Activation Of Fatty Acids

Front 1

acyl CoA synthetase

Back 1

converts a fatty acid and HS CoA to acyl-CoA

Front 2

fatty acid + HS CoA --> acyl-CoA
2 Steps of the Reaction:

Back 2

1.) the fatty acid forms acyl adenylate with AMP
2.) then the AMP is exchanged for a thioester with CoA

--ATP --> AMP and PPi