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11 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Cosyntropin |
ACTH Analog
Mech: Activates cholestorol esterase
Use: Check integrity of the HPA axis
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Dexamethasone
Betamethasone
Triamcinolone |
Steroid
GC effect without MC effect
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Fludrocortisone |
Cortisol analog
High level of MC activity (can be used for hypoaldoesterone) |
used in Primary adrenal insufficiency (GC defic like addisons)
SE: HTN, cardiac failure |
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Hydrocortisone |
GC=MC activity
used as replacement for adrenal sufficiency
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Prednisone
Prednisolone
Methlyprednisolone |
Other Steriods |
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Metyrapone |
Adrenocorticoid Synthesis Inhibitor
Mech: Inhibitd CYP11B1 (11-deoxycortisol to cortisol)
Use: Tx for hypercortisolism |
SE: can cause hiruitism (shunting to more androgens) |
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Ketoconazole |
Adrenocorticoid Synthesis Inhibitor
Mech: inhibits CYP17 at low doses. Inhbits CYP11A at higher doses
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Drug-drug interaction with other drugs that need the CYP
SE: Gynectomastia and lower libido in males. can increase hepatic transaminiases (reversible)
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Mitotane |
Adrenocorticoid Synthesis Inhibitor
Mech: ?. Blocks 11-hydroxylation |
Long half life that takes week to start of wane |
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Spironolactone |
treats hyperaldosteroneism
Mech: blocks ALD binding to MR |
SE: gynecmastia (bc drug also binds to androgen and progesterone receptors) |
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Eplerenone |
selective towards MR unlike Spirolactone |
SE: monitor K+ levels bc drug is given with ACE inhibitor (this will lead to high K+) |
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Phenoxybenzamine |
Drug for Pheo
Long acting COVALENT Alpha blocker (1 and 2)
Use: control HTN and sweating caused by too much NE and Epi
Mech: blocks vasoconstriction (alpha 1) ->resistance-> refelx tachy (DOES NOT DIALATE just stops constriction). Blocks alpha 2->more NE release->increase CO (Beta 1) |
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