Ad

Front 1

TCA MOA

Back 1

-block reuptake of 5-HT, NE, DA (mixed 5-HT/NE reuptake inhibitors)
-block cholinergic, histaminergic, and alpha1 adrenergic receptors

Front 2

venlafaxine MOA

Back 2

-potent inhibitor of 5-HT and NE reuptake and a weak inhibitor of DA reuptake (SNRIs)

Front 3

duloxetine MOA

Back 3

-potent inhibitor of 5-HT and NE reuptake and a weak inhibitor of DA reuptake (SNRIs)

Front 4

trazodone, nefazodone MOA

Back 4

-5-HT reuptake inhibitor, 5-HT2 antagonist
-low affinity for alpha1 adrenergic receptors

Front 5

bupropion MOA

Back 5

mixed DA/NE reuptake inhibitor (believed to be a DA reuptake inhibitor w/ possible norarenergic activity

Front 6

mirtazapine

Back 6

-mixed serotonin/NE effects
-enhances central noradrenergic and serotonin acitivity through antagonism of central presynaptic alpha2 adrenergic autoreceptors and heteroreceptors
-anticholinergic, antihistaminergic (low doses)

Front 7

phenelzine, tranylcypromine MOA

Back 7

-non-selective MAO inhibitors
-inhibit MAO enzyme increasing concentrations of NE, DA, 5-HT within neuronal synapse

Front 8

selegiline MOA

Back 8

MAO-I, type B selective

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St. Johns Wort MOA

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believed to inhibit reuptake of serotonin

Front 10

TCA adverse effects (7)

Back 10

1)cardiac conduction delays
2)seizures
3)sexual dysfunction
4)excessive perspiration
5)weight gain
6)drowsiness, weakness, lethargy, fatigue
7)anticholinergic, antihistaminergic, alpha1 adrenergic blockade

Front 11

venlafaxine adverse effects (7)

Back 11

1)dose related increase in BP at higher doses
2)sexual dysfunction
3)insomnia
4)dry mouth
5)agitiation
6)sweating
7)dizziness, HA, nausea, contipation

Front 12

duloxetine adverse effects (6)

Back 12

1)may increase LFTs
2)nausea, diarrhea, constipation
3)insomnia
4)fatigue
5)dry mouth
6)dizziness

Front 13

SSRIs adverse effects (4)

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1)sleep disturbances
2)sexual dysfunction
3)anxiety, tremor
4)nausea, HA

Front 14

SSRI associated with the most diarrhea

Back 14

sertraline

Front 15

SSRI associated with the most agitation

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fluoxetine

Front 16

SSRI associated with the most sedation and weight gain

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paroxetine

Front 17

trazodone, nefazodone adverse effects

Back 17

1)sedation
2)orthostatic hypotension
3)priapism
4)hepatotoxicity (nefazodone black box)

Front 18

bupropion adverse effects

Back 18

1)dry mouth
2)insomnia
3)HA, NV, constipation
4)agitiation, anxiety, tremor, dizziness

Front 19

buproprion is contraindicated in what patients?

Back 19

those patients having seizures

Front 20

mirtazapine adverse effects

Back 20

1)sedation
2)weight gain, increased appetite
3)constipation
4)dry mouth

Front 21

List antidepressants associated with the following characteristics: activating

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1)SNRIs
2)SSRIs (except paroxetine, fluvoxamine)
3)bupropion
4)high-dose mirtazapine

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Sedating

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1)TCA
2)trazodone, nefazodone
3)low-dose mirtazapine

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Sexual dysfunction

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1)TCAs
2)SNRIs
3)SSRIs

Front 24

Weight gain

Back 24

1)TCAs
2)paxil
3)mirtazapine

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Seizures

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1)bupropion
2)TCAs

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Hepatotoxic

Back 26

1)nefazodone
2)fluvoxamine