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25 Cards in this Set

  • Front
  • Back
Is AML lymphoid?
no. duh
Cells lines that could be AML
Granulocytes, monocytes, erythrocytes, megaloblasts, or combo
What percent of acute leukemias are AML?
70%
Etiology of AML
98-99% Idiopathic
AML morphology
-20% more blasts in PB or BM
PB in AML looks like?
-thrombocytopenia +/- anemia
-WBC variable (high d/t blasts or no blasts in pb, depends)
BM in AML looks like?
Hypercellular and monomorphic population of blasts
Clinical presentation of patients with AML
-Symptoms of BM failure
-easy bleeding/bruising
-thrombocytopenia
-fatigue and pallor from anemia
-fever and infections from neutropenia
is AML aggresive?
VERY AGGRESSIVE

remission w/ chemo, but only 25% 5 yr survival
Things that make AML prognosis worse
-secondary to MDS or previous chemotherapy

-Advanced age, extremely high WBC count
Cytogenics of AML
Usually CD34 positive

Myeloid markers-CD13, CD33, MYELOPEROXIDASE
Cytogenics of ALL
usually CD 34 positive

Lymphoid markers-CD10+, T&B cell markers, TdT
Auer rods
Myeloperoxidase crystals
What do Auer rods mean?
These mean AML (or some granulocytic differentiation)
What does NO auer rods mean?
it could be AML or ALL... Can't differentiate without cytogenetics
M0
-Minimally differentiated AML
-Myeloid antigens-CD13+, CD33+
M1
AML without differentiation

myeloperoxidase positive, CD33+,CD13+, Could have auer rods
M2
AML with maturation

-Most common type of AML
-Full range of granulocyte precursors, but blast >20%
-CD13+, Myeloperoxidase positive, usually with Auer rods
M3
Acute Promyelocytic Leukemia

-Most BM cells are hypergranular promyelocytes and myeloblasts
-Many Auer rods
-Younger patients (35-40)
-Often have DIC
-t(15:17)
M4
Acute Myelomonocytic Leukemia
-Myeloblasts plus monocytes
-Myelo-CD13+, Myeloperoxidase+, auer rods, maybe
MONO-CD14+, CD64+, Non-specific esterase+, myeloperoxidase-
M5
Acute Monoblastic Anemia

-elderly patients, more tissue infiltration than other aml
-CD14+, CD64+, non-specific esterase, myeloperoxidase-, auer rod-

M5a-les mature M5b-more mature
M6
Acute erythroleukemia

-Myeloblasts>20%, but dysplastic erythroid precursors more than half of BM cells, often with ring shaped perinuclear vacuoles

usually profound anemia, but numerous precursors in PB (dysplastic)
M7
Acute Megakaryocytic Leukemia

Blasts of megakaryocytic lineage, CD41a+, Platelet-specific AB against GPIIb/GIIIa or VWF

-inc BM fibrosis
-Inc incidince with Down Syndrome
M3 cytogenicis
t(15:17) -- with this, long-term prognosis is favorable
AML M4 EOS
AML subtype with abnormal eosinophil precursors

-inv 16
-favorable prognosis