomimetics
they have no uptake system and are thus unaffect by indirect sympathomimetic amines
Found in certain foods (beer, red wine cheese) and may cause hypertensive crisis in those taking MAOI's.
Tyramine.

MAOI enhance tyramine absoorption in the gut
Mixed-acting drugs (2)
Ephedrine
Amphetamines
Ephedrine in contrast to epenephrine
In contrast to epinephrine, is orally effective, has long duration of action and produces CNS effect. Has effects like tyramine and epinepherine
Has primary effect on heart(β1) and blood vessels (α1) and stimulates CNS. Widely abused. What is it are what are its CNS effects?
Amphetamines cause alertness, euphoria, less fatigue, suppressed appetite
Draw the adrenergic pyramid!
Page 8 of handout
Inhibits adrenergic reabsorption to the presynaptic terminal (2)
Cocaine
Tricycli AD's
Inhibits vesicle formation
Reserpine
Inhibits Tyrosine Hydroxylase
Metyrosine
alpha 1 agonist
Phenylephrine
beta 1 agonist (2)
Dobutamine
Dopamine
beta 2 agonists (3)
Terbutaline
Albuterol
Ritodrine
alpha 2 agonist
Clonidine
beta 1 and 2 agonist
Isoprotenerol
Effects of Phenylephrine
(alpha 1) vasoconstriction, increase peripheral resistance, increased systolic and diastolic BP

Reflex cardiac rate decrease, decreased peripheral blood flow
Effects of Isoproterenol
(beta 1 & 2) increase HR, contraction, automaticity. Vasodilation.

CO increased, increased sys, decreased diastolic, arrythmia, increase periph blood flow
Effect of NE
(a1 b1) increase HR, increase periph resistence, decrease HR, net HR change 0.

Arrythmias, increased BP, blood flow decreased
High dose Epi
alpa 1 predominant, increased BP
Low dose EPi
beta 1, 2. CO up, sys up, dias down, arrythmias
Bronchodilators for asthma attacks
B2's:
Terbutaline
Albuterol
Metaproterenol
Relaxation of uterus to delay pregnancy
B2's:
Ritodrine
Terbutaline
Inhibition of insulin secretion
alpha 2
Clonidine
Good use for failing heart
Dopamine and Dobutamine

Increase rate more than force of contraction
vasodilates kidney withoth changing TPR
Used to treat anaphylactic shock
Epinephrine

Vasopressor actions reduce venous pooling.
Also cardiac inotrophy and inhibition of mast cell degranulation
Cardiogenic shock post MI
Dopamine

Cardiace ionotrophy and redirection of blood to kidney
Wide angle glaucoma
Pheylephrine

vasoconstriction of vessels supplying blood for aqueous humor