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10 Cards in this Set
- Front
- Back
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Which ADHD drugs are nonstimulants?
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Atomoxetine (Strattera)
Guanfacine XR (Intuniv) Clonidine XR Modafinil Bupropion Tricyclic antidepressants *The rest are stimulants |
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How does metylephenidate work, and how fast does it work?
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It indirectly increases the release of DA and NE from presynaptic terminals with a weaker reuptake
It goes quickly into the CNS because it is lipid soluble. |
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What are adverse side effects with methylphenidate?
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Anorexia, nausea, weight loss, nightmares, insomnia, irritabllity, effect on growth, the rebound phenomenon--when the drug is discontinued suddenly, the symptoms return stronger than they were before treatment first began.
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How does Dexmethylphenidate work?
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It is an enantiomer of methylphenidate. It is twice as potent however and may have less side effects.
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How is ER Ritalin administered?
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By micro-beads in a capsule, which can be opened and sprinkled on food . The effects last 8 hours.
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How is Concerta (methylphenidate) administered?
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By the osmotic pressure delivery system--the capsule cannot be opened. There is a hole that the medicine is pushed through as water expands. Effective for 12 hours. Check for any narrowed GIT problems.
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Which drugs are in the amphetamine group?
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dextroamphetamine, adderall, and lisdexamfetamine (Vyvanse).
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What is unique about Vyvanse?
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It is a prodrug
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What are the reponse rates to ADHD drugs?
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75% with the first stimulant. Nonresponders to one often respond to another in 90% of cases.
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How does Strattera (atomoxatine) work? What is its adverse effect?
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It is a selective inhibitor of NE uptake--inhibiting the presynaptic NE transporter.
It acts in the prefrontal cortex. It has a black box warning for hepatic problems. |
