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36 Cards in this Set

  • Front
  • Back
3 zones of adrenal cortex and their products
Glomerulosa (mineralocorticoids), fasciculata (glucocorticoid=GC), and reticularis (adrenal androgens)
Pneumonic for 3 zones of adrenal cortex
Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)
Short acting glucocorticoids
Cortisone and hydrocortisone (equivalent to cortisol)
Intermediate acting glucocorticoids
Prednisone, methylprednisolone, prednisolone, and triamcinolone
Long acting glucocorticoids
Betamethasone and dexamethasone
Fludrocortisone and deoxycorticosterone
Some side effects of corticosteroids
Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis, stria, thinning of skin
Period of time of therapy after which GC therapy will need to be tapered
5-7 days
Used for Cushing's syndrome (increased corticosteroid)
Dexamethasone suppression test
Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Antifungal agent used for inhibition of all gonadal and adrenal steroids
Antiprogestin used as potent antagonist of GC receptor
Diuretic used to antagonize aldosterone receptors
Common SE of spironolactone
Gynecomastia and hyperkalemia
Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss
Antiestrogen drugs used for fertility and breast cancer respectively
Clomiphene and tamoxifen
Common SE of tamoxifen and raloxifene
Hot flashes
Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Diethylstilbestrol (DES)
Estrogen mostly used in oral contraceptives (OC)
Ethinyl estradiol and mestranol
Anti-progesterone used as abortifacient
Mifepristone (RU-486)
Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
Combination oral contraceptives (OC)
Oral contraceptive available in a transdermal patch
Converted to more active form DHT by 5 alpha-reductase
5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness
Finasteride (Proscar and Propecia respectively)
Anabolic steroid that has potential for abuse
Nandrolone, oxymetholone, and oxandrolone
Anti-androgen used for hirsutism in females
Cyproterone acetate
Drug is used with testosterone for male fertility
Anti-estrogen used for estrogen receptor + breast cancer
Newer estrogen receptor antagonist used in advanced breast cancer
Toremifene (Fareston)
Increase bone density, also being tested for breast CA prophylaxis
Raloxifene (SERM-selective estrogen receptor modulator)
Aromatase inhibitor used in breast cancer
Letrozole, anastrozole
Anti-androgen used for prostate cancer
Flutamide (Eulexin)
SE seen only in men with administration of ketoconazole
Inhibitors of CYP450
Cimetidine, ketoconazole, erythromycin, isoniazid and grapefruit