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26 Cards in this Set

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TCA MOA
-block reuptake of 5-HT, NE, DA (mixed 5-HT/NE reuptake inhibitors)
-block cholinergic, histaminergic, and alpha1 adrenergic receptors
venlafaxine MOA
-potent inhibitor of 5-HT and NE reuptake and a weak inhibitor of DA reuptake (SNRIs)
duloxetine MOA
-potent inhibitor of 5-HT and NE reuptake and a weak inhibitor of DA reuptake (SNRIs)
trazodone, nefazodone MOA
-5-HT reuptake inhibitor, 5-HT2 antagonist
-low affinity for alpha1 adrenergic receptors
bupropion MOA
mixed DA/NE reuptake inhibitor (believed to be a DA reuptake inhibitor w/ possible norarenergic activity
mirtazapine
-mixed serotonin/NE effects
-enhances central noradrenergic and serotonin acitivity through antagonism of central presynaptic alpha2 adrenergic autoreceptors and heteroreceptors
-anticholinergic, antihistaminergic (low doses)
phenelzine, tranylcypromine MOA
-non-selective MAO inhibitors
-inhibit MAO enzyme increasing concentrations of NE, DA, 5-HT within neuronal synapse
selegiline MOA
MAO-I, type B selective
St. Johns Wort MOA
believed to inhibit reuptake of serotonin
TCA adverse effects (7)
1)cardiac conduction delays
2)seizures
3)sexual dysfunction
4)excessive perspiration
5)weight gain
6)drowsiness, weakness, lethargy, fatigue
7)anticholinergic, antihistaminergic, alpha1 adrenergic blockade
venlafaxine adverse effects (7)
1)dose related increase in BP at higher doses
2)sexual dysfunction
3)insomnia
4)dry mouth
5)agitiation
6)sweating
7)dizziness, HA, nausea, contipation
duloxetine adverse effects (6)
1)may increase LFTs
2)nausea, diarrhea, constipation
3)insomnia
4)fatigue
5)dry mouth
6)dizziness
SSRIs adverse effects (4)
1)sleep disturbances
2)sexual dysfunction
3)anxiety, tremor
4)nausea, HA
SSRI associated with the most diarrhea
sertraline
SSRI associated with the most agitation
fluoxetine
SSRI associated with the most sedation and weight gain
paroxetine
trazodone, nefazodone adverse effects
1)sedation
2)orthostatic hypotension
3)priapism
4)hepatotoxicity (nefazodone black box)
bupropion adverse effects
1)dry mouth
2)insomnia
3)HA, NV, constipation
4)agitiation, anxiety, tremor, dizziness
buproprion is contraindicated in what patients?
those patients having seizures
mirtazapine adverse effects
1)sedation
2)weight gain, increased appetite
3)constipation
4)dry mouth
List antidepressants associated with the following characteristics: activating
1)SNRIs
2)SSRIs (except paroxetine, fluvoxamine)
3)bupropion
4)high-dose mirtazapine
Sedating
1)TCA
2)trazodone, nefazodone
3)low-dose mirtazapine
Sexual dysfunction
1)TCAs
2)SNRIs
3)SSRIs
Weight gain
1)TCAs
2)paxil
3)mirtazapine
Seizures
1)bupropion
2)TCAs
Hepatotoxic
1)nefazodone
2)fluvoxamine