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20 Cards in this Set
- Front
- Back
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why do you see gum infiltration in acute monocytic leukemia
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moncytic origin means they still retain the ability to reside in tissue (like a monocyte would enter tissue to become a macrophage)
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what defines acute vs chronic leukemia
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acute leukemia indicates >20% blasts - see cells halted at blast stage
chronic has <10% blasts and you see varying WBCs at different stages |
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FAB grouping of AML
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M0 - AML minimal differentiation
M1 - AML with differentiation (sheets of blasts) M2 - AML with maturation (blasts+maturing myelocyte) M3 - APL - promyelocytic M4 - AMMoL - meyelomonocytic M5 - AMoL - monocytiv M6 - AEleuk - erythroleukemia - myeloblasts+erythroid precursor M7 - AMkL - acute megakaryocytic leukemia |
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t(8,21)(q22;q22)
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M2 associated translocation
often has panBcell marker CD19 |
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inv(16)(p13;q22)
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M4 with eosinophilia
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t(15;17)(q22;q12)
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M3 - acute promyelocytic leukemia
translocation involves retinoic receptor can treat this cancer with vitamin A |
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prognosis of radiation induced AML
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BAD
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sudan black B stain
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myeloblast lineage only
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choloroacetate esterase stain
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myeloblast lineage only
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TdT stain
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lymphoBLASTs only
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auer rods
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ONLY AML, but never ins M0 or M7
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myeloperoxidase stain
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stains myeloid lineage only
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M7 - acute megakaryocytic leukemia
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blasts are MPO/SBB negative
CD41a (gpIIb/IIIa) or CD61(gpIIIa) positive look for blebbing |
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HLA-DR-, CD34-
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M3
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Which AML types do you NEED flow cytometry for
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M0, M7
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Uses of Flow Cytometry in AML
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define lineage
M0,M7 disease associated phenotype: M3, t(8,21) following treatment effectiveness |
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acute lymphoid leukemia FAB classification
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L1 - looks like normal lymphocyte except bigger
L2 - looks like myeloidblast L3 - burkitt's, large cells with large round nuclei, several nucleolus, basophilic cytoplasm with vacuoles stains with oil red O. |
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B cell acute lymphocytic leukemia is also known as
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Burkitt's lymphoma
TdT- |
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Hypodiploid in ALL is good or bad prognosis
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bad
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Hyperdiploid in ALL is good or bad prognosis
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good
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