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8 Cards in this Set
- Front
- Back
- 3rd side (hint)
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ISIS-2 Trial |
Aspirin in AMI
5wk vascular mortality reduction: ASA alone 20% Streptokinase 23% Both 40% |
Lancet 1988
Won't ever be repeated One of the first thrombolytic trials |
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TIMI II-B Trial |
No difference in mortality with early vs late BB for AMI.
*all pts got tPA *early IV then PO vs late PO (5 days) *also no decrease of infarct size |
Circ 1991
Use of b blockers in AMI |
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COMMIT Trial |
Supported TIMI II-B results (no difference in early vs late BB in AMI).
Addition to literature: *More bradycardia, hypotension, shock with BB (not seen in TIMI-2 because they were more careful about who got BBs) => no absolute indication for BB in AMI |
Lancet 2005
Similar to TIMI II-B but added another point about BB use |
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Effect of BB on mortality in acute MI? |
In AMI without HF/LVSD, BB not associated with a lower risk of death at any time point up to 1 year.
(Dondo et al JACC 2017) |
Compares AMI pts with CHF/LV systolic dysfunction vs those without |
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TRACE Trial NEJM 1995 |
In pts with reduced LVEF after AMI, long-term ACE (trandolapril) significantly reduced the risk of overall mortality, mortality from cardiovascular causes, sudden death, and the development of severe HF.
*EF<35%, ACE or placebo started between post-MI day 3 and 7 |
Use of ACE inhibitors in AMI |
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GISSI-3 Trial Lancet 2005 |
Lisinopril reduces 6wk mortality by 11% when administered within 24h of AMI. |
ACE in AMI |
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CURE Trial NEJM 2001 |
In UA/NSTEMI, DAPT with clopidogrel and ASA reduced CV mortality, non-fatal MI, or CVA but increased rate of major bleeding. |
DAPT |
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TEMPLATE TRIAL JOURNAL YEAR |
Trial results |
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